Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma

Lü, Yan; Huang, Guoliang; Pu, Xing Xiang; He, Yu; Li, Bin Bin; Liu, Xing Yan; Dong, Zigang; He, Zhiwei

doi:10.1007/s11033-012-2454-6

Cited by 18 publications

(21 citation statements)

References 29 publications

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“…Findings of an Italian study showed that the -667T>C SNP over-represented the T allele in the hepatocellular carcinoma cases (17). Recently, Lu et al (21) showed that the PIN1 promoter (-667T>C) polymorphism was associated with a decreased risk of nasopharyngeal carcinoma (NPC) in Chinese populations. However, it has been indicated that the variant -667C allele was not associated with risk of cancer (16,(18)(19)(20)22).…”

Section: Discussionmentioning

confidence: 99%

Lack of association between the PIN1 promoter −667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta-analysis

et al. 2014

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Abstract. Peptidyl-prolylcis-trans isomerase NIMAinteracting 1 (PIN1) is a critical catalyst involved in multiple oncogenic signaling pathways. The PIN1 promoter -667T>C (rs2233679) polymorphism plays a role in cancer risk. The association between PIN1 (-667T>C) polymorphism and cancer risk has been previously investigated. However, the available results are inconclusive. To derive a more precise estimation, a meta-analysis of seven published case-control studies including 4,524 cases with different tumor types and 4,561 controls was performed. Published literature from PubMed and EMBASE was retrieved. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Overall, the results did not suggest any associations between the PIN1 promoter (-667T>C) polymorphism and cancer susceptibility (OR=1.04, 95% CI: 0.91-1.18 for CC vs. TT; OR=0.98, 95% CI: 0.89-1.09 for TC vs. TT; OR=1.00, 95% CI: 0.91-1.10 for TC/CC vs. TT; OR=1.07, 95% CI: 0.97-1.18 for CC vs. TC/TT). Further stratified analysis by cancer type, ethnicity and sample size did not reveal any significant associations in the genetic models. The results of the present study demonstrate that the PIN1 promoter (-667T>C; rs2233679) polymorphism is not associated with cancer susceptibility.

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Section: Discussionmentioning

confidence: 99%

Lack of association between the PIN1 promoter −667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta-analysis

et al. 2014

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“…We reviewed the titles, abstracts and the full texts of all retrieved articles through defined criteria. Finally, 9 studies including a total of 5427 cancer cases and 5469 controls were selected in our meta-analysis (Segat et al, 2007;Lu et al, 2009;Zhao, 2009;Han et al, 2010;Lu et al, 2011;Naidu et al, 2011;Cao, 2012;Lu et al, 2013;You et al, 2013) (Figure 1). The characteristics of the selected studies are listed in Table 1.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…For the -842G>C polymorphism, Han et al (2010) found that -842C variant alleles (GC+CC) were associated with decreased risk in breast cancer; Lu at al (Lu et al, 2013) found that -842CG heterozygote but not -842CC homozygote had a significantly decreased risk of nasopharyngeal carcinoma; In another two studies, -842G>C polymorphism had no influence on breast cancer (Naidu et al, 2011) and hepatocellular carcinoma risk (Segat et al, 2007). For -667C>T polymorphism, some studies found that -667T allele was associated with increased risk of nasopharyngeal carcinoma (Lu et al, 2013) and hepatocellular carcinoma (Segat et al, 2007), but others found that this polymorphism had no association with esophageal carcinoma (You et al, 2013), lung cancer , breast cancer (Han et al, 2010;Naidu et al, 2011) and squamous cell carcinoma of the head and neck (Lu et al, 2009). Therefore, it is highly necessary to perform a quantitative and systematic investigation with rigorous methods.…”

Section: Introductionmentioning

confidence: 99%

Pin1 Promoter rs2233678 and rs2233679 Polymorphisms in Cancer: A Meta-analysis

Zhu

Liu²,

Xu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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PIN1 is one member of the parvulin PPIase family. By controlling Pro-directed phosphorylation, PIN1 plays an important role in cell transformation and oncogenesis. There are many polymorphisms in the PIN1 gene, including rs2233678 and rs2233679 affecting the PIN1 promoter. Recently, a number of case-control studies were conducted to investigate the association between PIN1 gene rs2233678 and rs2233679 polymorphism and cancer risk. However, published data are still conflicting. In this paper, we summarized data for 5,427 cancer cases and 5,469 controls from 9 studies and attempted to assess the susceptibility of PIN1 gene polymorphism to cancers by a synthetic meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the relationship. All analyses were performed using Stata software. Our results suggested that rs2233678 represented a protective factor in overall analysis (

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“…Several studies have revealed the relationship between the PIN1 gene polymorphisms, rs2233678, rs2233679, and rs2233682, and the susceptibility of cancers, such as esophageal carcinoma, nasopharyngeal carcinoma, lung cancer, breast cancer, and squamous cell carcinoma of the head and neck (SCCHN), in various races [22][23][24][25][26]. However, to date, only one study has investigated the influence that PIN1 gene polymorphisms have on the risk of HCC [27].…”

Section: Introductionmentioning

confidence: 99%

PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population

Huang

Lao

et al. 2015

Tumor Biol.

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Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) plays a critical role in different signaling pathways, cell cycle progression and proliferation, and gene expression, and it has been found to overexpress in many tumor tissues. Recently, researchers have found that PIN1 gene polymorphisms may alter the function of protein and be associated with the risk of cancer. The present study analyzed three common polymorphisms in promoter regions (rs2233678 and rs2233679) and in exon2 (rs2233682) of the PIN1 gene in 254 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and 235 healthy controls in a Guangxi study population to determine whether any relationship exists between the polymorphisms and the risk of HBV-related HCC. The results revealed that the rs2233679 TT genotype was associated with increased risk of HCC with HBV infection [odds ratio (OR) = 2.04, 95 % confidence interval (95 % CI) = 1.13-3.69, p = 0.019]. This association was stronger in men than in women (OR = 2.17, 95 % CI = 1.09-4.34, p = 0.028) as well as in men 50 years of age and older (OR = 3.91, 95 % CI = 1.29-11.80, p = 0.016); moreover, for alcohol drinkers, being a carrier of the PIN1 rs2233679 CT genotype had a moderately increased risk of HCC (OR = 3.98, 95 % CI = 1.02-15.57, p = 0.047). In contrast, people carrying the rs2233682 GA genotype and A alleles were 0.23 times more likely to develop HCC (OR = 0.23, 95 % CI = 0.06-0.87, p = 0.031 and OR = 0.23, 95 % CI = 0.06-0.87, p = 0.030). No such associations were found in the PIN1 rs2233678 polymorphisms between the HBV-related HCC cases and the controls. In addition, the haplotype GCA was found to be a high protection factor for HCC with HBV infection (OR = 0.14, 95 % CI = 0.03-0.62, p = 0.003). In conclusion, this study's findings suggest that the PIN1 rs2233679 TT genotype, the rs2233682GA genotype, and A alleles might be associated with the HBV-related HCC in a Guangxi study population.

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Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma

Cited by 18 publications

References 29 publications

Lack of association between the PIN1 promoter −667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta-analysis

Lack of association between the PIN1 promoter −667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta-analysis

Pin1 Promoter rs2233678 and rs2233679 Polymorphisms in Cancer: A Meta-analysis

PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population

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