Association between polycyclic aromatic hydrocarbons and human rectal tumor or liver cancer

Levels and risk assessment of residual phthalates, polycyclic aromatic hydrocarbons and semi-volatile chlorinated organic compounds in toilet tissue papers

“…The levels of benzo[a]pyrene, B[a]P a definite carcinogen ranged between 1.94–108.71 μg/kg (Table 2). PAHs such as pyrene and benzo[a]pyrene have been linked to certain cancers in human due to their elevated levels in rectal cancer, liver cancer, gastric cancer and lung cancer tissues [[55], [56], [57]]. The elevated levels of PAHs in the toilet tissue papers may have contributed significantly to the upsurge in cancer and non-cancer incidences as reported by Bray et al [44] and WHO (2018).…”

Household Fuel Use and the Risk of Gastrointestinal Cancers: The Golestan Cohort Study

“…In another study, DNA adducts, which indicate the presence of an effective dose of genotoxic compounds, mainly PAH (Agudo et al 2012), were higher in women exposed to wood emissions than in those exposed to natural gas (Mumford et al 1993). Further, there is some evidence that suggests a possible role for PAH in the pathogenesis of GI cancers (Diggs et al 2011;Roshandel et al 2012), including studies that showed high levels of PAH biomarkers in the urine or esophageal tissues of patients with esophageal cancer (Abedi-Ardekani et al 2010;Roshandel et al 2012) and in rectal tissues of patients with rectal cancer (Jiang et al 2012). Studies that have shown higher levels of PAH-DNA adducts in patients with gastric, colorectal, and esophageal cancers (Agudo et al 2012;Diggs et al 2011;van Gijssel et al 2004) further support this hypothesis.…”

Concentrations and source identification of priority polycyclic aromatic hydrocarbons in sediment cores from south and northeast Thailand

“…Over the past few decades, many studies have examined numerous adverse health impacts related to the exposure of PAHs. Some epidemiological studies have described the potential genotoxicity of PAHs on the skin, lung, bladder, liver, and stomach ( Armstrong and Gibbs, 2009 ; Baudouin et al., 2002 ; Boada et al., 2015 ; Jiang et al., 2012 ; Kim et al., 2013 ; Sarigiannis et al., 2015 ; Xu et al., 1996 ). Carcinogenic and mutagenic potencies for various PAHs have also been extensively investigated in several environmental compartments such as aerosols, natural water, soils, and sediments ( Apiratikul et al., 2020 ; ChooChuay et al., 2020a , b , c ; Deelaman et al., 2020a , b , 2021 ; Pongpiachan, 2009 ; Pongpiachan et al., 2017 , 2018a , b ).…”