Association between prenatal exposure to persistent organic pollutants and neurodevelopment in early life: A mother-child cohort (Shanghai, China)

Wang, Susu; Hu, Chunping; Lu, An-Xin; Wang, Yaqian; Cao, Linfeng; Wu, Wei; Li, Hui; Wu, Meiqin; Yan, Chen‐Hua

doi:10.1016/j.ecoenv.2020.111479

Cited by 17 publications

(4 citation statements)

References 48 publications

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“…Air pollution has been extensively studied as a direct cause of child health problems, such as adverse birth outcomes, impaired cognitive and behavioral development ( 15 – 17 ), and respiratory diseases ( 18 , 19 ). Additionally, environmental exposures, including prenatal exposure to metals, organochlorine pesticides, and other persistent organic pollutants (POPs), have been reported to be associated with adverse birth outcomes ( 4 , 20 , 21 ), including PTB, low birth weight (LBW), SGA, and other birth anthropometric features (BW, HC, and BL). Therefore, clarifying the relationship of environmental exposures, especially exposures to persistent compounds, with birth outcomes is a task of considerable significance to public health ( 3 , 13 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Gui

Chen

et al. 2022

Front. Public Health

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BackgroundA large body of emerging evidence suggests that per- and polyfluoroalkyl substances (PFAS) affect birth outcomes in various pathways, but the evidence is inconsistent. Therefore, this study aimed to systematically review the epidemiological evidence on PFAS exposure and birth outcomes.MethodsThree electronic databases were searched for epidemiological studies through February 13, 2021. We used random-effects meta-analysis for eight birth outcome indicators to calculate summary effect estimates for various exposure types. The risk of bias and the overall quality and level of evidence for each exposure-outcome pair were assessed.ResultsThe initial search identified 58 potentially eligible studies, of which 46 were ultimately included. Many PFAS were found to have previously unrecognized statistically significant associations with birth outcomes. Specifically, birth weight (BW) was associated with PFAS, with effect sizes ranging from −181.209 g (95% confidence interval (CI) = −360.620 to −1.798) per 1 ng/ml increase in perfluoroheptanesulfonate (PFHpS) to −24.252 g (95% CI = −38.574 to −9.930) per 1 ln (ng/ml) increase in perfluorodecaoic acid (PFDA). Similar patterns were observed between other PFAS and birth outcomes: perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with birth length (BL) and ponderal index (PI), PFOS and perfluorododecanoic acid (PFDoDA) with head circumference (HC), PFHpS with gestational age (GA), and perfluorononanoic acid (PFNA) and PFHpS with preterm birth (PTB). Additionally, PFDA showed a statistically significant association with small for gestational age (SGA). The level of the combined evidence for each exposure-outcome pair was considered to be “moderate”.ConclusionThis study showed that PFAS exposure was significantly associated with increased risks of various adverse birth outcomes and that different birth outcome indicators had different degrees of sensitivity to PFAS. Further studies are needed to confirm our results by expanding the sample size, clarifying the effects of different types or doses of PFAS and the time of blood collection on birth outcomes, and fully considering the possible confounders.

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Section: Introductionmentioning

confidence: 99%

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Gui

Chen

et al. 2022

Front. Public Health

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“…From observational studies, there is strong evidence that TDCs are disturbing the thyroid hormone metabolism (s. Table 2 ). This is reported for several classes of TDCs, for mother-child pairs, in case controls, smaller cohorts or larger epidemiological studies [ 6 , 102 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 18...…”

Section: Resultsmentioning

confidence: 69%

“…Some of the TDCs’ effects on TH metabolism are well characterized and summarized in Table 2 [ 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 ].…”

Section: Resultsmentioning

confidence: 99%

Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review

Großklaus

Liesenkötter

Doubek³

et al. 2023

Nutrients

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This scoping review critically discusses the publications of the last 30 years on the impact of mild to moderate iodine deficiency and the additional impact of endocrine disrupters during pregnancy on embryonal/fetal brain development. An asymptomatic mild to moderate iodine deficiency and/or isolated maternal hypothyroxinemia might affect the development of the embryonal/fetal brain. There is sufficient evidence underlining the importance of an adequate iodine supply for all women of childbearing age in order to prevent negative mental and social consequences for their children. An additional threat to the thyroid hormone system is the ubiquitous exposure to endocrine disrupters, which might exacerbate the effects of iodine deficiency in pregnant women on the neurocognitive development of their offspring. Ensuring adequate iodine intake is therefore essential not only for healthy fetal and neonatal development in general, but it might also extenuate the effects of endocrine disruptors. Individual iodine supplementation of women of childbearing age living in areas with mild to moderate iodine deficiency is mandatory as long as worldwide universal salt iodization does not guarantee an adequate iodine supply. There is an urgent need for detailed strategies to identify and reduce exposure to endocrine disrupters according to the “precautional principle”.

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“…Exposure to POPs through a mother's breast milk may develop long-term damages to the infant, such the growth and development (29), irreversible changes in the nervous system (30), increased risk of ADHD (31) and disrupted thyroid homeostasis (32). Prenatal exposure to POPs may cause higher birth weight (33), obesity during childhood (34), and adverse effects on neurodevelopment (35).…”

Section: Introductionmentioning

confidence: 99%

Determinants of Persistent Organic Pollutants (POPs) Levels in Human Specimens: A Review

Zahira

Lestari

Aris

2021

JKL

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Introduction: Numerous studies have been conducted regarding persistent organic pollutants (POPs) concentrations in human biological matrices such as blood, breast milk, urine, and hair that cause adverse health effects such as breast cancer, cardiovascular diseases, and type 2 diabetes. This study aimed to determine the POPs presence in human specimens in household settings. Discussion: A total of 28 articles were included in this study with the criteria published in 2016- 2021, original research articles, free full text available, and studied at least one of the confounding variables of POPs levels in human specimens. The narrative method was selected to synthesize this study. Grouping articles with similar results was carried out to respond to research questions. This study discovered that age, dietary habits, BMI, sex, race/ethnicity, smoking status, physical activities, residency, household dust, and industry emissions were associated with POPs levels in human specimens. Conclusion: This study concluded that each determinant could not affect the POPs levels in the human specimens on its own since those determinants are influenced by each other. Future research using systematic literature review and meta-analysis is therefore strongly advised.

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Association between prenatal exposure to persistent organic pollutants and neurodevelopment in early life: A mother-child cohort (Shanghai, China)

Cited by 17 publications

References 48 publications

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis

Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review

Determinants of Persistent Organic Pollutants (POPs) Levels in Human Specimens: A Review

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