Association between polymorphisms in interleukins and oral lichen planus

Shi, Quan; Zhang, Tong; Huo, Na; Huang, Yang; Xu, Juan; Liu, Hongchen

doi:10.1097/md.0000000000006314

Cited by 12 publications

(14 citation statements)

References 29 publications

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“…Interestingly, some of these cytokines present altered expression in both processes approached in this work. In 2017, a meta-analysis showed that, in patients with OLP, IL-10 expression is reduced in serum and saliva [46]. IL-10 is an anti-inflammatory cytokine that can suppress bone resorption by osteoclastic suppression and regulation of bone homeostasis [47].…”

Section: Discussionmentioning

confidence: 99%

Dental Implants in Patients with Oral Lichen Planus: A Systematic Review

2020

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Background and Objectives: To integrate the available published data on patients with oral lichen planus (OLP) rehabilitated with dental implants, as well as to review the recommendations for OLP patients receiving implants. Materials and Methods: An electronic search was undertaken in February 2019 using five databases. Publications reporting cases of patients with OLP and rehabilitated with implant-supported oral prosthesis were included. Results: Twenty-two publications were included (230 patients, 615 implants). The overall implant failure rate was 13.9% (85/610). In patients with oral squamous cell carcinoma (OSCC) the failure rate was 90.6% (29/32), but none of these implants lost osseointegration; instead, the implants were removed together with the tumor. One study presented a very high implant failure rate, 76.4% (42/55), in patients with “active lichen planus”, with all implants failing between 7–16 weeks after implant placement, and its conflicting and incongruent results are discussed in detail. There was a statistically significant difference between the failure rates in implants installed in different jaws (maxilla/mandible) and when implants of different surfaces were used (turned/moderately rough), but not between patients with reticular or erosive OLP types, or between male and female patients. If OSCC patients and the cases of the latter study are not considered, then the failure rate becomes very low (2.7%, 14/523). The time between implant placement and failure was 25.4 ± 32.6 months (range 1–112). The mean ± SD follow-up was 58.9 ± 26.7 months (1–180). Conclusions: When the results of the one study with a very high failure rate and of the cases that developed OSCC are not considered, the dental implant failure rate in OLP patients was 2.7% after a follow-up of approximately five years. Recommendations are given when treating OLP patients with dental implants.

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Section: Discussionmentioning

confidence: 99%

Dental Implants in Patients with Oral Lichen Planus: A Systematic Review

2020

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“…Accordingly, Al-Mohaya and co-workers studied in 2016 the effect of gene polymorphisms of T helper cell subtype Th1 and Th2 cytokines, interferon gamma, interleukin-6, and transforming growth factor-β1, and concluded that a particular interferon gamma polymorphism (874A/T) increased the susceptibility to the disease in a Saudi cohort. The following year, Shi et al ( 2017 ) carried out a meta-analysis of the syndrome and reported an association between interleukin polymorphisms and OLP. In 2018 , Tabatabaei et al studied a single nucleotide polymorphism in codon 72 of the tumor suppressor protein P53, encoding either arginine (Arg; CGC) or proline (Pro; CCC), and concluded that the proline allele constituted a risk factor for the progression of OLP to oral squamous cell carcinoma.…”

Section: Other Possible Origins Of Oral Lichen Planusmentioning

confidence: 99%

Oral lichen planus: a microbiologist point of view

2021

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Oral lichen planus (OLP) is a chronic disease of uncertain etiology, although it is generally considered as an immune-mediated disease that affects the mucous membranes and even the skin and nails. Over the years, this disease was attributed to a variety of causes, including different types of microorganisms. This review analyzes the present state of the art of the disease, from a microbiological point of view, while considering whether or not the possibility of a microbial origin for the disease can be supported. From the evidence presented here, OLP should be considered an immunological disease, as it was initially proposed, as opposed to an illness of microbiological origin. The different microorganisms so far described as putative disease-causing agents do not fulfill Koch’s postulates; they are, actually, not the cause, but a result of the disease that provides the right circumstances for microbial colonization. This means that, at this stage, and unless new data becomes available, no microorganism can be envisaged as the causative agent of lichen planus.

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“…Among the different cytokines that are typically expressed in OLP lesions, a considerably higher level of IFN‐γ has been found in oral mucosa and serum of patients with OLP. This is suggested to be positively correlated with the progression of the disease …”

Section: Introductionmentioning

confidence: 97%

“…So far, a large number of ILs (IL-1, 2, 4, 5, 6, 8, 10, 12, and 17) have been studied in OLP hinting at a critical role of ILs in its pathogenesis and disease progression. 1,3,4,[6][7][8] The profile of some pro-inflammatory cytokines such as IFNγ, TNFα, IL-4, IL-6, and IL-8 can be elevated to various degrees in OLP patients. Among the different cytokines that are typically expressed in OLP lesions, a considerably higher level of IFNγ has been found in oral mucosa and serum of patients with OLP.…”

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confidence: 99%

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Assessment of Interleukin‐18 gene polymorphism and serum levels in oral lichen planus in an Indian population

Negi

Urs

Kumar

et al. 2019

J Oral Pathology Medicine

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Background Oral lichen planus (OLP) is a chronic, inflammatory disease with uncertain etiology. The aim of this study was to assess Interleukin‐18 (IL‐18) gene polymorphism and serum levels in OLP cases of Indian origin and to compare them with a control population of similar background. Methods The assessment of single‐nucleotide polymorphisms (SNPs) of IL‐18 gene at promoter regions −137(G/C) and −607(C/A) was done in 70 OLP cases and 70 healthy controls using sequence‐specific primer‐polymerase chain reaction (SSP‐PCR). In a subset of this cohort, comprising of 41 OLP cases and 41 controls, serum IL‐18 levels were assessed using enzyme‐linked immunosorbent assay (ELISA). Results Mean serum levels of IL‐18 among OLP cases were significantly higher when compared to controls. Genotypic and allelic frequencies of IL‐18 at position −137(G/C) showed that GG genotype and allele G was significantly higher in OLP cases, whereas, GC genotype and C allele was high in the control group. Polymorphism of IL‐18 at position −607(C/A) showed no significant differences. Conclusions Gene polymorphism at −137GG genotype and allele G seems to be associated with genetic susceptibility to OLP whereas −137GC and allele C may have a protective role against its development. However, our study lacks clear statistical correlation, the differences observed could be caused by sampling problems and the results could not be fully representative of Indian patients with OLP. Further studies are warranted to explore the role of IL‐18 genetic polymorphisms in OLP development.

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Association between polymorphisms in interleukins and oral lichen planus

Abstract: Supplemental Digital Content is available in the text

Cited by 12 publications

References 29 publications

Dental Implants in Patients with Oral Lichen Planus: A Systematic Review

Dental Implants in Patients with Oral Lichen Planus: A Systematic Review

Oral lichen planus: a microbiologist point of view

Assessment of Interleukin‐18 gene polymorphism and serum levels in oral lichen planus in an Indian population

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