Association between Pre-Eclampsia and Inherited Thrombophilias

Deveer, Rüya; Üstün, Yaprak Engin; Akbaba, Eren; Halisdemir, Beril; Çakar, Esra; Danışman, Nuri; Mollamahmutoğlu, Leyla; Yeşilyurt, Ahmet; Candemir, Zuhal

doi:10.3109/15513815.2012.721475

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…Reduced MTHFR enzyme activity can also alter genome instability with free radicals causing accumulation of toxins [ 14 ]. To date, numerous epidemiological studies and meta-analyses [ 9 , 20 , 21 , 22 ] confirmed that MTHFR C677T [ 10 , 17 , 23 , 24 ] and MTHFR A1298C [ 13 , 24 , 25 ] polymorphisms are associated with HDP; however, with inconsistent findings [ 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further evidence has indicated that HDP can result from epigenetic factors, as well as modifications and interactions involving genetic factors and environmental toxicants [ 29 , 30 ]. Exposure to air polluted by fine particulate matter (PM 2.5 ) [ 26 , 27 ], ozone (O 3 ), carbon monoxide (CO), nitrogen oxides (NOx), and nitrogen dioxide (NO2) [ 29 , 31 , 32 , 33 , 34 , 35 , 36 ] can trigger inflammatory reactions, increase blood coagulation, and decrease placental circulation. Consequently, these toxicants can lead to HDP [ 30 , 37 ], though the underlying mechanisms remain unclear [ 29 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide

Yang

Shiao

2018

IJERPH

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Hypertensive disorders in pregnancy (HDP) are devastating health hazards for both women and children. Both methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and air pollution can affect health status and result in increased risk of HDP for women. The major objective of this study was to investigate the effect of MTHFR polymorphisms, air pollution, and their interaction on the risk of HDP by using meta-predictive analytics. We searched various databases comprehensively to access all available studies conducted for various ethnic populations from countries worldwide, from 1997 to 2017. Seventy-one studies with 8064 cases and 13,232 controls for MTHFR C677T and 11 studies with 1425 cases and 1859 controls for MTHFR A1298C were included. MTHFR C677T homozygous TT (risk ratio (RR) = 1.28, p < 0.0001) and CT plus TT (RR = 1.07, p = 0.0002) were the risk genotypes, while wild-type CC played a protective role (RR = 0.94, p = 0.0017) for HDP. The meta-predictive analysis found that the percentage of MTHFR C677T TT plus CT (p = 0.044) and CT (p = 0.043) genotypes in the HDP case group were significantly increased with elevated levels of air pollution worldwide. Additionally, in countries with higher air pollution levels, the pregnant women with wild-type CC MTHFR 677 had a protection effect against HDP (p = 0.014), whereas, the homozygous TT of MTHFR C677T polymorphism was a risk genotype for developing HDP. Air pollution level is an environmental factor interacting with increased MTHFR C677T polymorphisms, impacting the susceptibility of HDP for women.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide

Yang

Shiao

2018

IJERPH

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“…There are conflicting results regarding thrombophilia in severe preclampsia in the literature. While a significant correlation is found between thrombophilia and severe preeclampsia [10,11,12] other pregnancy complications in some studies [13,14,15] there is not any correlation in some others [16].…”

Section: Discussionmentioning

confidence: 92%

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2016

ijhsrp

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The aim was to evaluate the relationship of recurring miscarriages and in utero mort fetus cases over 20 weeks of pregnancy (except for those caused by a systemic disease or a known pathology) with thrombophilic conditions. Our study was conducted on the patients who were admitted to our clinic with for follow ups or investigation of recurring pregnancy losses. The included patients had had at least 2 fetal losses over 8 weeks into their pregnancy or at least one loss over the 20th gestational week and gave histories of hypertensive pathologies of pregnancy such as preeclampsia or eclampsia. The control group comprised 81 patients who had at least one pregnancy without any complication or fetal loss histories. In our study, the ratios of Factor V Leiden mutation in the study group (106 cases) and the control group (81 cases) were %12 and %1.3 (p=0.01) respectively. In the patient group, the MTHFR homozygous mutation was seen 3.3 times as much and Factor V Leiden heterozygous gene mutation was determined to be seen 8.3 as much as the control group. There was a significant difference between the study and control groups in terms of Protein C and S activity (p<0.0001 ve p<0.001). In the study group, the detection rate of Protein C levels <%65 was 5.2 times more , and the Protein S activity was 12.17 times higher than the control group. Thrombophilic cases may play many roles in the pathologies which arise during pregnancies.

