Association between plasma levels of PCSK9 and the presence of coronary artery disease in Japanese

Nose, Daisuke; Shiga, Yuhei; Ueda, Yôko; Idemoto, Yoshiaki; Tashiro, Kohei; Suematsu, Yasunori; Kuwano, Takashi; Kitajima, Ken; Saku, Keijiro; Miura, Shin‐ichiro

doi:10.1007/s00380-018-1218-1

Cited by 14 publications

(9 citation statements)

References 43 publications

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“…The relationship of PCSK9, total or LDL cholesterol and Lipoprotein (a) has been demonstrated in many different populations and in large study cohorts [11, 34–37]. On the other hand, the relationship of PCSK9 levels and HDL cholesterol is less well established, and a clear involvement of PCSK9 in HDL metabolism is indeed uncertain [12, 38–42]. Interestingly, we found that the relationships of PCSK9 with LDL cholesterol was affected and, as matter of fact, obscured by statin treatment, while that with HDL cholesterol was not (Fig.…”

Section: Discussionmentioning

confidence: 99%

Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina

Caselli

Turco

Ragusa

et al. 2019

Cardiovasc Diabetol

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ObjectiveAim of this study was to evaluate the relationship of plasma PCSK9 with metabolic and inflammatory profile and coronary atherosclerotic burden in patients with suspected CAD enrolled in the EVINCI study.MethodsPCSK9 was measured in 539 patients (60.3 ± 8.6 years, 256 males) with symptoms of CAD characterized by risk factors, bio-humoral profiles, and treatment. N = 412 patients underwent coronary computed tomography angiography (CTA) to assess the presence and characteristics of coronary atherosclerosis. A CTA score, combining extent, severity, composition, and location of plaques was computed.ResultsPatients were divided according to PCSK9 quartiles: I (< 136 ng/mL), II–III (136–266 ng/mL), and IV quartile (> 266 ng/mL). Compared with patients in quartile IV, patients in quartile I had a higher prevalence of the metabolic syndrome and higher values of body mass index. LDL- and HDL-cholesterol were significantly lower in patients in the quartile I than in those in quartile IV. Coronary CTA documented normal vessels in 30% and obstructive CAD in 35% of cases without differences among PCSK9 quartiles. Compared with patients with the highest levels, patients with the lowest PCSK9 levels had a higher CTA score mainly due to higher number of mixed non-obstructive coronary plaques. At multivariable analysis including clinical, medications, and lipid variables, PCSK9 was an independent predictor of the CTA score (coefficient − 0.129, SE 0.03, P < 0.0001), together with age, male gender, statins, interleukin-6, and leptin.ConclusionIn patients with stable CAD, low PCSK9 plasma levels are associated with a particular metabolic phenotype (low HDL cholesterol, the metabolic syndrome, obesity, insulin resistance and diabetes) and diffuse non-obstructive coronary atherosclerosis.Trial registration ClinicalTrials.gov NCT00979199. Registered September 17, 2009

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Section: Discussionmentioning

confidence: 99%

Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina

Caselli

Turco

Ragusa

et al. 2019

Cardiovasc Diabetol

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“…The modi ed Gensini score is an reliable marker for assessing the severity of coronary artery disease. Some experts found that patients with severe CAD were grouped according to the modi ed Gensini score, and the results indicated that there were signi cant differences between the highly rated groups and other groups 35,36 . In our work, CHR was positively correlated with the modi ed Gensini score, suggesting that patients with relatively high CHR may have more severe coronary stenosis, and that CHR may be useful in predicting the severity of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

