“…The most significant risk factors of FGRS development include preeclampsia and a combination of pregnancy with extragenital pathology, accompanied by vascular damage. Various etiological factors, affecting at different stages of the development and functioning of the placenta, are ultimately involved in the general pathogenetic mechanism leading to the development of the fetal growth limit syndrome, one of the main manifestations of which is considered a violation of placental circulation -the main function of the placenta [8][9][10][11][12][13][14][15][16]. In this regard, the main direction in the study of the problem of FGLS, is the development of objective methods for prediction, preclinical diagnosis, optimal prevention and treatment, which can significantly reduce the frequency of FGLS, and its complications.…”