Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach

Papadimitriou, Dimitrios T; Vassaras, Alexandros K.; Holick, Michael F.

doi:10.5501/wjv.v10.i3.111

Cited by 14 publications

(30 citation statements)

References 73 publications

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“…Moreover, the decision of the Finish authorities to fortify dietary milk products with vitamin D had led to a decrease in the number of T1DM cases [16]. From another point of view, the capacity of vitamin D to enhance the immune system might ensure a protective effect from developing severe forms of SARS-CoV-2 infection and reduce the risk of contracting the disease [17].…”

Section: Introductionmentioning

confidence: 99%

The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study

Boboc

Ilie

Ieșanu

et al. 2021

JPM

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Type 1 diabetes mellitus (T1DM) represents one of the most frequent chronic illnesses affecting children. The early diagnosis of this disease is crucial, as it plays a key role in preventing the development of a life-threatening acute complication: diabetic ketoacidosis. The etiopathogenetic role of viral infections has long been suggested and emerging data are pointing towards a complex bidirectional relationship between diabetes and COVID-19. The aim of this study is to assess the impact of the COVID-19 pandemic on the incidence and severity of new T1DM cases in children in Romania. We analyzed the differences between a group of 312 patients diagnosed with T1DM in the period 2003–2019 and a group of 147 children diagnosed during the pandemic. The data were investigated using statistical analysis of a series of relevant variables. The total number of newly diagnosed T1DM increased by 30.08% in the period March 2020–February 2021 compared to the previous years. The patients in the pandemic group had a higher mean age at the onset of T1DM, were less frequently living in an urban area, and presented a higher mean value of HbA1c. Diabetic ketoacidosis at the onset of T1DM was 67.40% more frequent, and a higher percentage of these patients presented with a severe form. The duration of T1DM symptoms did not differ significantly between the two groups. A number of 8 patients associated SARS-CoV-2 infection at the time of T1DM diagnosis.

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Section: Introductionmentioning

confidence: 99%

The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study

Boboc

Ilie

Ieșanu

et al. 2021

JPM

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“… 6 7 A geographical association between vitamin D deficiency prevalence and COVID-19 incidence and mortality has been reported. 8 Free 25(OH)D has not yet been investigated in COVID-19, but this is required to fully understand vitamin D status during acute illness and any associations with systemic inflammation. 9 Clinical trials of vitamin D supplementation in respiratory diseases have returned mixed results.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study

et al. 2021

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ObjectivesThe steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in hospitalised people with COVID-19 and influenza A and in survivors of critical illness to test the hypotheses that vitamin D insufficiency scales with illness severity and persists in survivors.DesignCross-sectional study.Setting and participantsPlasma was obtained from 295 hospitalised people with COVID-19 (International Severe Acute Respiratory and emerging Infections Consortium (ISARIC)/WHO Clinical Characterization Protocol for Severe Emerging Infections UK study), 93 with influenza A (Mechanisms of Severe Acute Influenza Consortium (MOSAIC) study, during the 2009–2010 H1N1 pandemic) and 139 survivors of non-selected critical illness (prior to the COVID-19 pandemic). Total 25(OH)D was measured by liquid chromatography-tandem mass spectrometry. Free 25(OH)D was measured by ELISA in COVID-19 samples.Outcome measuresReceipt of invasive mechanical ventilation (IMV) and in-hospital mortality.ResultsVitamin D insufficiency (total 25(OH)D 25–50 nmol/L) and deficiency (<25 nmol/L) were prevalent in COVID-19 (29.3% and 44.4%, respectively), influenza A (47.3% and 37.6%) and critical illness survivors (30.2% and 56.8%). In COVID-19 and influenza A, total 25(OH)D measured early in illness was lower in patients who received IMV (19.6 vs 31.9 nmol/L (p<0.0001) and 22.9 vs 31.1 nmol/L (p=0.0009), respectively). In COVID-19, biologically active free 25(OH)D correlated with total 25(OH)D and was lower in patients who received IMV, but was not associated with selected circulating inflammatory mediators.ConclusionsVitamin D deficiency/insufficiency was present in majority of hospitalised patients with COVID-19 or influenza A and correlated with severity and persisted in critical illness survivors at concentrations expected to disrupt bone metabolism. These findings support early supplementation trials to determine if insufficiency is causal in progression to severe disease, and investigation of longer-term bone health outcomes.

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“…We read with great interest the article entitled “Association between population vitamin D status and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) related serious-critical illness and deaths: An ecological integrative approach” recently published by Papadimitriou et al [ 1 ] in the World Journal of Virology [ 1 ]. This manuscript raised important questions and the authors performed an extensive analysis on vitamin D levels and COVID-19 incidence and severity in Europe, and the potential benefits of vitamin D supplementation to enhance the immune response to the SARS-CoV-2[ 1 ]. In the light of these results, we humbly want to state a few points for consideration.…”

Section: To the Editormentioning

confidence: 99%

“…Vitamin D deficiency is associated with poor response to respiratory infections[ 10 ], and few reports have identified vitamin D deficiency in moderate and severe COVID-19 patients with conflicting results[ 1 , 11 , 12 ].…”

Section: To the Editormentioning

confidence: 99%

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Role of vitamin D deficiency and comorbidities in COVID-19

Alberca¹,

Alberca²

2022

WJV

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Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach

Cited by 14 publications

References 73 publications

The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study

The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study

Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study

Role of vitamin D deficiency and comorbidities in COVID-19

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