Association between polymorphisms in DNA repair gene <em>XRCC1</em> and non-melanoma skin cancer risk: a meta-analysis

Abstract

ObjectiveNon-melanoma skin cancer (NMSC) is the most common malignancy with annually rising incidence. The aim of this study was to estimate the association between three coding polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) of the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) and NMSC susceptibility.MethodsOnline databases were searched to retrieve case–control studies published between January 2000 and November 2016. Pooled odds ratio (OR) and 95% confidence interval (CI) were employed to assess the strength of association. Overall, 10 relevant studies were finally included for analysis, including 3,143 NMSC patients and 3,540 controls. For each polymorphism of XRCC1 gene, there were 3,050 cases and 3,463 controls for Arg399Gln, 914 cases and 1,182 controls for Arg194Trp, and 279 cases and 413 controls for Arg280His.ResultsOur results showed that these three polymorphisms in the XRCC1 coding region were not associated with increased risk of NMSC in the total studied population. However, subgroup analysis by ethnicities demonstrated that Gln/Arg genotype of Arg399Gln polymorphism was associated with increased risk of NMSC under the heterogeneous model in Asian populations (Gln/Arg vs Arg/Arg: OR =1.39, 95% CI =1.04–1.87, P=0.03); subgroup analysis by tumor types showed that Trp/Trp genotype of Arg194Trp was positively associated with decreased cancer risk in squamous-cell skin cancer (SCC) type under the homogeneous model (Trp/Trp vs Arg/Arg: OR =0.38, 95% CI =0.16–0.92, P=0.03).ConclusionOur results suggested that Arg399Gln variant of XRCC1 gene might be a risk factor for NMSC in Asian populations, and Arg194Trp variant of XRCC1 gene might be a protective factor for patients with SCC. In addition, future case–control studies are still needed to further evaluate the effect of XRCC1 polymorphisms in NMSC risk.

Biorepositories and Biomarker Development: Regulatory Challenges

“…weak or impaired immune system is a rare but most aggressive skin cancer disease [20,21]. Interestingly, the newly discovered polyomavirus, the Merkel Cell polyomavirus was found to be associated in the pathogenesis of MCC.…”

Association of XRCC1 and XPD functional gene variants with nicotine dependence and/or schizophrenia: a case-control study and in silico analysis

“…X-ray repair cross-complementing group 1 (XRCC1) gene, found at chromosome 19q13.2, is a major component of base excision repair (BER) and is necessary for genetic stability [6]. Xeroderma pigmentosum complementation group D (XPD) is among the crucial DNA repair genes [7].…”