Luo¹,

Kou²,

Yin³

2020

Preprint

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Background: Lipid and inflammatory molecules play a key role in the development of coronary atherosclerosis. Hypersensitive C-reactive proteins are used as markers of inflammation duration, and HDL-C is used as an anti-atherosclerosis component. However, few studies have combined the two indicators to explore coronary stenosis. We suggested that Hypersensitive C-reactive proteins as a marker of inflammation persistence and HDL-C as an anti-atherosclerosis component should be integrated into a single biomarker , so as to explore the correlation of Hypersensitive C-reactive protein HDL-C ratio with the severity of coronary stenosis and to predict the severity of coronary stenosis in CAD patients.Methods: We examined 360 eligible patients who underwent coronary angiography. Based on the results of coronary angiography, patients with any major coronary arteries (the left anterior descending artery, the left circumflex artery, the left main coronary artery, the right coronary artery) whose lumen diameter reduced by more than 50% were defined as CAD + group (n = 139) .Patients with luminal stenosis but no more than 50% were defined as CAD- group (n = 41), and patients without luminal stenosis (n = 180) were regarded as control group. The relationship between various serum markers and the severity of coronary stenosis was examined by Spearman correlation analysis. Logistic regression analysis was performed to identify the influencing factors of the severity of coronary artery disease.Results: The modified Gensini score was positively correlated with Hypersensitive C-reactive protein HDL-C ratio . Multiple regression analysis showed that Hypersensitive C-reactive protein HDL-C ratio were significantly associated with CAD. Hypersensitive C-reactive protein HDL-C ratio is an independent predictor of CAD. The ROC analysis provided a cut-off value of 1.17 for Hypersensitive C-reactive protein HDL-C ratio to predict CAD with 83.9% specificity and 0.242 Yoden index, and area under the ROC curve of 0.632 (95%CI 0.571-0.694, P <0.001).At the same time, the area under the ROC curve of Neutrophil HDL-C ratio was 0.620, indicating that Hypersensitive C-reactive protein HDL-C ratio as a predictor of CAD has better diagnostic performance than Neutrophil HDL-C ratio.Conclusion: Hypersensitive C-reactive protein HDL-C ratio is not only closely related to coronary artery stenosis, but also an independent predictor of severe coronary stenosis.

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“…About 1,000 patients who were clinically suspected to have CAD and who underwent CCTA were included in the FU-CCTA Registry [11-21]. The number of significantly stenosed coronary vessels (VD, ≥ 50% coronary stenosis is diagnosed as CAD), and the Gensini score was quantified using CCTA.…”

Section: Fu-ccta Registrymentioning

confidence: 99%

“…(Table 1). Recently, we examined three Registries at Fukuoka University (FU) in Japan and identified risk factors for CVD for the primary and secondary prevention of atherosclerotic coronary artery disease (CAD): the Quantitative Coronary Angiography (FU-QCA) Registry [3-10], the Coronary Computed Tomography Angiography (FU-CCTA) Registry [11-21], and the Coronary Intravascular Ultrasound (FU-IVUS) Registry [22-27] (Table 2). Here, we review the problems that persist regarding the onset and progression of CVD independent of statin treatment based mainly on our data from these three Registries.…”

Section: Introductionmentioning

confidence: 99%

Atherosclerotic Coronary Artery Disease in Patients With Cardiometabolic Syndrome

et al. 2019

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Major risk factors for cardiovascular disease (CVD) include aging, gender, smoking, family history and cardiometabolic syndrome. The relative residual risks for CVD after statin treatment for primary and secondary prevention have been reported by several large-scale randomized clinical trials. Statin treatment appears to prevent one-third of the onset and progression of CVD, but not the remaining two-thirds. There are three major problems regarding the residual risk of CVD: 1) Insufficient reduction of low-density lipoprotein cholesterol levels; 2) Low levels of high-density lipoprotein cholesterol and elevated triglyceride; and 3) Insufficient control of other risk factors (high blood pressure, obesity, metabolic syndrome, type 2 diabetes, etc.). Thus, a multifaceted preventive approach should be needed to prevent CVD after statin treatment.

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Association between plasma levels of PCSK9 and the presence of coronary artery disease in Japanese

Cited by 14 publications

References 43 publications

Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina

Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

Atherosclerotic Coronary Artery Disease in Patients With Cardiometabolic Syndrome

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