Association between Pulmonary Function and Sputum Biomarkers in Cystic Fibrosis

Mayer-Hamblett, Nicole; Aitken, Moira L.; Accurso, Frank J.; Kronmal, Richard A.; Konstan, Michael W.; Burns, Jane L.; Sagel, Scott D.; Ramsey, Bonnie W.

doi:10.1164/rccm.200609-1354oc

Cited by 199 publications

(207 citation statements)

References 24 publications

Supporting

Mentioning

193

Contrasting

Order By: Relevance

“…Desmosine and isodesmosine, amino acids found exclusively in cross-linked elastin and released by HLE-mediated proteolysis, are present at increased concentrations in the urine of CF patients when compared with healthy control subjects [32,41,42]. Patients with CF have high levels of active HLE in their sputum particularly during infectious respiratory exacerbations e levels of active HLE detected in the bronchoalveolar lavage uid of CF patients correlate signi cantly with pulmonary function indices of the severity of lung disease such as the FEV1 and the ratio of FEV1/FVC [14,32,44]. Lung secretion HLE is clearly an attractive surrogate marker for CF lung disease since it directly relates to an important pathogenic pathway in CF.…”

Section: Discussionmentioning

confidence: 99%

Plasma biomarkers and cystic fibrosis lung disease

Cantin

Bilodeau²,

Larivée³

et al. 2012

CIM

View full text Add to dashboard Cite

Plasma biomarkers and cystic brosis lung disease AbstractPurpose: e purpose of this study was to determine whether plasma biomarkers re ect changes in lung function and respiratory exacerbations associated with CF lung disease.Methods: Plasma human leukocyte elastase/alpha1 antitrypsin complex (pHLE complex) values were measured in 28 adult CF patients and 47 healthy volunteers and correlated with forced expiratory volume (FEV1) and forced vital capacity (FVC). pHLE complexes were studied during respiratory exacerbations and a er antibiotic therapy. Plasma cytokines and sialic acid were also measured.Results: pHLE complexes were increased in CF patients (p < 0.01), were inversely correlated with FEV1 (r = 0.71) and FVC (r = 0.67) and returned to normal levels a er intravenous antibiotics (p < 0.001). Plasma cytokines did not correlate with lung function. Total sialic acid increased during CF respiratory exacerbations and decreased a er antibiotic therapy.Conclusion: Plasma sialic acid and pHLE complexes re ect clinically meaningful changes in CF lung disease. In contrast, plasma cytokine levels did not correlate with lung function.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma biomarkers and cystic fibrosis lung disease

Cantin

Bilodeau²,

Larivée³

et al. 2012

CIM

View full text Add to dashboard Cite

show abstract

“…Airway inflammation is thought to be an independent risk factor for lung function decline and biomarkers of inflammation could potentially be used to define an at-risk population (15). Previous cross-sectional studies have provided evidence that sputum neutrophil elastase (NE) levels are higher in patients with severe lung disease (16) and elastase burden in bronchoalveolar lavage is correlated to lower lung function and bronchiectasis in infants with CF (17). In a longitudinal cohort study Sagel and colleagues demonstrated that elevated neutrophil elastase concentrations in sputum predict subsequent lung function decline and that longitudinal changes in NE are correlated to evolution of lung function (18).…”

Section: Airway Inflammation In Cfmentioning

confidence: 99%

Update in Cystic Fibrosis 2012

Goss

Ratjen

2013

Am J Respir Crit Care Med

View full text Add to dashboard Cite

“…With the recent development of disease-modifying treatments for CF, there is a need for noninvasive techniques to monitor disease development and progression in young children [3,4]. While lung function tests offer an alternative to invasive surveillance, studies correlating disease outcomes and respiratory function have predominantly been limited to those using spirometry [5][6][7] or techniques that require sedation [8][9][10][11][12][13][14], and there have been relatively few studies in preschool-aged children [8,[15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Impact of lung disease on respiratory impedance in young children with cystic fibrosis

et al. 2015

View full text Add to dashboard Cite

This study aimed to evaluate the ability of the forced oscillation technique (FOT) to detect underlying lung disease in preschool children with cystic fibrosis (CF) diagnosed following newborn screening.184 children (aged 3-6 years) with CF underwent lung function testing on 422 occasions using the FOT to assess respiratory resistance and reactance at the time of their annual bronchoalveolar lavage collection and chest computed tomography scan. We examined associations between FOT outcomes and the presence and progression of respiratory inflammation, infection and structural lung disease.Children with CF who had pronounced respiratory disease, including free neutrophil elastase activity, infection with pro-inflammatory pathogens and structural lung abnormalities had similar FOT outcomes to those children without detectable lung disease. In addition, the progression of lung disease over 1 year was not associated with worsening FOT outcomes.We conclude that the forced oscillation technique is relatively insensitive to detect underlying lung disease in preschool children with CF. However, FOT may still be of value in improving our understanding of the physiological changes associated with early CF lung disease. @ERSpublications Forced oscillation technique is insensitive in detecting lung disease in preschool children with cystic fibrosis http://ow.ly/R9rSU

show abstract

Association between Pulmonary Function and Sputum Biomarkers in Cystic Fibrosis

Abstract: These data support the role of sputum biomarkers as correlates of disease severity in a diverse CF population.

Cited by 199 publications

References 24 publications

Plasma biomarkers and cystic fibrosis lung disease

Plasma biomarkers and cystic fibrosis lung disease

Update in Cystic Fibrosis 2012

Impact of lung disease on respiratory impedance in young children with cystic fibrosis

Contact Info

Product

Resources

About