Association between prostate specific antigen levels and coronary artery angioplasty

Abstract

Introduction: Prostate-specific antigen (PSA) is a protein, whose serum levels changes during various physiologic and pathologic situations. Recently, the relationship between PSA and cardiologic disorders has been assessed. Objectives: The purpose of this study was to assess the association of percutaneous coronary intervention (PCI) complications with PSA serum levels. Patients and Methods: In this study, 100 eligible patients undergoing PCI were included. The total PSA serum values were analyzed pre- and post-procedure. The association between PSA levels with age, gender, inflammatory (C-reactive protein [CRP] and white blood cell [WBC]), cardiogenic (troponin, CK-MB, echocardiography and angiography results), and nephrology (creatinine) properties was investigated. Results: Changes in the level of PSA pre- and post-PCI was not significant (P=0.2). However, based on the pathology, patients with acute coronary syndrome (ACS) had a significant difference in the levels of PSA compared to cases of stable ischemic heart disease (SIHD) (P=0.008). Moreover, the effect of gender on the changes in PSA level following PCI was conclusive. There was no association between the direct effect of PCI parameters or PCI complications on PSA level changes. Conclusion: The results showed that PSA levels were affected by the etiology of cardiac disorders instead of therapeutic methods like PCI.

Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels with Overdosed Dietary Zinc

“…PCa screening based on the measurement of PSA levels using an annual PSA test was approved in 1995 by the US Food and Drug Administration (FDA), and these standards have been widely used in the clinic for PCa screening and surveillance [17]. Studies have shown that the serum PSA level is not a strong indicator for the presence of PCa, with only a 24% positive predictive value [9][10]; this is because serum PSA levels are subject to many factors, including disease, age, smoking status, alcohol intake, as well as others [11][12][13][14][15][16], which may interfere with a de nitive diagnosis of PCa. Nevertheless, Tikkinen et al still recommend using serum PSA as a criterion for PCa screening and surveillance, which has positive implications for early detection and prevention of the disease [17].…”