Association between poor clinical prognosis and sleep duration among breast cancer patients

Mansano-Schlosser, Thalyta Cristina; Ceolim, María Filomena

doi:10.1590/1518-8345.1826.2899

Cited by 11 publications

(17 citation statements)

References 21 publications

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“…Based on the literature reviewed in this study, rather than focusing on pre-existing or pretreatment sleep disorders, almost all studies were conducted to assess the risk of all-cause death posed by sleep problems that were reported by the patients after receiving a diagnosis of breast cancer. However, given that most sleep disorders begin before a breast cancer diagnosis and precancerous sleep problems tend to linger and become aggravated during cancer treatment [6,12,31], our findings may still be deemed consistent with the findings of studies that reported sleep problems as a risk factor for breast cancer mortality [14,15,32,33]. In addition to these major findings, our study also corroborates the findings of studies that have identified age, comorbidity, hormone receptor status, menopausal status, grade of differentiation, AJCC pathologic stages, and HER2 status as independent predictors of OS (Table 2) [34][35][36][37][38].…”

Section: Discussionsupporting

confidence: 85%

“…First, a study determined that women hospitalized with breast cancer experienced more complications and were hospitalized longer if they also had a diagnosis of a sleep disorder [39]. Second, studies have indicated that sleep inconsistency and duration are associated with an increased risk of recurrence and progression in survivors of breast cancer and an increased risk of developing more aggressive breast cancer, respectively [32,33,40]. According to the consensus of the American Academy of Sleep Medicine, a sleep duration of less than 7 h is associated with abnormal immune function and an increased risk of death [41].…”

Section: Discussionmentioning

confidence: 99%

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Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer

Chen

Chiang

et al. 2022

Cancers

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PURPOSE: To investigate the effects of pre-existing sleep disorders on the survival outcomes of women receiving standard treatments for breast invasive ductal carcinoma (IDC). METHODS: We recruited patients from the Taiwan Cancer Registry Database who had received surgery for clinical stage I–III breast IDC. The Cox proportional hazards model was used to analyze all-cause mortality. We categorized the patients into those with and without sleep disorders (Groups 1 and 2, respectively) through propensity score matching. RESULTS: In the multivariate Cox regression analysis, the adjusted hazard ratio for all-cause mortality for Group 1 compared with Group 2 was 1.51 (95% confidence interval: 1.19, 1.91; p < 0.001). CONCLUSION: Our study demonstrated that the sleep disorder group had poorer survival rates than the non-sleep disorder group in breast cancer. Therefore, patients should be screened and evaluated for pre-existing sleep disorders prior to breast surgery, with such disorders serving as a predictor of survival in patients with breast cancer. Future studies may investigate the survival benefits of pharmacological and behavioral treatments for sleep problems in patients with breast cancer.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer

Chen

Chiang

et al. 2022

Cancers

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“…Several key points distinguished our study and made its strength. The objective to identify predictive factors of sleep quality in cancer patients, its impact on quality of life, and its correlation with disease prognosis was reported by several [35] 47.4% Our study: before chemotherapy 15.6% Our study: after chemotherapy 45.3% [4,6,20,21]. The correlation between quality of life and intensity of disease symptoms was previously established [20,22].…”