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“…We also used RevMan to plot funnel graphs to examine publication bias. 19 Italy 96 PE 129 Grandone (1999) 20 Italy 140 PE/GH 216 Mimuro (1998) 21 Australia 50 PE 150 Nagy (1998) 22 Hungary 69 PE 71 O'Shaughnessy (1999) 23 England 283 PE 100 Kankova (2000) 24 Czech 72 HDP 100 Rigo (2000) 25 Hungary 120 PE 101 von Tempelhoff (2000) 26 Germany 29 PE 61 Kim (2001) 27 America 250 PE 253 Livingston (2001) 28 America 110 PE 97 Agorastos (2002) 29 Greece 16 PE 100 Benedetto (2002) 30 Italy 111 PE 111 Paternoster (2002) 31 Italy 47 PE 35 Fabbro (2003) 32 Italy 52 PE 80 Schlembach (2003) 14 Germany 36 HELLP 27 Prasmusinto (2004) 33 Germany/Croatia 40 PE 72 Davalos (2005) 34 Mexico 33 PE/E 62 Gerhardt (2005) 35 German 97 PE 277 Jarvenpaa (2006) 36 Finland 82 PE 111 Ivanov (2007) 37 Bulgaria 25 PE 49 Muetze (2008) 13 German 71 HELLP 79 Best (2009) 38 America 87 PE 165 Kahn (2009) 39 Canada 113 PE 443 Dogan (2011) 40 Turkey 34 HELLP 25 Mendilcioglu (2011) 41 Turkey 29 PE 38 Dissanayake (2012) 42 Sri Lanka 175 PE 171 Karimi (2012) 16 Iran 198 PE 201 Deveer (2013) 43 Turkey 50 PE 50 Dehkordi (2014) 44 Iran 142 PE/E 142 Livrinova (2015)…”

Section: Discussionmentioning

confidence: 99%

Association of hypertensive disorders of pregnancy risk and factor V Leiden mutation: A meta‐analysis

Ruan

2019

J of Obstet and Gynaecol

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Aim To date, the conclusions of studies on a possible association between factor V Leiden (FVL, FV G1691A, rs6025) and hypertensive disorders of pregnancy (HDP) are conflicting. Here, we aimed to estimate the relationship between the risk of HDP and FVL. Methods Eligible studies focused on FVL and HDP were searched from the PubMed and the Web of Science databases up to March 31, 2018. We used random effects model for the meta‐analysis, and I2 statistic to assess the degree of heterogeneity between all included studies. To evaluate the association between FVL and the risk of HDP, we calculated the odds ratio (OR) and 95% confidence intervals (CI) comparing cases and controls of all samples and each subgroup based on different regions. Results Fifty citations on FVL and HDP were identified through the literature search, and a meta‐analysis on the GA + AA genotype between 6041 cases and 8364 controls was conducted. The holistic analysis found that pregnant women with GA or AA genotype of FVL have a 1.97‐fold (95% CI: 1.64–2.35, P < 0.00001) increased risk of HDP compared with GG carriers. While the OR are 2.23 (95% CI: 1.76–2.84, P < 0.00001) and 1.90 (95% CI: 1.12–3.23, P = 0.02) in Europe and the Middle East subgroups, respectively. Conclusion Factor V Leiden mutation is associated with an increased risk of HDP, and is particularly associated with preeclampsia and eclampsia in European women. However, further high‐quality studies are warranted to confirm the possible effectiveness of FVL in HDP patients.

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Association between Pre-Eclampsia and Inherited Thrombophilias

Abstract: The present study failed to demonstrate an association between the inherited thrombophilias and PE.

Cited by 10 publications

References 26 publications

Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide

Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide

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Association of hypertensive disorders of pregnancy risk and factor V Leiden mutation: A meta‐analysis

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