Association between prenatal psychological stress and oxidative stress during pregnancy

Eick, Stephanie M.; Barrett, Emily S.; Erve, Thomas J. van ‘t; Nguyen, Ruby H.N.; Bush, Nicole R.; Milne, Ginger L.; Swan, Shanna H.; Ferguson, Kelly K.

doi:10.1111/ppe.12465

Cited by 41 publications

(39 citation statements)

References 35 publications

(75 reference statements)

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“…Our final model was a priori adjusted for maternal education (�college degree yes/no), maternal race/ethnicity (non-Hispanic white yes/no), and maternal age at enrollment. These variables were chosen based on their known associations with psychosocial stressors during pregnancy [9].…”

Section: Resultsmentioning

confidence: 99%

“…Psychosocial stress and responses to stress during pregnancy may contribute to the persistence of disparities in adverse birth outcomes across socioeconomic and racial and ethnic groups. For example, research from a multi-center pregnancy cohort indicated that roughly 50% of women with less than a college degree reported experiencing at least one stressful life event during pregnancy, compared to only 33% of women who had completed college [9]. However, stressful life events were not associated with preterm birth in that cohort [24].…”

Section: Introductionmentioning

confidence: 99%

“…There are a number of stressful experiences during pregnancy that have been shown to adversely affect maternal and fetal health, including financial hardship, the death of a family member, or experiences with racial discrimination, and women are often exposed to a multitude of these stressors during pregnancy [5][6][7][8]. Certain indicators of psychosocial stress are prevalent during pregnancy, with 39% of women experiencing a stressful life event in the year prior to pregnancy [9] and estimates of depressive symptoms during pregnancy at approximately 25% [10]. Studies have examined diverse psychosocial stressors individually in relation to birth outcomes [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Relationships between psychosocial stressors among pregnant women in San Francisco: A path analysis

et al. 2020

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Pregnant women who experience psychosocial stressors, such as stressful life events, poor neighborhood quality, and financial hardship, are at an increased risk for adverse pregnancy outcomes. Yet, few studies have examined associations between multiple stressors from different sources, which may be helpful to better inform causal pathways leading to adverse birth outcomes. Using path analysis, we examined associations between multiple selfreported stressor exposures during and before pregnancy in the Chemicals in Our Bodies-2 study (N = 510), a demographically diverse cohort of pregnant women in San Francisco. We examined associations between eight self-reported exposures to stressors and three responses to stress which were assessed via interview questionnaire at the 2 nd trimester. Stressors included: neighborhood quality, stressful life events, caregiving, discrimination, financial strain, job strain, food insecurity, and unplanned pregnancy. Perceived stress, depression, and perceived community status were included as indicators of self-reported stress response. Our model indicated that women who experienced discrimination and food insecurity had a 3.76 (95% confidence interval [CI] = 1.60, 5.85) and 2.67 (95% CI = 1.31, 4.04) increase in depression scale scores compared to women who did not experience discrimination and food insecurity, respectively. We additionally identified job strain and caregiving for an ill family member as strong predictors of increased depressive symptoms (β = 1.63, 95% CI = 0.29, 3.07; β = 1.48, 95% CI = 0.19, 2.70, respectively). Discrimination, food insecurity, and job strain also influenced depression indirectly through the mediating pathway of increasing perceived stress, although indirect effects were less precise. In our study population, women who experienced discrimination, food insecurity, job strain and caregiving for an ill family member had an increased number of depressive symptoms compared to women who did not experience these stressors. Results from our study highlight the complex relationships between stressors and stress responses and may help to identify possible mediating pathways leading to adverse pregnancy outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationships between psychosocial stressors among pregnant women in San Francisco: A path analysis

et al. 2020

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“…Associations between the oxidative stress biomarkers and demographic characteristics are presented in Supplemental Table 3 and have been previously discussed for this study population. 23 Adjusted associations between the three measured urinary oxidative stress biomarkers and urinary phthalate and DINCH metabolites are presented in Table 4. All phthalates metabolites except for MEP had significant positive associations with 8-iso-PGF 2α .…”

Section: Resultsmentioning

confidence: 99%

Phthalates and Phthalate Alternatives Have Diverse Associations with Oxidative Stress and Inflammation in Pregnant Women

Erve

Rosen

Barrett

et al. 2019

Environ. Sci. Technol.

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“…It is hypothesized that psychosocial stress contributes to PTB through activation of the hypothalamic-pituitary-adrenal (HPA) axis, which increases cortisol production [5]. Psychosocial stress may also increase oxidative stress and inflammation, which are increased in mothers who go on to experience PTB [5,[31][32][33]. Additionally, psychosocial stress may lead to unhealthy behaviors, such as smoking or poor nutrition, which may increase the risk of PTB through these or other pathways [5].…”

Section: Discussionmentioning

confidence: 99%

Relationships between psychosocial factors during pregnancy and preterm birth in Puerto Rico

et al. 2020

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Psychosocial stress during pregnancy has been associated with adverse pregnancy outcomes including preterm birth (PTB). This has not been studied in Puerto Rico, an area with high PTB rates. Our objective was to develop a conceptual model describing the interrelationships between measures of psychosocial stress and depression, a result of stress, among pregnant women in Puerto Rico and to examine their associations with PTB. We used data from the Puerto Rico Testsite for Exploring Contamination Threats pregnancy cohort (PROTECT, N = 1,047) to examine associations among depression and different continuous measures of psychosocial stress using path analysis. Psychosocial stress during pregnancy was assessed using validated measures of perceived stress, negative life experiences, neighborhood perceptions and social support. Logistic regression was used to examine associations between psychosocial stress measures in tertiles and PTB. Perceived stress, negative life experiences, and neighborhood perceptions influenced depression through multiple pathways. Our model indicated that perceived stress had the strongest direct effect on depression, where one standard deviation (SD) increase in perceived stress was associated with a 57% SD increase in depression. Negative life experiences were directly but also indirectly, through perceived stress, associated with depression. Finally, neighborhood perceptions directly influenced negative life experiences and perceived stress and consequently had an indirect effect on depression. Psychosocial stress was not associated with PTB across any of the measures examined. Our study examined interrelationships between multiple measures of psychosocial stress and depression among a pregnant Puerto Rican population and identified negative neighborhood perceptions as important upstream factors leading to depression. Our findings highlight the

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Association between prenatal psychological stress and oxidative stress during pregnancy

Cited by 41 publications

References 35 publications

Relationships between psychosocial stressors among pregnant women in San Francisco: A path analysis

Relationships between psychosocial stressors among pregnant women in San Francisco: A path analysis

Phthalates and Phthalate Alternatives Have Diverse Associations with Oxidative Stress and Inflammation in Pregnant Women

Relationships between psychosocial factors during pregnancy and preterm birth in Puerto Rico

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