Association between plasma glucose and glycoproteins in alcoholic smokers compared to alcoholics and teetotalers

Kavitha, G; Reddy, Vaddi Damodara; Padmavathi, P.; Nallanchakravarthula, Varadacharyulu

doi:10.1016/j.dsx.2010.05.019

Cited by 3 publications

(1 citation statement)

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“…According to previous meta-analysis studies, light-to-moderate alcohol consumption was shown to be inversely associated with the incidence of type 2 diabetes [3,4,5]. Global health reports reveal that diabetes stands in second position and alcohol in the third position on the global scale of total deaths [6,7].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and biophysical changes in plasma and erythrocyte membranes of alcohol consuming type 2 diabetics: A clinical study

Naresh

Hebbani²,

Reddy³

et al. 2021

Preprint

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Background and aims: Effects of alcohol consumption on blood glucose levels is unpredictable and more so with a known type 2 diabetic. Since type 2 diabetes is a chronic condition with impairment of glucose metabolism, influence of excess alcohol consumption in such a derailed metabolism is ought to be investigated. Our aim was to understand the interpolating relationship between the metabolisms of glucose and alcohol, by investigating the biochemical and biophysical changes in plasma and erythrocytes respectively. Methods We performed a clinical study with 20 human subjects wherein non-alcoholics, non-diabetics were considered as controls and the test subjects were categorized as alcoholics, diabetics and alcoholic diabetics. Findings were analysed against the control group. Results Increased plasma AST, ALT, ALP, and LDH enzyme activity; higher levels of nitric oxide, thiobarbituric acid reactive species (TBARS) both in plasma and erythrocyte lysate; higher fasting and postprandial glucose, glycated haemoglobin levels (Hb1Ac) levels; elevated levels of erythrocyte membrane total cholesterol / phospholipids (C/P) ratio and altered erythrocyte membrane fluidity in the alcoholic diabetics was noted. Conclusion Alcohol induced oxidative and nitrosative stress during its metabolism and its worsening effects in type II diabetics leading to a failure in the overall metabolic homeostasis is evident from the study.

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Section: Introductionmentioning

confidence: 99%