Association between Postmenopausal Osteoporosis and Experimental Periodontitis

Luo, Kai; Ma, Souzhi; Guo, Jianbin; Huang, Yongling; Yan, Fuhua; Xiao, Yin

doi:10.1155/2014/316134

Cited by 33 publications

(30 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This positive correlation is considered to have resulted from a common inflammatory mechanism of the 2 diseases by the action of prostaglandins and proinflammatory cytokines. 41 , 42 …”

Section: Discussionmentioning

confidence: 99%

Association of Lifestyle-Related Comorbidities With Periodontitis

Lee

Park

et al. 2015

Medicine

View full text Add to dashboard Cite

The aim of this study was to determine the association of periodontitis with lifestyle-related comorbidities (LCs) using data in the Korean National Health Insurance Cohort Database from 2002 to 2013.This was a retrospective study involving a large national cohort with patient samples (representing 2% of the total Korean population) stratified on the basis of sociodemographic information. Using this precisely extracted database, the correlations between LCs (cerebral infarction, angina pectoris, myocardial infarction, hypertension, diabetes mellitus, rheumatoid arthritis, erectile dysfunction, osteoporosis, and obesity) and periodontitis were investigated while adjusting for confounding bias. Univariate and multiple logistic regression analyses were used to evaluate differences in variable factors.Among a total of 1,025,340 samples, 321,103 (31.3%) cases were diagnosed with periodontitis. Statistically significant associations were found between all LCs except myocardial infarction and periodontitis (P < 0.005).Periodontitis is significantly and positively correlated with LCs (except for myocardial infarction) after adjusting for confounding bias. In particular, lifestyle-related diseases, erectile dysfunction, and osteoporosis seem to be intimately related to periodontitis.

show abstract

“…This positive correlation is considered to have resulted from a common inflammatory mechanism of the 2 diseases by the action of prostaglandins and proinflammatory cytokines. 41 , 42 …”

Section: Discussionmentioning

confidence: 99%

Association of Lifestyle-Related Comorbidities With Periodontitis

Lee

Park

et al. 2015

Medicine

View full text Add to dashboard Cite

show abstract

“…Ovariectomized rats have higher expression of IL-6, RANKL, osteoprotegerin (OPG), to a lesser extent, and downregulation of IL-10 in the periodontal tissue, suggesting the impact of estrogen hormone on inflammatory bone resorption [55•]. Hormone replacement therapy (HRT) in humans improves mandibular bone density and reduces gingival bleeding and the number of teeth lost due to periodontitis [56, 57].…”

Section: Potential Mechanisms Between Osteoporosis and Periodontitismentioning

confidence: 99%

Osteoporosis and Periodontitis

Wang

McCauley

2016

Curr Osteoporos Rep

151

124

View full text Add to dashboard Cite

Osteoporosis and periodontitis are both diseases characterized by bone resorption. Osteoporosis features systemic degenerative bone loss that leads to loss of skeletal cancellous microstructure and subsequent fracture, whereas periodontitis involves local inflammatory bone loss, following an infectious breach of the alveolar cortical bone, and it may result in tooth loss. Most cross-sectional studies have confirmed the association of osteoporosis and periodontitis primarily on radiographic measurements and to a lesser degree on clinical parameters. Multiple shared risk factors include age, genetics, hormonal change, smoking, as well as calcium and vitamin D deficiency. Both diseases could also be risk factors for each other and have a mutual impact that requires concomitant management. Suggested mechanisms underlying the linkage are disruption of the homeostasis concerning bone remodeling, hormonal balance, and inflammation resolution. A mutual interventional approach is emerging with complex treatment interactions. Prevention and management of both diseases require interdisciplinary approaches and warrants future well-controlled longitudinal and interventional studies for evidence-based clinical guidelines.

show abstract

“…However, it is difficult to find a strong body of literature in support of the relationship between osteoporosis and periodontal attachment loss or tooth loss. A report from Chinese researchers using an animal model protocol studied the association between postmenopausal osteoporosis and experimental periodontitis . Periodontitis was induced in ovariectomized rats with silk ligatures.…”

Section: Special Modifying Risk Factors: Examining Two Modelsmentioning

confidence: 99%

Tooth loss as a predictor of shortened longevity: exploring the hypothesis

Friedman¹,

Lamster²

2016

Periodontology 2000

View full text Add to dashboard Cite

Many factors contribute to human tooth loss, including oral hygiene practices, trauma, smoking, health status, socio-economic status and individual preferences. Loss of teeth impairs quality-of-life measures, including the eating of most foods that require full masticatory function. A recent study of centenarians found that at age 65-74 years, those who lived to be 100 had a lower rate of edentulism than did younger members of their birth cohort at ages 65-74 years. Oral health was consistent with compression of morbidity toward the end of life. This article explores the hypothesis that factors associated with oral disease and noncommunicable diseases may increase the risk of tooth loss and lead to diminished longevity as a result of multifactorial interactions. It specifically addresses two critical questions. The first is: 'Can we conclude that the number of teeth in aging humans can affect longevity and life expectancy?' The answer is yes. The second is: 'Is tooth loss a predictor of shortened longevity?' Again, the answer is yes. Edentulism and partial edentulism are discussed as a disability, and how the philosophy/belief systems of dental providers and patients toward retaining teeth influences the outcome of tooth loss is also examined. Osteoporosis and cognitive impairment provide examples of modifying risk factors.

show abstract

Association between Postmenopausal Osteoporosis and Experimental Periodontitis

Cited by 33 publications

References 37 publications

Association of Lifestyle-Related Comorbidities With Periodontitis

Association of Lifestyle-Related Comorbidities With Periodontitis

Osteoporosis and Periodontitis

Tooth loss as a predictor of shortened longevity: exploring the hypothesis

Contact Info

Product

Resources

About