Association between R.E.N.A.L nephrometry score and perioperative outcomes following open partial nephrectomy under cold ischemia

Park, Dong Soo; Hwang, Jin Ho; Kang, Moon Hyung; Oh, Jong Jin

doi:10.5489/cuaj.1372

Cited by 8 publications

(9 citation statements)

References 31 publications

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“…A full‐text review of the last 127 articles excluded those articles that could not obtain data and did not conform to the type of research. A total of 20 studies met the requirements of meta‐analysis …”

Section: Resultsmentioning

confidence: 99%

The value of renal score in both determining surgical strategies and predicting complications for renal cell carcinoma: A systematic review and meta‐analysis

Shi

Zu²,

Shan

et al. 2020

Cancer Medicine

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Objectives: Radical nephrectomy (RN) was the standard treatment for renal cell carcinoma (RCC). However, recent studies have found that partial nephrectomy (PN) could achieve similar effects as radical nephrectomy, and has the advantages of less bleeding and shorter hospital stay. The choice of surgical strategies has become a concern of clinicians, which could be guided by renal score introduced by Kutikov et al Therefore, we conducted this meta-analysis to clarify the value of renal score of determining surgical strategies and predicting complications. Methods: The keywords "RENAL score," "renal nephrometry score," or "nephrometry score" were used to retrieve electronic databases for relevant literature up to Feb 2020, including PubMed, Web of Science, and the Cochrane library. Surgical strategies and complications are outcome measures. Risk ratio (RR) with 95% confidence intervals (CI) is applied to assess the effect size. Results: A total of 20 studies met the selection criteria for meta-analysis. There was significant difference in RN operation rate for each subgroup (low-moderate: RR = 3.50, 95% Cl = 2.60-4.71, P < .001; low-high: RR = 6.29, 95% Cl = 4.40-9.00, P < .001; moderate-high: RR = 1.80, 95% Cl = 1.39-2.32, P < .001).The overall incidence of complications from high renal score group was significantly higher than that in low renal score group (low-moderate: RR = 1.32, 95% Cl = 1.03-1.69, P = .026; low-high: RR = 2.45, 95% Cl = 1.48-4.07, P = .001; moderate-high: RR = 1.75, 95% Cl = 1.17-2.61, P = .007). Conclusions: This meta-analysis indicated that renal score is an efficient tool for determining surgical strategies and predicting complications in PN. More prospective research is essential to verify the predictive value of renal score. K E Y W O R D Scomplications, meta-analysis, Renal cell carcinoma, RENAL score, surgical strategiesThis is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Resultsmentioning

confidence: 99%

The value of renal score in both determining surgical strategies and predicting complications for renal cell carcinoma: A systematic review and meta‐analysis

Shi

Zu²,

Shan

et al. 2020

Cancer Medicine

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“…However, due to the widespread local recurrence, distant metastasis, and drug tolerance of RCC, the prognosis of RCC patients is not very optimistic (24). To improve RCC patients' prognosis and quality of life, more and more renal cancer surgery risk scoring standards and renal cancer prognostic risk stratification have been established (25)(26)(27). The prognosis of early RCC is relatively good.…”

Section: Discussionmentioning

confidence: 99%

A Web-Based Prediction Model for Cancer-Specific Survival of Middle-Aged Patients With Non-metastatic Renal Cell Carcinoma: A Population-Based Study

