Association Between Pollution and Frailty in Older People: A Cross-Sectional Analysis of the UK Biobank

Veronese, Nicola; Maniscalco, Laura; Matranga, Domenica; Lacca, Guido; Domínguez, Ligia J.; Barbagallo, Mario

doi:10.1016/j.jamda.2022.12.027

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…The next stage of FA loss (loss of physical performance) is increased frailty. Veronese et al 6 investigated the relationship between air pollution and frailty in OP ≥ 60 years in this context. At the end of the study, the researchers concluded that exposure to NO x and other suspended PM increases the likelihood of frailty in this age group 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Veronese et al 6 investigated the relationship between air pollution and frailty in OP ≥ 60 years in this context. At the end of the study, the researchers concluded that exposure to NO x and other suspended PM increases the likelihood of frailty in this age group 6 . Frailty is the prelude to physical dependence, and this, in turn, is the stage before mortality.…”

Section: Discussionmentioning

confidence: 99%

“…It has even been shown to increase the risk of dementia 11 . In this sense, it has been evidenced that OP ≥ 60 years exposed to high levels of nitric oxide and PMs suspended in the air significantly increased their frailty levels 6 . In addition, research with European OP suggests that exposure to polluted air may negatively affect physical performance in this population 8 .…”

Section: Introductionmentioning

confidence: 99%

“…15 This environmental pollution (atmospheric and soil) represents a carcinogenic risk factor for the population, mainly due to constant and prolonged exposure to heavy metals. 15,16 As mentioned above, exposure to polluted environments decreases the quality of life of the OP, 7 increasing their fragility 6 and negatively affecting the physical performance of this population. 8 Also, women show a lower quality of life than men.…”

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confidence: 98%

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Environmental pollution and health in Chilean older adults: Impact on quality of life and functional autonomy

Huerta Ojeda,

Jofré‐Saldía,

Barahona‐Fuentes

et al. 2024

Health Science Reports

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Background and AimsDue to increased urbanization and industry, environmental pollution is a serious public health concern. Globally, the quality of life is particularly lowered by exposure to high amounts of particulate matter (PM). Chile has five industrial zones with high pollution levels, called “sacrifice zones.” However, the effect of polluted air on the quality of life and functional autonomy (FA) of older people living in industrial zones with high pollution levels is unknown. Therefore, this study aimed to determine the quality of life and FA differences between Chilean older women (OW) living in areas with lower and higher PM levels.Materials and MethodsSeventy‐two OW volunteered for this study. The sample was divided into Zone 1 (PM2.5 ≤ 15 µg/m3, n = 36) and Zone 2 (PM2.5 > 15 µg/m3, n = 36). The variables were quality of life—assessed through the SF‐36v2.0 questionnaire, and FA—assessed through the GDLAM protocols. Differences between zones were tested by Student's t‐test and Mann–Whitney test, both for independent samples (p < 0.05).ResultsAll eight dimensions of quality of life were lower in Zone 2, of which the role emotional (RE) showed significant differences between zones (p < 0.05). Performance on the GDLAM protocols and the FA index were lower in Zone 2 (p ˃ 0.05).ConclusionOW in Zone 2 showed lower quality of life and FA. PM could affect the older population's physical and mental health and, therefore, the quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 98%

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Environmental pollution and health in Chilean older adults: Impact on quality of life and functional autonomy

Huerta Ojeda,

Jofré‐Saldía,

Barahona‐Fuentes

et al. 2024

Health Science Reports

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“…Some evidence from observational studies suggests a link between air pollution and frailty. A large cross-sectional study that included 220,079 subjects aged 60 years and older demonstrated that frailty and pre-frailty were substantially correlated with exposure to air pollutants such PM 2.5 , PM 2.5-10 , or NOx (18). In addition, a Korean study also showed that PM 2.5 and PM 10 exposures were commonly associated with pre-frailty and frailty among 2,912 community-dwelling individuals aged ≥ 70 years (19).…”

Section: Introductionmentioning

confidence: 99%

Causal association between air pollution and frailty: a Mendelian randomization study

Xiao,

Huang,

Yang

et al. 2023

Front. Public Health

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BackgroundsFrailty is a significant problem for older persons since it is linked to a number of unfavorable consequences. According to observational researches, air pollution may raise the risk of frailty. We investigated the causal association between frailty and air pollution (including PM2.5, PM2.5–10, PM10, nitrogen dioxide, and nitrogen oxides) using Mendelian randomization approach.MethodsWe conducted MR analysis using extensive publically accessible GWAS (genome-wide association studies) summary data. The inverse variance weighted (IVW) method was employed as the primary analysis method. The weighted median model, MR-Egger, simple model, and weighted model approaches were chosen for quality control. The Cochran’s Q test was utilized to evaluate heterogeneity. Pleiotropy is found using the MR-Egger regression test. The MR-PRESSO method was used to recognize outliers. The leave-one-out strategy was used to conduct the sensitivity analysis.ResultsMR results suggested that PM2.5 was statistically significantly associated with frailty [odds ratio (OR) = 1.33; 95%confidence interval (CI) = 1.12–1.58, p = 0.001] in IVW method. We observed no statistical association between PM2.5–10(OR = 1.00, 95% CI = 0.79–1.28, p = 0.979), PM10(OR = 0.91, 95% CI = 0.75–1.11, p = 0.364), nitrogen dioxide (OR = 0.98, 95% CI = 0.85–1.12, p = 0.730), nitrogen oxides (OR = 1.15, 95% CI = 0.98–1.36, p = 0.086) and frailty. There was no pleiotropy in the results. The sensitivity analysis based on the leave-one-out method showed that the individual single nucleotide polymorphisms (SNPs) did not affect the robustness of the results.ConclusionThe current MR investigation shows a causal association between PM2.5 and frailty. Frailty’s detrimental progression may be slowed down with the help of air pollution prevention and control.

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Social Determinants of Physical Frailty

Buta,

Twardzik,

Samuel

et al. 2024

Frailty

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Association Between Pollution and Frailty in Older People: A Cross-Sectional Analysis of the UK Biobank

Cited by 13 publications

References 38 publications

Environmental pollution and health in Chilean older adults: Impact on quality of life and functional autonomy

Environmental pollution and health in Chilean older adults: Impact on quality of life and functional autonomy

Causal association between air pollution and frailty: a Mendelian randomization study

Social Determinants of Physical Frailty

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