Association between Red Blood Cell Distribution Width and Acute Pancreatitis

Karabulut, Keziban Uçar; Narcı, Hüseyin; Uçar, Yıldız; Uyar, Mehmet

doi:10.12659/msm.891075

Cited by 13 publications

(11 citation statements)

References 16 publications

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“…The rise of RDW reflects variable volume enlargement of red blood cells, which was associated with a number of diseases including coronary artery disease, stroke, renal insufficiency, and severe infection [ 10 – 12 ]. The increasing number of studies has shown that increased RDW is associated with mortality in AP [ 13 – 16 ]. It is surprising to find RDW as a prognostic factor of AP mortality for many researchers who thought that we have known plenty of the complete blood count and specifically RDW.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Early Prognostic Factors of Mortality in Patients with Acute Pancreatitis: A Retrospective Study

Zhang

Yao

et al. 2017

Gastroenterology Research and Practice

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Early and accurate assessment of severity in acute pancreatitis (AP) is of great importance to provide effective disease management and prevent mortality. In this study, we aim to evaluate early indicators that predict the mortality of AP. We retrospectively analyzed 24-hour clinical characteristics and laboratory data in 166 AP patients recruited between January 2014 and November 2015 in Baotou Central Hospital. In total, 18 patients did not survive the disease. Multivariate logistic regression showed that red cell distribution (RDW) (OR = 2.965, P = 0.001) and creatinine (OR = 1.025, P = 0.005) were early independent risk factors of AP mortality while albumin (OR = 0.920, P = 0.032) levels reduced AP mortality. The corresponding optimal cut-off values were 14.45, 125.5, and 34.95, respectively. The positive predictive values of the AP mortality were 80.1%, 54.5%, and 69.5%. In combined measurement, the area under the curve of RDW, creatinine, and albumin was 0.964 (95% CI: 0.924 to 1.000, P < 0.001). RDW ≥ 14.45%, creatinine ≥ 125.5 μmol/l, and albumin ≤ 34.95 g/l indicated a good predictive value for mortality in AP patients with a sensitivity of 100% and specificity of 64.2%. RDW, creatinine, and albumin may serve as early indicators for AP mortality which warrants further clinical investigation.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Early Prognostic Factors of Mortality in Patients with Acute Pancreatitis: A Retrospective Study

Zhang

Yao

et al. 2017

Gastroenterology Research and Practice

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Section: Rdw and Pancreatic Disordersmentioning

confidence: 99%

“…Uçar Karabulut et al[ 59 ] studied 104 patients with AP and found that the mean admission RDW value was significantly higher during the acute phase compared to after recovery ( P < 0.01). Although patients with severe pancreatitis were excluded and the severity of disease was not analyzed in this study, an increased RDW was identified as a reliable marker of AP, so suggesting that this parameter can be used for early detection and prognostic evaluation[ 59 ]. Cetinkaya et al[ 60 ] performed both univariate and multivariate analyses in a retrospective cohort study of 102 patients, identifying both RDW and RPR on admission were independent and significant factors for predicting the risk of in-hospital mortality in APs ( P = 0.001).…”

Section: Rdw and Pancreatic Disordersmentioning

confidence: 99%

Prognostic significance of red blood cell distribution width in gastrointestinal disorders

Goyal

Lippi

Gjymishka

et al. 2017

WJG

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The red blood cell distribution width (RDW) is a routinely measured and automatically reported blood parameter, which reflects the degree of anisocytosis. Recently, the baseline RDW was found to have clinical significance for assessing clinical outcome and severity of various pathological conditions including cardiovascular diseases, sepsis, cancers, leukemia, renal dysfunction and respiratory diseases. A myriad of factors, most of which ill-defined, have an impact on the red cell population dynamics (i.e., production, maturation and turnover). A delay in the red blood cell clearance in pathological conditions represents one of the leading determinants of increased anisocytosis. Further study of RDW may reveal new insight into inflammation mechanisms. In this review, we specifically discuss the current literature about the association of RDW in various disease conditions involving the gastrointestinal and hepatobiliary systems. We also present some of the related measurements for their value in predicting clinical outcomes in such conditions. According to our data, RDW was found to be a valuable prognostic index in gastrointestinal disorders along with additional inflammatory biomarkers (i.e., C reactive protein, erythrocyte sedimentation rate, and platelet count) and current disease severity indices used in clinical practice.