Tang

Wang

Pan

et al. 2022

Front. Public Health

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BackgroundRenal cell carcinoma (RCC) is one of the most common cancers in middle-aged patients. We aimed to establish a new nomogram for predicting cancer-specific survival (CSS) in middle-aged patients with non-metastatic renal cell carcinoma (nmRCC).MethodsThe clinicopathological information of all patients from 2010 to 2018 was downloaded from the SEER database. These patients were randomly assigned to the training set (70%) and validation set (30%). Univariate and multivariate COX regression analyses were used to identify independent risk factors for CSS in middle-aged patients with nmRCC in the training set. Based on these independent risk factors, a new nomogram was constructed to predict 1-, 3-, and 5-year CSS in middle-aged patients with nmRCC. Then, we used the consistency index (C-index), calibration curve, and area under receiver operating curve (AUC) to validate the accuracy and discrimination of the model. Decision curve analysis (DCA) was used to validate the clinical application value of the model.ResultsA total of 27,073 patients were included in the study. These patients were randomly divided into a training set (N = 18,990) and a validation set (N = 8,083). In the training set, univariate and multivariate Cox regression analysis indicated that age, sex, histological tumor grade, T stage, tumor size, and surgical method are independent risk factors for CSS of patients. A new nomogram was constructed to predict patients' 1-, 3-, and 5-year CSS. The C-index of the training set and validation set were 0.818 (95% CI: 0.802-0.834) and 0.802 (95% CI: 0.777-0.827), respectively. The 1 -, 3 -, and 5-year AUC for the training and validation set ranged from 77.7 to 80.0. The calibration curves of the training set and the validation set indicated that the predicted value is highly consistent with the actual observation value, indicating that the model has good accuracy. DCA also suggested that the model has potential clinical application value.ConclusionWe found that independent risk factors for CSS in middle-aged patients with nmRCC were age, sex, histological tumor grade, T stage, tumor size, and surgery. We have constructed a new nomogram to predict the CSS of middle-aged patients with nmRCC. This model has good accuracy and reliability and can assist doctors and patients in clinical decision making.

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“…The study was conducted at the Department of Urology, Sindh Institute of Urology & Transplantation, Karachi-Pakistan. Based on the least proportion of 16.3% 16 patients with a low score with a margin of error of 9% and 95% confidence level, a sample size of 63 was calculated. All male and female patients attending the study site for partial nephrectomy between 20 to 60 years of age were included.…”

Section: Methodsmentioning

confidence: 99%

Frequency of renal mass complexities among patients undergoing partial nephrectomy associated with perioperative blood loss.

Jameel

Jabeen

Saleem

et al. 2022

Int. j. endorsing health sci. res.

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Background: Partial nephrectomy has emerged as a standard treatment for managing small renal masses. RENAL Nephrometry score (RNS) is a widely used tool for assessing tumors, minimizing bias, and improving clinical outcomes. This study aimed to determine the frequency of various renal mass complexities based on the RENAL nephrometry score in patients undergoing partial nephrectomy and to compare the mean blood loss in these patients. Methodology: The cross-sectional study was conducted at the Department of Urology, Sindh Institute of Urology & Transplantation, Karachi- Pakistan. Perioperative blood loss after partial nephrectomy was observed in all cases, and patients had their RENAL nephrometry score determined before surgery. The patient's baseline demographic data, including age, gender, and body mass index (BMI), was recorded using a pre-designed Proforma. Results: According to the RNS, there were 33(52.4%) patients with moderate complexity, followed by 19(30.25%) and 11(17.4%) who had severe and mild complexity, respectively. Furthermore, there was a significant difference in the mean blood loss among the three groups (p=0.025). Among the cofounders, age, BMI, and male gender significantly affected mean blood loss in different RNS groups (p<0.05). Conclusion: There was a high frequency of moderate renal complexity among the studied patients based on the RNS. A significant difference in the mean blood loss was observed among the patients with mild, moderate, and severe complexity.

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Association between R.E.N.A.L nephrometry score and perioperative outcomes following open partial nephrectomy under cold ischemia

Cited by 8 publications

References 31 publications

The value of renal score in both determining surgical strategies and predicting complications for renal cell carcinoma: A systematic review and meta‐analysis

The value of renal score in both determining surgical strategies and predicting complications for renal cell carcinoma: A systematic review and meta‐analysis

A Web-Based Prediction Model for Cancer-Specific Survival of Middle-Aged Patients With Non-metastatic Renal Cell Carcinoma: A Population-Based Study

Frequency of renal mass complexities among patients undergoing partial nephrectomy associated with perioperative blood loss.

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