Association between red blood cell distribution width (RDW) and carotid artery atherosclerosis (CAS) in patients with primary ischemic stroke

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

“…Furthermore, it has been shown that there is a positive correlation between both hs‐CRP and RDW with carotid intimal‐medial thickness in patients suffering from primary ischemic stroke. This study also suggested RDW may be a predictor of the presence carotid artery atherosclerosis . Vayá et al evaluated the correlation between RDW and stroke in 163 patients hospitalized due to cryptogenic stroke and 186 healthy subjects who were adjusted according to age, sex, anemia, lipid profile, and other potential confounders.…”

The decisive role of red cell distribution width in carotid endarterectomy patients

“…[3][4][5][6] Studies associated with stroke and RDW usually demonstrate the results related with the severity of stroke, outcome and the course of disease, [14][15][16][17] the relationship between the RDW, CCA-IMT, and CP has been mostly investigated in carotid artery disease studies. [5,8] However, CCA and IMT are subclinical atherosclerotic markers; [9,10] and it seems it would be beneficial, if the relationship between the RDW and atherosclerotic CAS, which increases stroke, is investigated in patients undergoing CEA. The presence of ≥50% stenosis is critical in most of the strokes associated with carotid artery disease that is why we also investigated the possible relationship between the RDW and stenosis.…”

“…[2][3][4][5][6][7][8] A prospective study conducted by the National Health and Nutrition Examination Surveys (NHANES) reported that RDW is an independent atherosclerotic risk factor, apart from the conventional risk factors and nutritional deficiencies in patients who did not have CVD. [2] Comprehensive prospective and randomized studies on CHD, MI, HF, and stroke showed that RDW was a strong predictor of the mortality in the middle or older ages.…”

“…[1] There are numerous comprehensive studies denoting the importance of increased RDW values being the deterministic factor for death in healthy and high-risk individuals in terms of myocardial infarction (MI) and heart failure (HF), as well as in the development, severity, and outcome of stroke, and even for all-cause mortality. [2][3][4][5][6][7][8] In the developing cardiac pathologies, the relationship between the coronary heart diseases (CHD) and RDW values have been put forward, while the relation with the intima-media thickness of the common carotid arteries (CCA-IMT), carotid plaques (CPs), and RDW values have been established for carotid arterial diseases. [5,[8][9][10] Therefore, these variables are effective in predicting stroke independently from the carotid arterial stenosis (CAS).…”

“…[2][3][4][5][6][7][8] In the developing cardiac pathologies, the relationship between the coronary heart diseases (CHD) and RDW values have been put forward, while the relation with the intima-media thickness of the common carotid arteries (CCA-IMT), carotid plaques (CPs), and RDW values have been established for carotid arterial diseases. [5,[8][9][10] Therefore, these variables are effective in predicting stroke independently from the carotid arterial stenosis (CAS). [11,12] The majority of the strokes due to atherosclerotic CAS usually occur in the presence of ≥50%.…”