Association between promoter methylation and gene expression of <i>CGB3</i> and <i>NOP56</i> in HPV‑infected cervical cancer cells

Singh, Palak; Chalertpet, Kanwalat; Sukbhattee, Juthamard; Wongmanee, Nannabhat; Suwannakart, Pimwipa; Yanatatsaneejit, Pattamawadee

doi:10.3892/br.2021.1484

Cited by 8 publications

(11 citation statements)

References 45 publications

(65 reference statements)

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“…However, the size of our study population is not large enough to draw definitive conclusions. Recently, it was shown that HPV16 E7 induced promoter-methylation and decreased CGB3 gene expression, which may cause the absence or lower levels of hCGβ-immunostaining in HPV-positive tumors [ 41 ]. Interestingly, the Cox regression analysis showed a significant independent correlation between reduced DSS and S-hCGβ ( Table 2 .).…”

Section: Discussionmentioning

confidence: 99%

The Role of Human Chorionic Gonadotropin Beta (hCGβ) in HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma

Sjöblom

Carpén

Stenman

et al. 2022

Cancers

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Background: This study was carried out to observe the upregulation of the free β-subunit of human chorionic gonadotropin (hCGβ) and its prognostic significance in human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC). Materials and methods: A total of 90 patients with OPSCC treated with curative intent at the Helsinki University Hospital (HUS), Helsinki, Finland, during 2012–2016 were included. Serum samples were collected prospectively, and their hCGβ concentrations (S-hCGβ) were determined by an immunofluorometric assay. The expression of hCGβ in tumor tissues was defined by immunohistochemistry (IHC). HPV determination was performed by combining p16-INK4 IHC and HPV DNA PCR genotyping. Overall survival (OS) and disease-specific survival (DSS) were used as survival endpoints. Results: S-hCGβ positivity correlated with poor OS in the whole patient cohort (p < 0.001) and in patients with HPV-negative OPSCC (p < 0.001). A significant correlation was seen between S-hCGβ and poor DSS in the whole cohort (p < 0.001) and in patients with HPV-negative OPSCC (p = 0.007). In a multivariable analysis, S-hCGβ was associated with poor DSS. Of the clinical characteristics, higher cancer stage and grade were associated with S-hCGβ positivity. No statistically significant correlation with tissue positivity of hCGβ was seen in these analyses. Conclusion: S-hCGβ may be a potential independent factor indicating poor prognosis, notably in HPV-negative OPSCC.

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Section: Discussionmentioning

confidence: 99%

The Role of Human Chorionic Gonadotropin Beta (hCGβ) in HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma

Sjöblom

Carpén

Stenman

et al. 2022

Cancers

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“…Human papillomavirus (HPV) infection is considered an important risk factor for cervical cancer development. Two viral oncoproteins, E6 and E7, alter cellular DNA methylation of tumour suppressor genes, such as CCNA1 , CADM1 and DAPK1 , through the formation of a complex with DNMT1 and probably with transcription factors ( Woodman et al., 2007 ; Yanatatsaneejit et al., 2020 ; Singh et al., 2022 ). HPV-linked methylation aberrations are useful for prognosis and identification of cervical cancer subtypes ( Yang et al., 2020 ).…”

Section: Association Between Infectious Diseases and Cancermentioning

confidence: 99%

“…Gastric cancer (Cheng et al, 2013 (Woodman et al, 2007;Yanatatsaneejit et al, 2020;Singh et al, 2022)…”

Section: Helicobacter Pylorimentioning

confidence: 99%

“…Cell adhesion protein; cell junction organizer Human papillomavirus Cervical cancer (Yanatatsaneejit et al, 2020;Singh et al, 2022) DAPK1 (death associated protein kinase 1)…”

Section: Cadm1 (Cell Adhesion Molecule 1)mentioning

confidence: 99%

“…Cervical cancer (Yanatatsaneejit et al, 2020;Singh et al, 2022) Altered DNMTs (DNA Methyltransferases) During acute and chronic infection, amastigotes ensure their survival within phagolysosomes developing semi-quiescent and dormant stages, i.e. reducing or shutting down expensive metabolic processes and maintaining a slow or very slow growth (Saunders et al, 2021).…”

Section: Apoptosis Inducer Human Papillomavirusmentioning

confidence: 99%

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DNA methylation alterations caused by Leishmania infection may generate a microenvironment prone to tumour development

Vega-Benedetti

Loi

Zavattari

2022

Front. Cell. Infect. Microbiol.

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DNA methylation is an epigenetic signature consisting of a methyl group at the 5’ cytosine of CpG dinucleotides. Modifications in DNA methylation pattern have been detected in cancer and infectious diseases and may be associated with gene expression changes. In cancer development DNA methylation aberrations are early events whereas in infectious diseases these epigenetic changes may be due to host/pathogen interaction. In particular, in leishmaniasis, a parasitic disease caused by the protozoan Leishmania, DNA methylation alterations have been detected in macrophages upon infection with Leishmania donovani and in skin lesions from patients with cutaneous leishmaniasis. Interestingly, different types of cancers, such as cutaneous malignant lesions, lymphoma and hepatocellular carcinoma, have been diagnosed in patients with a history of leishmaniasis. In fact, it is known that there exists an association between cancer and infectious diseases. Leishmania infection may increase susceptibility to develop cancer, but the mechanisms involved are not entirely clear. Considering these aspects, in this review we discuss the hypothesis that DNA methylation alterations induced by Leishmania may trigger tumorigenesis in long term infection since these epigenetic modifications may enhance and accumulate during chronic leishmaniasis.

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Advances in epigenetic modifications and cervical cancer research

Liu¹,

Ma²,

Li³

et al. 2023

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Association between promoter methylation and gene expression of CGB3 and NOP56 in HPV‑infected cervical cancer cells

Cited by 8 publications

References 45 publications

The Role of Human Chorionic Gonadotropin Beta (hCGβ) in HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma

The Role of Human Chorionic Gonadotropin Beta (hCGβ) in HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma

DNA methylation alterations caused by Leishmania infection may generate a microenvironment prone to tumour development

Advances in epigenetic modifications and cervical cancer research

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