Association between pulmonary fibrosis and osteoporosis in the elderly people

Xie, Zhong; He, Yan‐Hong; Sun, Yu; Lin, Zhanzhan; Yang, Mingzhi; Liu, Qian; Liu, Sihai

doi:10.1097/md.0000000000005239

Cited by 4 publications

(8 citation statements)

References 28 publications

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“…As is briefly illustrated in Fig. 1 , out of the 1528 articles reviewed, 9 studies [ 7 – 10 , 24 – 28 ] from 5 countries finally met our eligibility. All studies were case–control and distinguished as high-quality by NOS assessment.…”

Section: Resultsmentioning

confidence: 99%

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

et al. 2021

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Background Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes mellitus (DM) in the past years but have failed to reach a consensus. This meta-analysis aimed to examine the association between diabetes to IPF. Methods We accumulated studies investigating the association between DM and IPF from databases including Medline, Cochrane Library, Embase, Web of Science, and China National Knowledge Infrastructure. RevMan 5.3 and the Newcastle–Ottawa Scale (NOS) were utilized to analyze the data and assess the quality of the included studies. The value of odds ratio (OR) with 95% confidence interval (CI) was used as the measure to estimate the risk of DM in IPF. Heterogeneity was assessed by I2 statistics. We also performed subgroup analysis, meta-regression, and Egger’s test for bias analysis. Results Nine case–control studies with 5096 IPF patients and 19,095 control subjects were included in the present meta-analysis, which indicated a positive correlation between DM and IPF (OR 1.65, 95% CI 1.30–2.10; P < 0.0001). Meta-regression and subgroup analysis negated the influence of covariates like cigarette smoking, age and gender, but the heterogeneity existed and could not be fully explained. Conclusion IPF and DM may be associated, but the causal relationship remains indeterminate till now. Further rigorously designed studies are required to confirm the present findings and investigate the possible mechanisms behind the effect of DM on IPF.

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Section: Resultsmentioning

confidence: 99%

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

et al. 2021

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“…All studies were case-control and distinguished as high-quality by NOS assessment. General population was selected as control groups in six studies [7,8,10,[25][26][27], one study included only healthy volunteers [24], and the remaining two [9,28] included patients with other chronic pulmonary diseases. IPF was diagnosed based on clinical history, HRCT, and lung biopsy while diagnosis of DM could be established with any objective method such as fasting blood glucose or simple by clinical symptoms combined with clinical history.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…All elements that could induce IPF were considered as potential sources of biases. Firstly, cigarette smoking is a known risk factor for IPF [29] and in the ve included studies [7,24,[26][27][28], smokers or ex-smokers were much more in case groups than in controls. In the following subgroup analysis (Table 2), when we selected the other four studies [8][9][10]25] in which the smoking habits between case and control groups were similar, the association remained statistically signi cant (OR: 1.52, 95% CI: 1.05-2.19; P = 0.02), which coincided with the outcome of the meta-regression (Fig.…”

Section: Bias Analysismentioning

confidence: 99%

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Idiopathic Pulmonary Fibrosis and Diabetes Mellitus: A Meta-Analysis and Systematic Review

Bai

Zhang

Pan

et al. 2021

Preprint

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Background: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes mellitus (DM) in the past years but have failed to reach a consensus. This meta-analysis aimed to examine the association between diabetes to IPF.Methods: We accumulated studies investigating the association between DM and IPF from databases including Medline, Cochrane Library, Embase, Web of Science, and China National Knowledge Infrastructure. RevMan 5.3 and the Newcastle-Ottawa Scale (NOS) were utilized to analyze the data and assess the quality of the included studies. The value of odds ratio (OR) with 95% confidence interval (CI) was used as the measure to estimate the risk of DM in IPF. Heterogeneity was assessed by I2 statistics. We also performed subgroup analysis, meta-regression, and Egger’s test for bias analysis. Results: Nine case-control studies with 5,096 IPF patients and 19,095 control subjects were included in the present meta-analysis, which indicated that DM could increase the risk of IPF (OR: 1.65, 95% CI: 1.30-2.10; P < 0.0001). Meta-regression and subgroup analysis negated the influence of covariates like cigarette smoking, age and gender, but the heterogeneity existed and could not be fully explained. Conclusion: The meta-analysis indicated that DM is highly probably related to IPF. Further rigorously designed studies are required to confirm the present findings and investigate the possible mechanisms behind the effect of DM on IPF.

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“…Growing evidence shows that fibrotic diseases such as pulmonary fibrosis or scleroderma can decrease BMD. In a case-control study of a hospital database, Xie et al [ 13 ] . reported that pulmonary fibrosis is a risk factor for osteoporosis independent of possible confounding factors.…”

Section: Introductionmentioning

confidence: 99%

The association between keloid and osteoporosis: real-world evidence

Qin

Zhang

et al. 2021

BMC Musculoskelet Disord

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Background Keloids are characterized by disturbance of fibroblast proliferation and apoptosis, deposition of collagen, and upregulation of dermal inflammation cells. This benign dermal fibro-proliferative scarring condition is a recognized skin inflammation disorder. Chronic inflammation is a well-known contributor to bone loss and its sequelae, osteoporosis. They both shared a similar pathogenesis through chronic inflammation. We assessed whether keloids increase osteoporosis risk through using National Health Insurance Research Database. Methods The 42,985 enrolled patients included 8597 patients with keloids but no history of osteoporosis; 34,388 controls without keloids were identified from the general population and matched at a one-to-four ratio by age, gender. Kaplan-Meier method was applied to determine cumulative incidence of osteoporosis. Cox proportional hazard regression analysis was performed after adjustment of covariates to estimate the effect of keloids on osteoporosis risk. Results Of the 8597 patients with keloids, 178 (2.07%) patients were diagnosed with osteoporosis while in the 34,388 controls, 587 (1.71%) were diagnosed with osteoporosis. That is, the keloids patients had 2.64-fold higher risk of osteoporosis compared to controls after adjustment for age, gender, Charlson Comorbidity Index and related comorbidities. The association between keloids and osteoporosis was strongest in patients younger than 50 years (hazard ratio = 7.06%) and in patients without comorbidities (hazard ratio = 4.98%). In the keloids patients, a high incidence of osteoporosis was also associated with advanced age, high Charlson Comorbidity Index score, hyperlipidemia, chronic liver disease, stroke, and depression. Conclusions Osteoporosis risk was higher in patients with keloids compared to controls, especially in young subjects and subjects without comorbidities.

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Association between pulmonary fibrosis and osteoporosis in the elderly people

Cited by 4 publications

References 28 publications

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

Idiopathic Pulmonary Fibrosis and Diabetes Mellitus: A Meta-Analysis and Systematic Review

The association between keloid and osteoporosis: real-world evidence

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