Association between polymorphisms of cytokine genes and secretion of IL-12p70, IL-18, and IL-27 by dendritic cells in patients with pulmonary tuberculosis

Уразова, О. И.; Чурина, Е. Г.; Hasanova, R. R.; Novitsky, V. V.; Полетика, Вадим Сергеевич

doi:10.1016/j.tube.2019.02.003

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…Therefore, these promoter polymorphisms can influence the disease susceptibility by mediating the extent of the secretory response of these cytokines. 33,34 The IL-1 gene cluster contains IL-1B, IL-1A and IL-1RN which are located on chromosome 2q. The IL-1B, encoding IL-1β, is demonstrated to be 7020 base pairs in length and contains numerous polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of IL-1B rs16944 (T/C) associated with serum levels of IL-1β affects seizure susceptibility in ischemic stroke patients

Ma¹,

Sun²,

Li³

et al. 2022

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

Polymorphism of IL-1B rs16944 (T/C) associated with serum levels of IL-1β affects seizure susceptibility in ischemic stroke patients

Ma¹,

Sun²,

Li³

et al. 2022

Adv Clin Exp Med

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“…In addition, the identified genes were enriched for nearby SNPs with low p-values in TB susceptibility GWAS, indicating an association between genetic polymorphism and TB susceptibility (Blischak et al, 2017). Urazova et al analyzed the association between the secretion of the proinflammatory cytokines IL-12р70, IL-18, and IL-27 by myeloid DCs and the presence of polymorphisms in their corresponding genes in 334 TB-patient samples and found that reduced IL-18 and IL-27 secretion and the polymorphisms leading to the altered secretion of IL-12p70 were associated with Mtb dissemination (Urazova et al, 2019). TB susceptibility associated with DC migration has also been reported in human studies.…”

Section: Dcs In Genetic Susceptibility To Tb In Animal Models and Humansmentioning

confidence: 99%

Pathological and protective roles of dendritic cells in Mycobacterium tuberculosis infection: Interaction between host immune responses and pathogen evasion

Kim

Shin

2022

Front. Cell. Infect. Microbiol.

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Dendritic cells (DCs) are principal defense components that play multifactorial roles in translating innate immune responses to adaptive immunity in Mycobacterium tuberculosis (Mtb) infections. The heterogeneous nature of DC subsets follows their altered functions by interacting with other immune cells, Mtb, and its products, enhancing host defense mechanisms or facilitating pathogen evasion. Thus, a better understanding of the immune responses initiated, promoted, and amplified or inhibited by DCs in Mtb infection is an essential step in developing anti-tuberculosis (TB) control measures, such as host-directed adjunctive therapy and anti-TB vaccines. This review summarizes the recent advances in salient DC subsets, including their phenotypic classification, cytokine profiles, functional alterations according to disease stages and environments, and consequent TB outcomes. A comprehensive overview of the role of DCs from various perspectives enables a deeper understanding of TB pathogenesis and could be useful in developing DC-based vaccines and immunotherapies.

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“…Notably, human TB pleural effusions were shown to contain a specific subset of terminally differentiated IL-27-secreting CD4 + T cells with a unique expression profile of pro-inflammatory cytokines, which may perform important functions in TB immunity through the interference with pleural mesothelial cells ( 91 ). Another study, however, identified gene polymorphisms associated with a pronounced reduction of IL-27 in individuals with pulmonary TB ( 92 ).…”

Section: The Dual Impact Of Il-27 During Tbmentioning

confidence: 99%

Interleukin-27 in Tuberculosis: A Sheep in Wolf’s Clothing?

Rousseau

Hölscher

2022

Front. Immunol.

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In tuberculosis (TB), protective inflammatory immune responses and the pathological sequelae of chronic inflammation significantly depend on a timely balance of cytokine expression. In contrast to other anti-inflammatory cytokines, interleukin (IL)-27 has fundamental effects in experimental Mycobacterium tuberculosis (Mtb) infection: the absence of IL-27-mediated signalling promotes a better control of mycobacterial growth on the one hand side but also leads to a chronic hyperinflammation and immunopathology later during infection. Hence, in the context of novel host-directed therapeutic approaches and vaccination strategies for the management of TB, the timely restricted blockade of IL-27 signalling may represent an advanced treatment option. In contrast, administration of IL-27 itself may allow to treat the immunopathological consequences of chronic TB. In both cases, a better knowledge of the cell type-specific and kinetic effects of IL-27 after Mtb infection is essential. This review summarizes IL-27-mediated mechanisms affecting protection and immunopathology in TB and discusses possible therapeutic applications.

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Association between polymorphisms of cytokine genes and secretion of IL-12p70, IL-18, and IL-27 by dendritic cells in patients with pulmonary tuberculosis

Cited by 9 publications

References 20 publications

Polymorphism of IL-1B rs16944 (T/C) associated with serum levels of IL-1β affects seizure susceptibility in ischemic stroke patients

Polymorphism of IL-1B rs16944 (T/C) associated with serum levels of IL-1β affects seizure susceptibility in ischemic stroke patients

Pathological and protective roles of dendritic cells in Mycobacterium tuberculosis infection: Interaction between host immune responses and pathogen evasion

Interleukin-27 in Tuberculosis: A Sheep in Wolf’s Clothing?

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