Association between prehospital medication and fatal outcomes in a cohort of hospitalized patients due to coronavirus disease-2019 in a referral hospital in Peru

Caira-Chuquineyra, Brenda; Fernández-Guzman, Daniel; Alvarez-Arias, Priscilla MA.; Zarate-Curi, Ángel A.; Herrera‐Añazco, Percy; Benítes-Zapata, Vicente A.

doi:10.1016/j.tmaid.2022.102472

Cited by 1 publication

(1 citation statement)

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“…Obesity, diabetes and chronic kidney disease are also independent risk factors for intubation, as well as death [ 61 ]. Other pre-existing pathological conditions, such as anemia, hypotension, dyslipidemia, hyperglycemia and use of CTS, have been reported as independent risk factors of severe COVID-19 [ 26 , 53 , 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Inflammation as Prognostic Hallmark of Clinical Outcome in Patients with SARS-CoV-2 Infection

Fuzio¹,

Inchingolo

Ruggieri³

et al. 2023

Life

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often characterized by a life-threatening interstitial pneumonia requiring hospitalization. The aim of this retrospective cohort study is to identify hallmarks of in-hospital mortality in patients affected by Coronavirus Disease 19 (COVID-19). A total of 150 patients admitted for COVID-19 from March to June 2021 to “F. Perinei” Murgia Hospital in Altamura, Italy, were divided into survivors (n = 100) and non-survivors groups (n = 50). Blood counts, inflammation-related biomarkers and lymphocyte subsets were analyzed into two groups in the first 24 h after admission and compared by Student’s t-test. A multivariable logistic analysis was performed to identify independent risk factors associated with in-hospital mortality. Total lymphocyte count and CD3+ and CD4+ CD8+ T lymphocyte subsets were significantly lower in non-survivors. Serum levels of interleukin-6 (IL-6), lactate dehydrogenase (LDH), C-reactive protein (CRP) and procalcitonin (PCT) were significantly higher in non-survivors. Age > 65 years and presence of comorbidities were identified as independent risk factors associated with in-hospital mortality, while IL-6 and LDH showed a borderline significance. According to our results, markers of inflammation and lymphocytopenia predict in-hospital mortality in COVID-19.

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