Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women

Yokoi, Kohei; Egger, Norman G.; Ramanujam, V. M. Sadagopa; Alcock, Nancy W.; Dayal, Hari H.; Penland, James G.; Sandstead, Harold H.

doi:10.1152/ajpendo.00533.2002

Cited by 40 publications

(31 citation statements)

References 56 publications

(60 reference statements)

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“…The conclusions are also given credence by the relatively large sample size compared to those that have been typically employed in many other previous sensory taste studies using clinical samples (n ¼ 5-50) (Stoll and Oepen, 1994;Ripamonti et al, 1998;Yokoi et al, 2003;Matson et al, 2003;Heckmann et al, 2005). It is, however, possible that differences between the samples recruited at the different centres in terms of education and social class may have confounded the findings.…”

Section: Discussionsupporting

confidence: 53%

“…It is, however, difficult to draw conclusions from previous studies that have looked at zinc status in relation to taste acuity given that most have used zinc-depleted animal models (Liu et al, 1991;Komai et al, 2000;Goto et al, 2001) or clinical patient groups (Ripamonti et al, 1998;Yokoi et al, 2003;Kenway et al, 2004;Heckmann et al, 2005). These findings affirm those of previous animal and clinical studies in implying that salt taste sensitivity is most susceptible to zinc deficiency.…”

Section: Discussionmentioning

confidence: 70%

“…Zinc may be important in taste perception. It is present in saliva (Watanabe et al, 2005) as well as in the salivary gland (Tanaka, 2002) and appears to be linked to gustatory nerve activity (Yokoi et al, 2003). Taste impairment as a result of drug therapy or disease has been observed in cases of zinc deficiency (Kettaneh et al, 2002;Tomita & Yoshikawa, 2002), while supplemental zinc has been shown to ameliorate taste disorder in certain zinc-depleted patient groups (Stoll & Oepen, 1994;Takeda et al, 2004;Heckmann et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Zinc status and taste acuity in older Europeans: the ZENITH study

Stewart-Knox

Simpson²,

Parr

et al. 2005

Eur J Clin Nutr

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Background: Age-related decline in taste acuity may be both a cause and an effect of depleted zinc and/or increased zinc requirement. Objective: The aim of this study was to explore associations between zinc status and taste acuity in healthy older European adults aged 55-90 y. Sample: Volunteers were recruited within Italy (n ¼ 108 aged 70-90 y), the United Kingdom (UK) (n ¼ 93 aged 55-70) and two regions of France (n ¼ 186), Grenoble (aged 70-90 y) and Clermont-Ferrand (aged 55-70 y). Methods: A signal detection theory approach was adopted, employing a three-alternative, forced-choice procedure. The data were converted to R-indices and bivariate correlations were computed to explore relationships between serum zinc, erythrocyte zinc and taste acuity. ANOVA was undertaken to determine regional differences in zinc status. Results: Higher erythrocyte zinc status was associated with better acuity for salt (sodium chloride) taste in the sample as a whole (P ¼ 0.012) (n ¼ 385). Higher serum zinc levels were associated with greater sensitivity to sour taste (citric acid) (P ¼ 0.015) only in the older groups (aged 70-90 y). There were no apparent associations between serum or erythrocyte zinc status and acuity for bitter (quinine) or sweet (sucrose) tastes irrespective of age. Conclusion: These results agree with those previously suggesting that age-related detriment in sensitivity for salt taste may be associated with depleted zinc.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

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Zinc status and taste acuity in older Europeans: the ZENITH study

Stewart-Knox

Simpson²,

Parr

et al. 2005

Eur J Clin Nutr

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“…Red meat is the richest common source of zinc while fowl and fish usually provide substantially less zinc ( Table 2). Avoidance of red meat by young women was partly responsible for their being both zinc and iron deficient [32][33][34].…”

Section: Zinc In Foodmentioning

confidence: 99%

Zinc requirements and the risks and benefits of zinc supplementation

Maret

Sandstead

2006

Journal of Trace Elements in Medicine and Biology

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907

582

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“…Both methods have previously been used to assess the impact of heavy metals on human health and disease [16][17][18].…”

Section: Abstract Ivf Heavy Metals Endocrine Disruptorsmentioning

confidence: 99%

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

Dickerson¹,

Sathyapalan

Knight

et al. 2011

J Assist Reprod Genet

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Purpose There is increasing concern that environmental chemicals have a direct effect on fertility. Heavy metals such as mercury have been shown to affect various organ systems in humans including nervous system and skin, however they could also act as endocrine disrupting chemicals adversely affecting fertility. Metals such as zinc and selenium are essential micronutrients with diverse functions that may be important for reproductive outcomes. We measured mercury, zinc and selenium levels in the hair, a reliable reflection of long term environmental exposure and dietary status, to correlate with the outcome of ovarian hyperstimulation for in vitro fertilisation (IVF) treatment. Methods We analysed the hair of 30 subfertile women for mercury, zinc and selenium using inductively coupled mass spectrometry. Each woman underwent one cycle of IVF treatment. Correlation between the levels of these trace metals and treatment outcomes was investigated.Results Thirty women were recruited with mean (±SD) age of 32.7(4.4) years and BMI of 25.4(5.0)kg/m 2 . Hair mercury concentration showed a negative correlation with oocyte yield (p<0.05,βcoefficient 0.38) and follicle number (p=0.03,β coefficient0.19) after ovarian stimulation. Zinc and selenium levels in hair correlated positively with oocyte yield after ovarian stimulation (p<0.05,β coefficient0.15) and (p=0.03,β coefficient0.21) respectively. Selenium levels in hair correlated significantly with follicle number following stimulation (p=0.04, βcoefficient0.22). There was no correlation between mercury, zinc and selenium in hair and their corresponding serum levels. Conclusion These data suggest that mercury had a deleterious effect whilst there was a positive effect for zinc and selenium in the ovarian response to gonadotrophin therapy for IVF. Hair analysis offers a novel method of investigating the impact of long-term exposure to endocrine disruptors and nutritional status on reproductive outcomes. Keywords IVF . Heavy metals . Endocrine disruptorsSubfertility affects approximately 1 in 6 couples in the developed world [1], a prevalence that is likely to increase as more women delay childbirth to a later age [2]; approximately 28% of couples investigated for subfertility have a diagnosis of 'unexplained subfertility' [3]. Current treatment largely consists of assisted reproductive techniques (ART) such as IVF or IVF-ICSI, often regardless of the underlying cause. The average success rate of 25-30% for ART in Europe remains unchanged over recent years [4], prompting the search for additional factors which may influence fertility treatments and optimise success, and the identification of adverse factors such as endocrine disrupting chemicals.Capsule Mercury concentration in hair had a deleterious effect where as zinc and selenium had a beneficial effect in ovarian response to gonadotrophin therapy for IVF.

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Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women

Cited by 40 publications

References 56 publications

Zinc status and taste acuity in older Europeans: the ZENITH study

Zinc status and taste acuity in older Europeans: the ZENITH study

Zinc requirements and the risks and benefits of zinc supplementation

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

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