Association Between Polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln Genes and Prognosis of Colorectal Cancer in a Chinese Population

Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma

“…The role of the XPD Lys751Gln polymorphism is reportedly associated with increased function of chemotherapy for various cancers, such as colorectal cancer, esophageal cancer, and non-small cell lung cancer (Gan et al, 2012;Zhang et al, 2012a;Li and Sun, 2013). Our study agreed with the results of previous studies, which provides solid evidence for the above hypothesis.…”

Correlation analysis between polymorphism of GSTP1, XPD and XRCC1 gene in esophageal carcinoma patients and treatment efficiency of cisplatin chemo-therapy

“…Similar reports can be found in a meta-analysis conducted by Gu et al [10], who showed the correlation between XRCC1 Arg399Gln polymorphism and efficacy of platinum drug in treating NonSmall Cell Lung Cancer (NSCLC). Similar observations have been found in the treatment of colon cancer [14,22] and ovarian carcinoma [23] using platinum drugs. Kim et al also found the correlation between polymorphism of Arg399Gln and GSTP1 Ile105Val locus with treatment efficacy of platinum on colorectal carcinoma [24].…”

The XPD Lys751Gln Polymorphism has Predictive Value in Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy: a Systemic Review and Meta-analysis

“…However, the opposite association was identified by two separate studies (Gan et al, 2012;Li et al, 2012), and three studies failed to provide evidence of any correlation (Martinez-Balibrea et al, 2008;Lamas et al, 2011;Kumamoto et al, 2013). Pooling the data in our analysis demonstrated that the XPD 751Gln allele showed a non-significant relationship with low objective response, and a marked association with short PFS and OS in patients overall, in Caucasians and especially in Asians in dominant model, which is consistent with the findings of the previous meta-analysis by Ming Yin et al (2011) However, subgroup analysis by ethnicity in homozygous comparison found that the Gln/ Gln genotype was significantly associated with favorable OS in Asians but with unfavorable OS in Caucasian.…”

“…The single study by Ruzzo et al (Ruzzo et al, 2007) showed substantial influence over the pooled HR for PFS in homozygous model, the exclusion of which led to loss of significance of the pooled result (HR=1.28, 95%CI: 0.89-1.84). Sensitivity analysis also demonstrated the substantial influence from the studies by Boige et al (Boige et al, 2010) and Gan et al (Gan et al, 2012) on the pooled OR in the allele and dominant model. When the two studies were excluded respectively, a statistically significant association was identified ( Figure 4).…”

“…By contrast, one article consisted of two independent studies, and studies included in this article were treated as separate studies (MartinezBalibrea et al, 2008). As a result, a total of 2286 CRC patients were enrolled in the 17 studies included in the pool analysis (Park et al, 2001;Stoehlmacher et al, 2004;Le Morvan et al, 2007;Ruzzo et al, 2007;Martinez-Balibrea et al, 2008;Pare et al, 2008;Lai et al, 2009;Boige et al, 2010;Chen et al, 2010;Etienne-Grimaldi et al, 2010;Farina Sarasqueta et al, 2011;Lamas et al, 2011;Chen et al, 2012;Gan et al, 2012;Li et al, 2012;Kumamoto et al, 2013). The selection procedure is shown in Figure 1, and the key patient characteristics are listed by study in Table 1.…”