Association between pseudodrusen and delayed patchy choroidal filling in the comparison of age‐related macular degeneration treatments trials

Zhou, Qiang; Daniel, Ebenezer; Grunwald, Juan E.; Maguire, Maureen G.; Gewaily, Dina; Martín, Daniel; Ying, Gui Shuang

doi:10.1111/aos.13398

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…Many authors have reported thinning of the choroid in eyes with SDD, as observed with OCT, but it is not yet clear if choroidal vasculature alterations are a primary pathogenetic factor [5,6,11,12,16,20,21]. Our data did not show significant choroidal thinning in eyes with SDD.…”

Section: Discussioncontrasting

confidence: 54%

“…Spaide et al used enface SDOCT but did not report diffuse alterations of the choriocapillaris layer [12]. However, recently it was reported that choroidal filling defects during angiography were more frequent in eyes with pseudodrusen [21]. Mrejan and Spaide, retrospectively investigated highly myopic eyes with reduced choroidal thickness but did not find development of SDD concluding that there is no conclusive evidence to support a causative relationship between choroidal thickness and SDD formation [16].…”

Section: Discussionmentioning

confidence: 99%

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Optical coherence tomography evidence of macular ganglion cell-inner plexiform layer thinning in eyes with subretinal drusenoid deposits

Abdolrahimzadeh

Parisi

Marcelli

et al. 2019

Eye

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Background/Objectives The purpose of this study was to evaluate macular ganglion cell layer-inner plexiform layer (GCL-IPL) and choroidal thickness in early age-related macular degeneration (AMD) in eyes with subretinal drusenoid deposits (SDD). Subjects/Methods Comprehensive ophthalmological examination was performed. Near infrared reflectance and raster images using enhanced depth imaging were acquired with spectral domain optical coherence tomography. Drusen and SDD were diagnosed based on raster scans and near infrared reflectance. GCL-IPL maps were generated with automated segmentation and choroidal thickness maps were obtained by manually delineating the choroid-scleral boundary. Results Forty-eight eyes from 48 patients (mean age 77.5 ± 5.7, range 68-90 years) with a diagnosis of early AMD and 42 eyes of 42 age-matched control subjects (mean age 76.9 ± 5.7, range 67-88 years) were included. Of these, 28 eyes (58.3%) had drusen alone, 4 eyes (8.3%) had SDD alone, and 16 eyes (33.3%) had drusen associated with SDD. Compared with controls, average choroidal thickness was significantly decreased in AMD eyes (P < 0.05). There was no significant difference in choroidal thickness in eyes with SDD with respect to those with drusen alone. GCL-IPL thickness was reduced in an annular pattern at the 3 and 6 mm macular areas in AMD patients with respect to controls (P < 0.05). GCL-IPL thickness at 3 mm was significantly reduced in eyes with SDD with respect to those with drusen alone (P = 0.03). Conclusions The GCL-IPL is reduced in thickness with an annular pattern in early AMD and is significantly thinner in eyes with SDD.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography evidence of macular ganglion cell-inner plexiform layer thinning in eyes with subretinal drusenoid deposits

Abdolrahimzadeh

Parisi

Marcelli

et al. 2019

Eye

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“…In addition, a severity classification based on fundus photography was developed 16 . Again, OCT angiography was not included in classification systems as yet, although a wide variety of studies indicate that choroidal perfusion abnormalities are associated with the risk of disease progression [225][226][227][228][229] .…”

Section: Potential Challengesmentioning

confidence: 99%

Deep learning in ophthalmology: The technical and clinical considerations

Ting

Peng

Varadarajan

et al. 2019

Progress in Retinal and Eye Research

345

237

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“…Two longitudinal studies have shown that low CBF is a risk factor for the development of choroidal neovascularisation 11 12. In the Comparison of Age-related Macular Degeneration Treatment Trials (CATT) study, patchy choroidal filling was identified as an important risk factor for vision loss during anti-vascular endothelial growth factor (VEGF) therapy 13. A variety of OCTA provided links between choroidal vascular changes and different stages of AMD 14–17…”

Section: Introductionmentioning

confidence: 99%