Association between refractory hypertension and obstructive sleep apnea

Abstract

OSA and reduced REM sleep time are associated with increased odds of having RHT and, therefore, may play roles in its pathogenesis.

Effects of Renal Sympathetic Denervation on Blood Pressure, Sleep Apnea Course, and Glycemic Control in Patients With Resistant Hypertension and Sleep Apnea

“…OSA may occur in Ͼ80% of patients with resistant hypertension. 2,4,19 For the first time, we report on patients with both resistant hypertension and OSA (8 with OSA syndrome and in 2 with mixed obstructive and central sleep apnea). In all of the patients the catheter-based therapy caused substantial and significant reductions in systolic and diastolic BPs.…”

Truly Refractory Hypertension

“…Ruttanaumpawan et al found that about half of their 42 therapy-resistant patients with hypertension were suffering from obstructive sleep apnea. 4 Of course, there is always the lingering possibility that the patients are just not ingesting their medicines, and novel strategies have been developed to deal with that issue. 5 The advent of devicerelated treatments has pretty well laid the issue of refractory hypertension to rest.…”

Resistant hypertension: epidemiology and risk factors

“…Faccenda (68 пациентов), Dimsdale (39 пациентов), Barbe (55 пациентов), Pepperell (95 паци-ентов), Monasterio (125 пациентов), подтверждают связь между СОАС и развитием АГ. Доказано, что уже через неделю лечения СОАС методом постоянного положи-тельного давления в дыхательных путях (Constant Positive Airway Pressure, CPAP) наблюдается снижение как систолического, так и диастолического АД [36]. При-менение СИПАП-терапии у пациентов с СОАС значи-тельно снижает риск впервые возникшей АГ [37], в то время как за 12 лет наблюдения за пациентами с нор-мальным уровнем АД и СОАС существенно увеличивался риск развития АГ [38].…”