Association Between Psoriasis and Depression: A Traditional Review

Sahi, Faryal Mustansir; Masood, Ayesha; Danawar, Nuaman A; Mekaiel, Andrew; Malik, Bilal Haider

doi:10.7759/cureus.9708

Cited by 38 publications

(38 citation statements)

References 46 publications

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“…A recent meta-analysis found that patients with psoriasis appear to have a slightly increased risk of cancer, particularly keratinocyte cancer and lymphomas, although data for National and International Registries on treatment with biologic agents did not show an increased risk of cancer, and data on cancer in patients with psoriatic arthritis remain inconclusive [ 104 ]. The prevalence of having depression or anxiety is higher in psoriasis patients than in controls, and TNF-α could be a pathophysiologic link between the two conditions [ 105 , 106 ].…”

Section: Resultsmentioning

confidence: 99%

Psoriasis as an Immune-Mediated and Inflammatory Systemic Disease: From Pathophysiology to Novel Therapeutic Approaches

et al. 2021

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Psoriasis is an immune-mediated inflammatory disease, with a chronic relapsing-remitting course, which affects 2–3% of the worldwide population. The progressive acquisitions of the inflammatory pathways involved in the development of psoriasis have led to the identification of the key molecules of the psoriatic inflammatory cascade. At the same time, psoriasis therapy has radically evolved with the introduction of target molecules able to modify the natural history of the disease, acting specifically on these inflammatory pathways. For these reasons, biologics have been demonstrated to be drugs able to change the disease’s natural history, as they reduce the inflammatory background to avoid irreversible organ damage and prevent systemic complications. However, several issues related to the use of biologics in patients with systemic comorbidities, remain open. All these data reflect the extraordinary potentiality of biologics, but also the unmet medical need to improve our knowledge on the long-term risk related to continuous use of these drugs, and their administration in special populations. This narrative review aims to highlight both the efficacy and safety profile of biologics in psoriasis, starting from pathophysiology and moving towards their clinical application.

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Section: Resultsmentioning

confidence: 99%

Psoriasis as an Immune-Mediated and Inflammatory Systemic Disease: From Pathophysiology to Novel Therapeutic Approaches

et al. 2021

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“…Patients with psoriasis who show high levels of cytokines, Th17 cells and IL-17A, are more subjected to develop depression and anxiety disorders [ 144 ]. These data suggest a strong correlation between depression and the immune system; therefore, a relationship between depression and psoriasis may be hypothesized [ 157 ]: depression improvement might be observed following treatment of psoriasis, and conversely, depression treatment might improve psoriasis symptoms [ 157 ].…”

Section: Psoriasis-related Psychological Alterationsmentioning

confidence: 99%

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

et al. 2022

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Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%–3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.

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“…The higher prevalence of obesity in psoriasis patients may be related not only to the overproduction of pro-inflammatory factors, but also to the fact that psoriasis is often accompanied by stigma and prolonged stress, which often lead to reduced levels of physical activity as well as adverse changes in eating habits and broader lifestyle. These, in turn, may contribute to weight gain [ 26 , 27 ].…”

Section: Obesitymentioning

confidence: 99%

“…On the other hand, obesity may contribute to lower self-esteem, increased stress levels, and even the development or worsening of depression and anxiety disorders [ 26 ]. The relationship between psoriasis and obesity in a psychological context is shown in Figure 1 .…”

Section: Obesitymentioning

confidence: 99%

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Nutritional Therapy in Persons Suffering from Psoriasis

et al. 2021

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Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental factors, including diet, play a part in the pathogenesis of psoriasis. Metabolic syndrome or its components are frequent co-morbidities in persons with psoriasis. A change of eating habits can improve the quality of life of patients by relieving skin lesions and by reducing the risk of other diseases. A low-energy diet is recommended for patients with excess body weight. Persons suffering from psoriasis should limit the intake of saturated fatty acids and replace them with polyunsaturated fatty acids from the omega-3 family, which have an anti-inflammatory effect. In diet therapy for persons with psoriasis, the introduction of antioxidants such as vitamin A, vitamin C, vitamin E, carotenoids, flavonoids, and selenium is extremely important. Vitamin D supplementation is also recommended. Some authors suggest that alternative diets have a positive effect on the course of psoriasis. These diets include: a gluten-free diet, a vegetarian diet, and a Mediterranean diet. Diet therapy for patients with psoriasis should also be tailored to pharmacological treatment. For instance, folic acid supplementation is introduced in persons taking methotrexate. The purpose of this paper is to discuss in detail the nutritional recommendations for persons with psoriasis.

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Association Between Psoriasis and Depression: A Traditional Review

Cited by 38 publications

References 46 publications

Psoriasis as an Immune-Mediated and Inflammatory Systemic Disease: From Pathophysiology to Novel Therapeutic Approaches

Psoriasis as an Immune-Mediated and Inflammatory Systemic Disease: From Pathophysiology to Novel Therapeutic Approaches

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

Nutritional Therapy in Persons Suffering from Psoriasis

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