Section: Discussionmentioning

confidence: 74%

Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study

et al. 2020

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Background. Preservation of sleep quality is a modifiable and treatable factor, which may enhance the patient’s adherence to other supportive and palliative care procedures. The outcome of sleep disturbances in lung cancer patients before and after treatment aren’t reported. The aim of this study was to investigate changes in sleep quality before and after chemotherapy in locally advanced or metastatic NSCLC patients. Methods. It was a prospective study including 64 patients with stage III or IV nonsmall-cell lung cancer. Patients answered the Tunisian dialectal version of the following questionnaires: PSQI and QLQ-C30 in order to evaluate, respectively, the sleep quality and the quality of life. The assessments took place before chemotherapy and then repeated after the chemotherapy course was over. Results. The mean age was 62.9 years. All patients were active smokers. Before chemotherapy, there were 10 patients (15%) with poor sleep quality. The most frequent complaints were daytime sleepiness (70%) and nocturnal arousals (100%). After chemotherapy, the mean PSQI score increased from 2.9 to 5.4, and 45% of all patients had poor sleep quality. Most frequent complaints were the extension of sleep latency (69%), daytime sleepiness (98%), and nocturnal arousals (100%). Predicting factors of sleep disturbance according to statistical univariate analysis were delayed diagnosis confirmation (p=0.05), delayed treatment onset (p<10−3), depressive mood (p=0.001), and anxious mood (p=0.001). Multivariate analysis had shown a significant and independent correlation between sleep quality and shortened diagnosis and treatment delays. Sociodemographic parameters, clinical parameters, and factors related to treatment procedure had no correlation with sleep quality. Conclusions. Our study demonstrates the persistence and potential intensity worsening of sleep disturbances in advanced stage nonsmall-cell lung cancer patients. We, hereby, reported a statistical correlation between sleep quality and quality of life in our patients.

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“…15 Several studies have also reported that reduced sleep duration is associated with increased breast cancer recurrence, breast cancer-specific mortality, and all-cause mortality risks. 16,17 Randomized controlled studies have reported that patients with breast cancer who underwent cognitive behavioral therapy for insomnia demonstrated decreased depression and anxiety levels, alleviated general and clinical fatigue, and improved global quality of life. 18,19 In the current study, sleep disturbances prevalence and the related precancerous, psychosocial, and treatmentrelated factors in patients with breast cancer were assessed to identify independent predictors of sleep disturbances risks.…”

Section: Introductionmentioning

confidence: 99%

Sleep Quality and Related Factors in Patients with Breast Cancer: A Cross-Sectional Study in Taiwan

Weng¹,

Hong²,

Chen³

et al. 2021

CMAR

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Background Sleep disturbances are common and symptomatic burden in patients with breast cancer, but they are poorly documented and managed in routine clinical practice. This descriptive and cross-sectional study evaluated factors associated with post-treatment sleep disturbances in patients with breast cancer. Patients and Methods Patients with breast cancer who underwent standard treatment were enrolled and surveyed for their basic demographic data and precancerous and cancer treatment-related factors; they were also administered self-report questionnaires including the Family Adaptation, Partnership, Growth, Affection, Resolve questionnaire; Impact of Event Scale; Center for Epidemiologic Studies Depression Scale; and Maudsley Personality Inventory. Their sleep disturbances were evaluated using the Pittsburgh sleep quality index (PSQI). Independent sample t test and chi-square tests were used to compare the variables between patients with or without sleep disturbance, and multivariate logistic regression analyses were conducted to detect the independent factors. Results In total, 448 patients, including 145 with PSQI ≤ 5 and 303 with PSQI > 5, completed the investigation. Multiple logistic regression analysis revealed that significantly more patients with sleep disturbances demonstrated psychological distress, severe pain, depression, and impact of stress events than patients without sleep disturbances (adjusted odds ratios [95% confidence intervals]: 2.83 [1.135–7.067], P = 0.026; 1.14 [1.023–1.280], P = 0.018; 1.08 [1.036–1.133], P < 0.001; and 1.03 [1.002–1.051], P = 0.037, respectively). Conclusion Patients with breast cancer showed 67.6% prevalence of sleep disturbances after treatment. The patients with sleep disturbances were more likely to have previously experienced psychological disturbances, severe pain, depression within 5 years after diagnosis. After diagnosis for more than 5 years, higher distress caused by traumatic events still associated with sleep disturbances.

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Association between poor clinical prognosis and sleep duration among breast cancer patients

Abstract: Women should be encouraged to report sleep problems to nurses.

Cited by 11 publications

References 21 publications

Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer

Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer

Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study

Sleep Quality and Related Factors in Patients with Breast Cancer: A Cross-Sectional Study in Taiwan

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