Association between prenatal exposure to bisphenol a and birth outcomes

Abstract

Background: Previous studies investigated the relation of prenatal exposure to bisphenol A (BPA) and birth outcomes, but these results were inconsistent. The aim of this study was to investigate the relation of prenatal exposure to BPA and birth outcomes, provide comprehensive results based on current studies. Methods: The PubMed, Cochrane databases, and Web of Science databases were searched systematically by two researchers respectively from their inceptions to Oct. 2018, using the following keywords “bisphenol A, birth weight, birth length, head circumference, gestational age, birth outcomes”. We extracted β coefficient and 95% confidence interval (CI) or β coefficient and standard deviation (SD) from included study. The subgroup analysis was performed to evaluate the potential heterogeneity between studies. We conducted sensitivity analysis by excluding the each individual study to assess the results whether were stable. Finally, the publication bias was performed by accumulative forest plot. Results: Seven studies with 3004 participants met the inclusion criteria. BPA had significant positively association with birth weight (β = 21.92, 95%CI: 1.50–42.35, P = .04). No significant associations were found between BPA and birth length, head circumference and gestational age (All of P > .05). Conclusion: This meta-analysis demonstrated that the BPA was positively associated with birth weight. Therefore, further studies are needed to investigate the critical sensitive period of influencing fetal development and to investigate the difference on gender.

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

“…These results have to be interpreted with caution, since the association of BPA with fetal head circumference was no longer significant after multiple testing correction. Two previous meta-analyses reported no association between fetal exposure to BPA and gestational age at birth [7,8]. Similarly, in our study, maternal pregnancy-averaged and trimester-specific bisphenol concentrations were not associated with the risk of preterm birth or with gestational age at birth.…”

“…Of the three meta-analyses concerning BPA and birth outcomes, two reported no consistent associations of fetal exposure to BPA with weight, length or head circumference at birth, while one reported positive associations with birth weight [6][7][8]. Two studies evaluated maternal BPA urine concentrations during pregnancy with repeated measures of fetal growth.…”

“…It has been suggested that exposure to bisphenols in pregnancy may adversely affect placental development and function and subsequently lead to suboptimal fetal growth and adverse birth outcomes [4,5]. However, two meta-analyses of published studies reported no associations of fetal exposure to bisphenol A (BPA) with weight, length or head circumference at birth, while another reported positive associations with birth weight [6][7][8]. Two of these reported no association between fetal exposure to BPA and gestational age at birth [7,8].…”

“…However, two meta-analyses of published studies reported no associations of fetal exposure to bisphenol A (BPA) with weight, length or head circumference at birth, while another reported positive associations with birth weight [6][7][8]. Two of these reported no association between fetal exposure to BPA and gestational age at birth [7,8]. A few studies assessing the associations of bisphenol exposure with fetal ultrasound measurements showed inconsistent results [9][10][11][12].…”

Bisphenol A and Type 2 Diabetes Mellitus: A Review of Epidemiologic, Functional, and Early Life Factors

“…The Korean Mothers and Children’s Environmental Health (MOCEH) study revealed significant positive associations between maternal BPA exposure and higher birth weight, which were stronger in male neonates [ 97 ]. A recent meta-analysis of seven independent studies showed a similar direction of association between BPA and higher birth weight [ 98 ]. Prenatal BPA exposure has also been linked with sex-specific changes in hypothalamic–pituitary–adrenal axis function, and the epigenome-wide methylation analysis of cord blood DNA similarly identified sex-specific effects [ 99 , 100 ].…”