Association Between Plasma High-Molecular-Weight Adiponectin and Coronary Plaque Characteristics Assessed by Computed Tomography Angiography in Conditions of Visceral Adipose Accumulation

Kunita, Eiji; Yamamoto, Hideya; Kitagawa, Toshiro; Ohashi, Norihiko; Utsunomiya, Hiroto; Oka, Takahiro; Horiguchi, Jun; Awai, Kazuo; Kihara, Yasuki

doi:10.1253/circj.cj-11-1442

Cited by 25 publications

(21 citation statements)

References 31 publications

(21 reference statements)

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“…These associations were largely mediated by parameters related to glucose and lipid metabolism and inflammation, especially HDL-cholesterol levels [95] . In a study by Kunita et al [96] , in 394 patients referred for computed tomography angiography (CTA), levels of plasma HMW adiponectin were evaluated. In patients with obstructive CAD HMW adiponectin was significantly lower than that in patients without.…”

Section: Adiponectinmentioning

confidence: 99%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

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Obesity has become an important public health issue in Western and developing countries, with well known metabolic and cardiovascular complications. In the last decades, evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences. As a consequence of the expansion of fat depots, in obese subjects, adipose tissue cells develope a phenotypic modification, which turns into a change of the secretory output. Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling, vascular biology and, moreover, participate to the systemic inflammatory response, which characterizes obesity and metabolic syndrome. This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events. A great number of adipocytokines have been described recently, linking inflammatory mileu and vascular pathology. The understanding of these pathways is crucial not only from a pathophysiological point of view, but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets. The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. Key words: Adipocytokines; Obesity; Metabolic syndrome; Coronary artery disease; Inflammation Core tip: Our article, provide a comprehensive review of the evidence about adipose tissue and cardiovascular risk, focusing on the pathophysiological and clinical role of fat-derived mediators, the so-called adipocytokines.

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Section: Adiponectinmentioning

confidence: 99%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

View full text Add to dashboard Cite

show abstract

“…Several studies have reported that, in humans, a low serum adiponectin level is associated with the presence of lipid-rich plaques and noncalcified plaques in coronary arteries assessed using intravascular ultrasound and CTCA, respectively [22][23][24][25] . These findings suggest the potential value of measuring the adiponectin level in order to select patients who require CTCA for further risk assessment.…”

Section: Laboratory Measurementsmentioning

confidence: 99%

“…Furthermore, low adiponectin levels are associated with the presence of CAD [36][37][38] . Recent clinical studies have shown that low adiponectin levels are associated with noncalcified and mixed plaques detected on CTCA [23][24][25] . However, the use of the adiponectin level as a biomarker for predicting the development of multiple coronary plaques in combination with conventional risk factors has not been fully evaluated.…”

mentioning

confidence: 99%

Predictive Value of Adiponectin in Patients with Multivessel Coronary Atherosclerosis Detected on Computed Tomography Angiography

Matsuda

Tamura

Kishida

et al. 2013

JAT

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“…4,5 Importantly, it has been known that APN is downregulated in a variety of clinical conditions or critical illnesses, such as obesity, type 2 diabetes, and coronary artery disease. 6 In addition, hepatocyte growth factor (HGF), another known anti-inflammatory adipokine, was reported to induce immune tolerance and functional recovery by use of an in vivo transfection technique in experimental autoimmune myocarditis (EAM). 7, 8 However, no clinically relevant method for the efficient delivery of APN or HGF into the heart has been well established for treating fulminant myocarditis.…”

Section: Characterization Of Svfcs and Iacs In Vitromentioning

confidence: 99%