Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects

Zheng, Lei; Ma, Zheng; Liu, Peilin; Zhang, Guoyong; Guo, Caixia

doi:10.1080/1354750x.2023.2227361

Cited by 1 publication

(1 citation statement)

References 36 publications

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“…In addition, since biochemical biomarkers are the result of the expression of genetic biomarkers, much research has been carried out in this regard for the purpose of guidance on the diagnosis of cardiovascular diseases [51,52], drug therapy [53,54], to investigate tissue analysis and biochemical biomarkers [55][56][57], and heart-brain correlation itself [47].…”

Section: Discussionmentioning

confidence: 99%

A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

Pagano,

Corallo,

D’Aleo

et al. 2024

Biomolecules

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Background: Heart failure is an epidemiologically relevant disease because of the aging population and widespread lifestyles that promote it. In addition to the acute event, it is possible for the disease to become chronic with periodic flare-ups. It is essential to study pathology from a diagnostic and prognostic point of view and to identify parameters for effective monitoring. In addition, heart failure is associated with multiple comorbidities, including cognitive impairment, which is monitored clinically but not through specific biomarkers in these patients. The purpose of this review is to gather the most recent scientific evidence on a few possible biomarkers previously identified for monitoring heart failure and associated cognitive impairment. Methods: We surveyed studies inherent to a set of previously identified markers, evaluating English-language articles from the past five years conducted in adult heart failure patient populations. We used the databases PubMed, Web of Sciences, and Cochrane Library for search studies, and we considered articles published in journals with an impact factor greater than five in the publication year. Results: Among the biomarkers evaluated, a concordant indication for serial measurements for heart failure monitoring emerged only for interleukin-6. For the other markers, there is still little evidence available, which is interesting but sometimes conflicting. Interesting studies have also emerged for biomarkers of cognitive decline assessed in patients with heart failure, confirming the hypotheses of the increasingly studied heart-brain correlation. Conclusion: Certainly, further studies in large populations are needed to identify effective biomarkers for monitoring heart failure and associated cognitive impairment.

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