Association Between Presence of Virulence Genes and Antibiotic Resistance in Clinical<i>Klebsiella Pneumoniae</i>Isolates

Derakhshan, Safoura; Peerayeh, Shahin Najar; Bakhshi, Bita

doi:10.1093/labmed/lmw030

Cited by 39 publications

(32 citation statements)

References 24 publications

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“…The resistance rate to trimethoprimsulfamethoxazole was significantly lower than 39%, 55.5%, 39.3%, 50%, 51.5%, and 54% reported by Peerayeh (31). The resistance rate to cefepime was significantly higher than 12.9% reported by Liu et al (31), yet in accordance with 37.5% reported by Peerayeh et al (26), also significantly lower than 80.5% and 57% reported by Peerayeh et al (26) and Derakhshan et al (34).…”

Section: Discussionsupporting

confidence: 60%

“…The resistance rate to imipenem was significantly higher than 1.4% and 0.05% reported by Liu et al (31), and Derakhshan et al (34), and also reports of Shahcheraghi et al (25), Peerayeh et al (26), Derakhshan et al (27), Peerayeh et al (28), and Ranjbar et al (35), which reported no resistance to imipenem, yet significantly lower than 20.8% reported by Amraie et al (36). The resistance rate to ciprofloxacin was significantly lower than 44.4%, 37.1%, 42.5%, and 52.5% reported by Derakhshan et al 27 The resistance rate to nitrofurantoin was significantly lower than 40% and 71% reported by Ranjbar et al (35) and Amraie et al (36).…”

Section: Discussionmentioning

confidence: 48%

“…Frequency of rmpA was significantly higher than 5.5%, 3.6%, and 7.0% reported by Derakhshan et al (27), Maatallah et al (33), and Derakhshan et al, respectively (34). Frequency of wcaG was significantly higher than 2.7% and 8.6% reported by Derakhshan et al (27) and Maatallah et al (33), yet significantly lower than 23.5% reported by Derakhshan et al (34).…”

Section: Discussionmentioning

confidence: 58%

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Evaluation of Virulence Factors and Antibiotic Resistance Patterns in Clinical Urine Isolates of Klebsiella pneumoniae in Semnan, Iran

Moghadas

Kalantari²,

Sarfi

et al. 2018

Jundishapur J Microbiol

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Background: Klebsiella pneumoniae as an opportunistic pathogen can be the cause of a range of nosocomial and community-acquired infections. Many virulence factors help these bacteria overcome an immune system and cause various diseases. K1 and K2 capsular antigens, also magA, wcaG, and rmpA are well-known K. pneumoniae virulence factors. Klebsiella pneumoniae has been revealed to have the ability to acquire resistance to many antibiotics, which cause treatment failure. Objectives: This study aimed at determining the prevalence of magA, wcaG, rmpA, Capsular type K1, Capsular type K2, TEM, and SHV in K. pneumoniae isolates. Methods: A total of 173 non-duplicate K. pneumoniae isolates were collected from two different hospitals in Semnan, Iran, from urine specimens. Klebsiella pneumoniae was identified by conventional bacteriological tests. Disk diffusion test was performed according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI). Detection of virulence factors, TEM, and SHV gene was performed by specific primers.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 58%

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Evaluation of Virulence Factors and Antibiotic Resistance Patterns in Clinical Urine Isolates of Klebsiella pneumoniae in Semnan, Iran

Moghadas

Kalantari²,

Sarfi

et al. 2018

Jundishapur J Microbiol

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“…Interestingly some major ST K. pneumoniae strains, even though showing an MDR phenotype, may harbor more virulence genes than some more susceptible isolates. However, several groups who investigated the integron content in the isolates reported that an extra virulence gene load is significantly associated with the carriage of type 1 integrons conferring resistance to antibiotics (Derakhshan et al, 2016;Xu et al, 2017;Zaki, 2019). Though the promoter types of K. pneumoniae integrons have not been investigated to date it is well-established that type 1 integrons usually contain weak promoters in E. coli (Vinué et al, 2011;Wei et al, 2013).…”

Section: The Virulence Component In Mdr K Pneumoniaementioning

confidence: 99%

Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents

2020

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“…Derakhshan et al compared the occurrence of rmpA and wcaG genes with the production of class 1 integron (intl1) among K. pneumoniae strains isolated from clinical specimens. The prevalence of wcaG was more frequent in the intl1 producing K. pneumoniae (21). The findings of this study indicated that the numbers of wabG-carrying isolates were more common in strains producing the bla CTX-M-15 gene (P < 0.05).…”

Section: Discussionmentioning

confidence: 56%

Comparative Prevalence of blaCTX-M-15 Gene with Virulence Genes and Serotypes in Klebsiella pneumoniae

Alizade

Jajarmi

Aflatoonian

et al. 2018

Jundishapur J Microbiol

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Background: A newly emerged hypervirulent strain of Klebsiella pneumoniae has caused great concern globally; however, its molecular characteristics have been rarely reported in Iran. Objectives: The goal of this study was to detect the virulence determinants and serotypes of K. pneumoniae and to evaluate the association among selected virulence traits and blaCTX-M-15 gene in southeastern Iran. Methods: One hundred and three non-duplicate K. pneumoniae strains were isolated from clinical samples. The isolates were identified by standard bacteriological tests. Confirmed isolates were examined to detect a selection of virulence genes (wabG, rmpA and iucB) and serotypes (K1, K2, K5 and K20) by PCR. The isolates were studied foe the presence of beta-lactamase (blaCTX-M-15) gene. SPSS software (version 19.0) was used for data analysis. Results: Among the 103 K. pneumoniae isolates, 61 (59.2%) isolates were positive for wabG, 4 (3.9%) for iucB and 3 (2.9%) for rmpA genes. The presence of K20 in 3.9% (4/103) of the isolates represented the most prevalent. Only 3 (2.9%) isolates possessed the K1 serotype, while K2 and K5 serotypes were not detected in any isolate. The blaCTX-M-15 gene was detected in 47 (45.6%) isolates. blaCTX-M-15-positive isolates showed a higher prevalence of wabG among the studied isolates (P < 0.05). Conclusions: Our data indicate a correlation between presence of virulence gene and blaCTX-M-15 in K. pneumonia isolates. Further research should be undertaken to unravel aspects of both virulence factors and antibiotic resistance which may probably contribute to managing future spread of infectious diseases.

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Association Between Presence of Virulence Genes and Antibiotic Resistance in ClinicalKlebsiella PneumoniaeIsolates

Abstract: Our results showed a correlation between presence of virulence gene and antibiotic resistance in K. pneumoniae.

Cited by 39 publications

References 24 publications

Evaluation of Virulence Factors and Antibiotic Resistance Patterns in Clinical Urine Isolates of Klebsiella pneumoniae in Semnan, Iran

Evaluation of Virulence Factors and Antibiotic Resistance Patterns in Clinical Urine Isolates of Klebsiella pneumoniae in Semnan, Iran

Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents

Comparative Prevalence of blaCTX-M-15 Gene with Virulence Genes and Serotypes in Klebsiella pneumoniae

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