Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study

Ninomiya, Toshiharu; Nagata, Michio; Hata, Jun; Hirakawa, Yoichiro; Ozawa, Mio; Yoshida, Daigo; Ohara, Tomoyuki; Kishimoto, Hiro; Mukai, Naoko; Fukuhara, Mikio; Kitazono, Takanari; Kiyohara, Yutaka

doi:10.1016/j.atherosclerosis.2013.09.023

Cited by 106 publications

(98 citation statements)

References 43 publications

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“…5,9,[19][20][21] In our study, however, they were not significantly different between the 3 groups, which may be attributed to the distribution of the serum AA level as shown in Figure 3C. We speculate that the dietary habits of the patients affect the distribution of the serum AA level.…”

Section: Discussioncontrasting

confidence: 47%

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Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

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SummaryA relationship between serum polyunsaturated fatty acids (PUFAs) and cardiovascular disease has been reported; however, the existence of a relationship between serum PUFAs and extent of vessel disease (VD) in patients with ST elevation myocardial infarction (STEMI) remains unclear.Between July 2011 and June 2015, 866 consecutive STEMI patients underwent emergent percutaneous coronary intervention, 507 of whom were enrolled and classified into three groups according to the initial angiograms: 1VD, 294 patients; 2VD, 110 patients; and 3VD/left main trunk disease (LMTD), 103 patients. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, and other laboratory data during hospitalization were evaluated.The serum EPA level in the 3VD/LMTD group was significantly lower than that in the 1VD group (55.5 ± 22.1 versus 66.2 ± 28.7, P = 0.002) and was slightly lower than that in the 2VD group (55.5 ± 22.1 versus 65.2 ± 28.9, P = 0.0167). Multivariate adjustment analysis revealed that age !70 years (odds ratio, 1.72; 95% confidence interval, 1.03-2.89; P = 0.038) and a low serum EPA level (odds ratio, 0.98; 95% confidence interval, 0.99-1.00; P = 0.023) were independent risk factors for 3VD/LMTD, while a low serum DHA level was not.A low serum EPA level may be more strongly related than a low serum DHA level to the extent of VD in STEMI patients. Age !70 years and a low serum EPA level may be independent risk factors for 3VD/LMTD.(Int Heart J 2017; 58: 868-873) Key words: Eicosapentaenoic acid, Docosahexaenoic acid, Mulivessel disease, Acute coronary syndrome, Cardiovascular disease A n association between fish intake and risk of cardiovascular disease has been demonstrated in several epidemiological studies and clinical trials.

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Section: Discussioncontrasting

confidence: 47%

“…[1][2][3][4] Fish oil includes n-3 polyunsaturated fatty acids (PUFAs), among which eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are known to be inversely associated with the extent of atherosclerosis, cardiovascular events, and mortality. [5][6][7][8][9][10][11][12] …”

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confidence: 99%

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

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“…No side effects were observed, and there was no significant difference in the incidence of adverse events between groups. In addition, no significant changes in the ratio of EPA and ARA EPA/ARA in plasma were observed in both groups in per-protocol population Table 4 and ITT population data not shown , although blood EPA/ ARA was reported to correlate with the risk for cardiovascular disease 45,46 . Thus, LCPUFA supplementation in the present study is considered safe under the conditions described here.…”

Section: Discussionmentioning

confidence: 94%

Low Doses of Long-chain Polyunsaturated Fatty Acids Affect Cognitive Function in Elderly Japanese Men: A Randomized Controlled Trial

et al. 2015

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“…Mishina et al showed that, in patients with ischemic stroke, the modified Rankin Scale, one of the assessment tests for clinical severity, was negatively correlated with the EPA/AA ratio and positively correlated with the DHA/AA ratio 27) . In addition, the Hisayama Study suggested that a lower EPA/AA level is associated with a greater risk of death from cardiovascular causes in the general Japanese population 56) . On the other hand, a population-based cross-sectional study reported that DHA, but not EPA, has an inverse association with the carotid IMT 20) .…”

Section: Discussionmentioning

confidence: 99%

An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia

Itô

Satoh‐Asahara

Yamakage

et al. 2014

JAT

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Aim: Previous epidemiological studies demonstrated that the ratio of n-6 to n-3 polyunsaturated fatty acids is associated with cardiovascular diseases. We herein investigated whether the beneficial effect of highly purified eicosapentaenoic acid (EPA) on arterial stiffness is associated with changes in the ratio of polyunsaturated fatty acids, such as EPA, docosahexaenoic acid (DHA) and dihomo-γ-linolenic acid (DGLA), relative to arachidonic acid (AA), in obese Japanese patients with dyslipidemia. Methods: The EPA/AA, DHA/AA and DGLA/AA ratios were compared between obese patients with (n=94) and without (n= 31) dyslipidemia. Among the former group, 88 patients received either highly purified EPA treatment (1.8 g daily, n = 45) or treatment without EPA (control, n = 43). Results: At baseline, the ratios of DHA/AA and DGLA/AA were significantly (P＜0.05) higher in obese patients with dyslipidemia than in those without, while the EPA/AA ratio was similar between patients with and without dyslipidemia. EPA significantly reduced the hemoglobin A1c, total cholesterol, triglycerides, CRP, cardio-ankle vascular index (CAVI) (an index of arterial stiffness) and the DGLA/AA ratio relative to the control at three months after the treatment. On the other hand, EPA significantly increased the adiponectin level and EPA/AA ratio (P＜0.05). A multivariate regression analysis revealed that only age, an increase in the EPA/AA ratio and a decrease in the CRP level were significant determinants of a reduction of the CAVI by EPA. Conclusion: These findings suggest that EPA improves the arterial stiffness in association with an increase in the EPA/AA ratio and a decrease in inflammation in obese patients with dyslipidemia. J Atheroscler Thromb, 2014; 21:248-260.

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Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study

Cited by 106 publications

References 43 publications

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

Low Doses of Long-chain Polyunsaturated Fatty Acids Affect Cognitive Function in Elderly Japanese Men: A Randomized Controlled Trial

An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia

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