Association between PRO12ALa Polymorphism of PARγ2 Gene and Coronary Artery Disease in Iranian Population with Type Two Diabetes Mellitus

Saremi, Leila; Lotfıpanah, Shirin; Feizy, Fatemeh; Ghaffari, Mohammad Ebrahim; Babaniamansour, Sepideh; Saltanatpour, Zohreh

doi:10.4183/aeb.2022.139

Cited by 1 publication

(1 citation statement)

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“…PPAR-γ2 rs1801282-CG + GG minor allele carriers had higher values of TG in subjects with obesity, whereas they were lower in T2D patients from Australian and Russian populations, respectively [47,48]. In contrast, FPG, cholesterol, and TG were lower in patients with the rs1801282-CG genotype compared to the homozygous CC in an Iranian population with coronary artery disease (CAD) and T2D [49]. Of note, the levels of these biomarkers were lower than those found in our study, and given the antecedent of CAD, probably received different pharmacological treatment.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Biomarkers in Adults with Type 2 Diabetes: The Role of PPAR-γ2 and PPAR-β/δ Polymorphisms

Reza-López,

González-Gurrola,

Morales-Morales

et al. 2023

Biomolecules

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Glucose and lipid metabolism regulation by the peroxisome proliferator-activated receptors (PPARs) has been extensively reported. However, the role of their polymorphisms remains unclear. Objective: To determine the relation between PPAR-γ2 rs1801282 (Pro12Ala) and PPAR-β/δ rs2016520 (+294T/C) polymorphisms and metabolic biomarkers in adults with type 2 diabetes (T2D). Materials and Methods: We included 314 patients with T2D. Information on anthropometric, fasting plasma glucose (FPG), HbA1c and lipid profile measurements was taken from clinical records. Genomic DNA was obtained from peripheral blood. End-point PCR was used for PPAR-γ2 rs1801282, while for PPAR-β/δ rs2016520 the PCR product was digested with Bsl-I enzyme. Data were compared with parametric or non-parametric tests. Multivariate models were used to adjust for covariates and interaction effects. Results: minor allele frequency was 12.42% for PPAR-γ2 rs1801282-G and 13.85% for PPAR-β/δ rs2016520-C. Both polymorphisms were related to waist circumference; they showed independent effects on HbA1c, while they interacted for FPG; carriers of both PPAR minor alleles had the highest values. Interactions between FPG and polymorphisms were identified in their relation to triglyceride level. Conclusions: PPAR-γ2 rs1801282 and PPAR-β/δ rs2016520 polymorphisms are associated with anthropometric, glucose, and lipid metabolism biomarkers in T2D patients. Further research is required on the molecular mechanisms involved.

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Section: Discussionmentioning

confidence: 99%