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“…Given the abundance of data supporting the association between an increased RDW and AP in human medicine, 2,7,11,26–35 as well as a recent, large veterinary study showing an association with increased RDW and all‐cause mortality, 40 the lack of significance of RDW in the current study was unexpected. No significant associations were noted between RDW and the endpoints measured.…”

Section: Discussionmentioning

confidence: 72%

“…Acute pancreatitis (AP) is a complex, potentially fatal disease process resulting from intrapancreatic activation of digestive enzymes that culminates in varying degrees of neutrophilic inflammation, edema, and pancreatic necrosis 1–3 . Common clinical signs of AP include abdominal discomfort, vomiting, lethargy, anorexia, and collapse 4 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of red blood cell distribution width, neutrophil‐to‐lymphocyte ratio, and other hematologic parameters in canine acute pancreatitis

Johnson

Gicking²,

Keys³

2023

J Vet Emergen Crit Care

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ObjectiveTo determine if RBC distribution width (RDW), neutrophil‐to‐lymphocyte ratio (NLR), and other hematological parameters are associated with increased odds of in‐hospital mortality, increased length of hospitalization (LOH), or disease severity as measured by the Canine Acute Pancreatitis Severity (CAPS) score in dogs with acute pancreatitis (AP).DesignRetrospective, multicenter study from January 2016 to August 2020.SettingFour private emergency and specialty referral centers.AnimalsOn initial case search, 118 client‐owned dogs were identified with a clinical diagnosis of AP. Out of these cases, 114 dogs met inclusion criteria, defined as sudden onset of ≥2 compatible clinic signs (lethargy, anorexia, vomiting, or abdominal pain), a specific canine pancreatic lipase concentration >400 μg/L, hospital admission, as well as CBC and serum biochemistry run within 48 hours of initial hospitalization. Disease severity was calculated and measured using the CAPS score, in addition to LOH and in‐hospital mortality.InterventionsNone.Measurements and Main ResultsClinical endpoints were in‐hospital mortality, LOH, and disease severity, as evaluated by the CAPS score. Overall in‐hospital mortality was 36.8%. NLR was significantly associated with survival, with a higher percentage being associated with an increased likelihood of nonsurvival (odds ratio: 1.1, 95% confidence interval: 1.0–1.2; P = 0.006, adjusted P = 0.04). Increased NLR was found to be significantly associated with a longer LOH based on the unadjusted P‐value (P = 0.02) but was not statistically significant based on a P‐value adjusted for multiple comparisons (P = 0.12). No significant associations were noted when RDW, platelet‐to‐lymphocyte ratio, WBC count, mean platelet volume, RDW‐to‐platelet ratio, or RDW‐to‐total serum calcium ratio was evaluated against outcome measures.ConclusionsThis study retrospectively evaluated the prognostic utility of several readily available hematological parameters in dogs hospitalized for AP. Dogs with an increased NLR may have a higher risk of in‐hospital mortality and increased LOH, although future prospective studies are necessary to confirm these findings.

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Association between Red Blood Cell Distribution Width and Acute Pancreatitis

Cited by 13 publications

References 16 publications

Evaluation of Early Prognostic Factors of Mortality in Patients with Acute Pancreatitis: A Retrospective Study

Evaluation of Early Prognostic Factors of Mortality in Patients with Acute Pancreatitis: A Retrospective Study

Prognostic significance of red blood cell distribution width in gastrointestinal disorders

Evaluation of red blood cell distribution width, neutrophil‐to‐lymphocyte ratio, and other hematologic parameters in canine acute pancreatitis

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