Association between Preheparin Serum Lipoprotein Lipase Mass and Acute Myocardial Infarction in Japanese Men

Abstract

A sensitive immunoassay system using a specific monoclonal antibody against lipoprotein lipase (LPL) recently demonstrated the presence of an LPL mass in preheparin serum. We reported that a preheparin serum LPL mass (pre-LPL mass) reflected the level of functioning LPL activity in the whole body and could be deeply involved in the progression of coronary atherosclerosis of stable organic angina pectoris. We examined the relation between the pre-LPL mass and acute myocardial infarction (AMI). We studied 44 males with AMI (AMI group) and 16 males with a normal coronary artery (NCA group), and measured the pre-LPL mass by enzyme-linked immunosorbent assay. Coronary risk factors including the pre-LPL mass were compared between the two groups and multiple regression analysis was performed for AMI. There were no significant differences in the lipid data, but the pre-LPL mass level was significantly low in the AMI group (52 +/- 16 vs 41 +/- 14 ng/ml, p = 0.01), and a low pre-LPL mass concentration was observed in the small sized LDL group and/or the Midband positive group. Multiple regression analysis revealed that a low pre-LPL mass and hypertriglyceridemia were independent risk factors for AMI (t value = 2.1, 2.4). The result indicates that a low pre-LPL mass may be an important risk factor for AMI and stable organic angina pectoris.

Relationship between Two AMI Risk Factors: Low Serum Lipoprotein Lipase Mass and Hypoadiponectinemia

“…Our data support previous studies 6,[10][11][12] suggesting that s-LpL and t-adiponectin occur at low levels in AMI patients. There was a significant positive correlation between s-LpL and t-adiponectin levels in AMI patients, even though no significant correlation was observed in NCA subjects.…”

“…Both t-adiponectin and s-LpL were selected as independent variables for AMI as a subordinate factor. We divided the subjects into three groups based on s-LpL and serum t-adiponectin levels (cut-off levels: s-LpL 40.0 ng/mL; t-adiponectin 4.0 g/mL) 5,6,18,19) and performed multiple logistic regression analysis for AMI as a subordinate factor (Fig. 4).…”

Serum lipoprotein lipase mass: Clinical significance of its measurement

“…Hitsumoto et al [40,41] compared pre-heparin LPL mass in men with angiographically determined coronary atherosclerosis versus that in men with normal coronary or healthy men. They found that men with coronary atherosclerosis had significantly lower pre-heparin LPL mass than did men without coronary atherosclerosis or healthy men.…”

“…They suggest that serum LPL mass is an independent determinant of incidence [40] or severity [41] of coronary artery disease even after adjustments of a number of metabolic parameters, including serum triglycerides and HDL-C.…”

Clinical Significance of Serum 7-Ketocholesterol Concentrations in the Progression of Coronary Atherosclerosis

“…Hypercholesterolemia has been established as one of the most important coronary risk factors [23][24][25][26] ; however, the average serum TC or LDL-C concentration in subjects with CAD often appears to be within the normal range in the Japanese population [27][28][29][30] . The present study also indicated that serum TC or LDL-C concentrations were not higher in CAD subjects than in NCA subjects.…”