Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Abstract

Stent thrombosis is a rare but potentially fatal complication of percutaneous coronary interventions (PCIs). In recent years, the predictive and prognostic value of the red cell distribution width (RDW) as an indicator of inflammation has been shown in many cardiovascular diseases. Aim of this study was to examine the predictive value of RDW for stent thrombosis in patients who underwent successful stent implantation for ST-elevation myocardial infarction (STEMI).In this retrospective study, 146 patients who underwent successful PCI to native coronary artery due to STEMI previously and presented with acute coronary syndrome with stent thrombosis were included (stent thrombosis group). A total of 175 patients who had similar procedural characteristics (type, diameter, and length of stent) and not had stent thrombosis were consisted control group.Patients were divided into tertiles according to the admission RDW values (12.9 ± 0.4, 14.2 ± 0.4, and 16.3 ± 1.5, respectively). Stent thrombosis developed in 47 (40.9%) patients in the lowest tertile, 39 (37.9%) patients in mid tertile, and 60 (58.3%) patients in the highest tertile (P = 0.006). Female gender ratio was statistically significantly higher in the 3rd tertile (13 [11.3%], 8 [7.8%], 24 [23.3%], P = 0.003, respectively). RDW (OR: 1.397 [95% CI 1.177–1.657], P < 0.001) and platelet count (OR: 1.008 [95% CI 1.004–1.012], P < 0.001) remained independent predictors of stent thrombosis after multivariate logistic regression analysis. ROC curve analysis demonstrated that, admission RDW values higher than 13.9 can predict the development of stent thrombosis with a sensitivity of 57% and a specificity of 52% (The area under the ROC curve: 0.59 [95% CI 0.53–0.65] P = 0.007).High RDW values found to be independently associated with the development of stent thrombosis in patients with STEMI.

Role of RDW in Prediction of Burn after Caustic Substance Ingestion

“…It’s calculated by dividing the MPV by the standard deviation of erythrocytes and then multiplied for 100, to show the data as a percentage. Although it has long been used for differential diagnosis of anemias, it has emerged as a new risk marker for many different diseases associated with acute and chronic inflammation [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”

“…There are studies in the literature demonstrating the relation between inflammation and markers in complete blood count (CBC); such as red blood cell distribution width (RDW), mean corpuscular volume (MPV), platelet distribution width (PDW), lymphocyte and neutrophil counts. Red cell distribution width, a quantitative measurement of variability and size of the erythrocytes, has emerged as either a diagnostic or a prognostic factor in many diseases such as coronary artery disease, epithelian ovarian cancer and acute pancreatitis [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Herein, we presented a study that demonstrates RDW as a novel diagnostic marker in the diagnosis of burns in CSI before EGD.…”

Effects of VDBP and VDR Mutations and Other Factors to the Development of Stent Thrombosis in Coronary Artery Disease Patients

“…Yapılan çalışmalar D vitamini tedavisinin endotelyal fonksiyonda, özellikle plak oluşumu ve progresyonu yoluyla kardiyovasküler hastalıklarda kritik rolü olduğu düşünülmektedir (12). 25 (16). Şimdiye kadar VDR geni üzerinde birçok mutasyon tanımlanmakla birlikte genin ikinci ekzon bölgesinde gözlemlenen rs2228570 mutasyonuna sık olarak rastlanmaktadır.…”

“…Hb1Ac ile rs1544410 mutasyonu arasındaki ilişki ise Tablo 5'te özetlenmiştir.TARTIŞMAKAH'ı olan bireylerde stent implantasyonu hastalığın tedavisinde kullanılan en yaygın ve etkili yöntemler arasında yer almaktadır. Hastalara stent takılmasını takip eden belli dönem aralığında hastalarda nadir ancak oldukça tehlikeli kabul edilen ST oluşum riski bulunmaktadır(25). ST'yi tetikleyen en önemli faktör, ilgili stentin yerleştirildiği…”

Incidência de Trombose de Stent Após Intervenção Coronária Percutânea no Infarto Agudo do Miocárdio / Incidence of Stent Thrombosis after Percutaneous Coronary Intervention in Acute Myocardial Infarction

“…Entretanto, essa terapia pode cursar com novos problemas, como oclusão de ramos laterais, trombose de stent e reestenose. (TUNÇEZ A, et al, 2017).…”