Association between plasma levels and immunolocalization of cytokines in heart valve lesions: a possible target for treatment?

Toli, Konstantina; Paraskevas, Kosmas I.; Poulakou, Maria V.; Agrogiannis, Georgios; Kavantzas, Nikolaos; Xanthopoulos, V.; Iliopoulos, Dimitrios; Mantas, Ioannis; Papachristodoulou, A; Patsouris, Efstratios; Mikhailidis, Dimitri P.; Perrea, Despina

doi:10.1517/14728222.12.10.1209

Cited by 20 publications

(11 citation statements)

References 40 publications

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“…It has been proposed that enhanced inflammation is implicated in progression of both DM [17] and AS [18]. Recent observations made in human aortic valves from patients with AS demonstrated increased expression of CRP and showed that the amount of pro-inflammatory proteins increased with the progression of AS [19]. Increased expression of tissue factor (TF), a major initiator of blood coagulation in vivo , associated with macrophage infiltration and neovascularization has been also demonstrated within the stenotic valves [20, 21].…”

Section: Introductionmentioning

confidence: 99%

Does Diabetes Accelerate the Progression of Aortic Stenosis through Enhanced Inflammatory Response within Aortic valves?

et al. 2011

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Diabetes predisposes to aortic stenosis (AS). We aimed to investigate if diabetes affects the expression of selected coagulation proteins and inflammatory markers in AS valves. Twenty patients with severe AS and concomitant type 2 diabetes mellitus (DM) and 40 well-matched patients without DM scheduled for valve replacement were recruited. Valvular tissue factor (TF), TF pathway inhibitor (TFPI), prothrombin, C-reactive protein (CRP) expression were evaluated by immunostaining and TF, prothrombin, and CRP transcripts were analyzed by real-time PCR. DM patients had elevated plasma CRP (9.2 [0.74–51.9] mg/l vs. 4.7 [0.59–23.14] mg/l, p = 0.009) and TF (293.06 [192.32–386.12] pg/ml vs. 140 [104.17–177.76] pg/ml, p = 0.003) compared to non-DM patients. In DM group, TF−, TFPI−, and prothrombin expression within valves was not related to demographics, body mass index, and concomitant diseases, whereas increased expression related to DM was found for CRP on both protein (2.87 [0.5–9]% vs. 0.94 [0–4]%, p = 0.01) and transcript levels (1.3 ± 0.61 vs. 0.22 ± 0.43, p = 0.009). CRP-positive areas were positively correlated with mRNA TF (r = 0.84, p = 0.036). Diabetes mellitus is associated with enhanced inflammation within AS valves, measured by CRP expression, which may contribute to faster AS progression.

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Section: Introductionmentioning

confidence: 99%

Does Diabetes Accelerate the Progression of Aortic Stenosis through Enhanced Inflammatory Response within Aortic valves?

et al. 2011

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“…[17][18][19] Aortic stenosis is the product of an active inflammatory process, which shares many similarities with atherosclerosis (eg, lipoprotein accumulation). 17,20,21 The fact that aortic stenosis progresses faster in patients with hypercholesterolemia 19 supports this hypothesis. As statins are indicated both in the management of hypercholesterolemia 22,23 and atherosclerosis, 24,25 it was suggested that these agents may retard the progression of aortic stenosis.…”

Section: Carotid Artery and Heart Valve Disease: A Common Occurrence?mentioning

confidence: 87%

Carotid Artery Stenosis and Heart Valve Surgery: A Complex Scenario

Paraskevas

Mikhailidis

2011

Angiology

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Anselmi et al in this issue of Angiology report a 26.4% incidence of >50% concomitant asymptomatic carotid artery stenosis in a cohort of >1000 patients undergoing isolated heart valve surgery. 1 They suggest that combined carotid endarterectomy and heart valve surgery is a safe option to reduce postoperative stroke or transient ischemic attack (TIA) episodes in these patients. 1 Some additional comments may be of interest.

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“…[17][18][19] Furthermore, statins may reduce percentage values of macrophage area, thus further supporting the theory that these agents stabilize carotid atherosclerotic plaques via reduction of the inflammatory responses. [28][29][30][31][32][33] A limitation of our study is that we did not test whether statin use is associated with macrophage concentration of the carotid plaque. However, the number of patients does not allow such subgroup analysis in this pilot study.…”

Section: Discussionmentioning

confidence: 99%

Serum Leptin Levels in Patients Undergoing Carotid Endarterectomy: A Pilot Study

et al. 2009

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Association between plasma levels and immunolocalization of cytokines in heart valve lesions: a possible target for treatment?

Cited by 20 publications

References 40 publications

Does Diabetes Accelerate the Progression of Aortic Stenosis through Enhanced Inflammatory Response within Aortic valves?

Does Diabetes Accelerate the Progression of Aortic Stenosis through Enhanced Inflammatory Response within Aortic valves?

Carotid Artery Stenosis and Heart Valve Surgery: A Complex Scenario

Serum Leptin Levels in Patients Undergoing Carotid Endarterectomy: A Pilot Study

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