Association between Physical Exercise and Biomarkers of Oxidative Stress among Middle-Aged and Elderly Community Residents with Essential Hypertension in China

Yu, Ying; Gao, Qin; Xia, Wanning; Zhang, Lina; Hu, Zhiyuan; Wu, Xuesen; Jia, Xiaofang

doi:10.1155/2018/4135104

Cited by 23 publications

(20 citation statements)

References 51 publications

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“…Another previous study has reported that, with the increase of exercise frequency, the oxidative stress markers is improved in hypertensive individuals who participated in walking. This study has suggested that individuals with HT should engage in walking with a frequency of 4 or more days per week 57 . Thus, it is possible that the frequency of exercise in the ET program was insufficient to affect responsiveness.…”

Section: Discussionmentioning

confidence: 96%

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Combined exercise training improves blood pressure and antioxidant capacity in elderly individuals with hypertension

Ruangthai

Phoemsapthawee

2019

Journal of Exercise Science & Fitness

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Background/objectiveAlthough regular exercise plays a role in achieving healthy aging, a specific mode of exercise may be required for elderly individuals with hypertension (HT). Therefore, this study aimed to assess the effects of combined endurance and strength training (CBT) on blood pressure (BP) and antioxidant capacity in elderly individuals with HT.MethodsIn a single-blinded, randomized controlled trial, 54 older men and women aged 67 ± 5.8 years completed endurance training (ET, n = 13), strength training (ST, n = 13), combined endurance and strength training (CBT, n = 16) or served as controls (CON, n = 12). The intervention was a supervised exercise training (1-h sessions, three per week for 12 weeks), followed by a self-supervised exercise training for 12 weeks. Measurements of BP, glutathione peroxidase (GPx), total nitrite/nitrate (NOx-), malondialdehyde (MDA), and high-sensitive C-reactive protein (hs-CRP) were obtained before and after the supervised and the self-supervised periods.ResultsAfter the supervised period, systolic BP (SBP) decreased by 7.9% in the ET (p < 0.05) and 8.2% in the CBT (p < 0.01); GPx activity increased by 41.3% in the ET (p < 0.01), 19.1% in the ST (p < 0.05), and 49.2% in the CBT (p < 0.01); NOx-concentrations increased by 66.2% in the ET and 71.9% in the CBT (both p < 0.01), MDA concentrations decreased by 65.1% in the ST (p < 0.05) and 61% in the CBT (p < 0.01); hs-CRP concentrations decreased by 49.2% in only the CBT (p < 0.05). After the self-supervised period, SBP decreases by 7.5% in only the CBT (p < 0.01); NOx-concentrations increased by 68.5% in the ET and 92.4% in the CBT (both p < 0.01). However, there was no significant difference in SBP, GPx activity, NOx-, MDA and hs-CRP concentrations between the training groups.ConclusionThe hypotensive and antioxidant effects of the CBT seem to be similar to the ET after the supervised training period. However, after the self-supervised training period, the CBT program might affect better due to greater exercise adherence and attendance in elderly individuals with HT.

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Section: Discussionmentioning

confidence: 96%

“…This study has suggested that individuals with HT should engage in walking with a frequency of 4 or more days per week. 57 Thus, it is possible that the frequency of exercise in the ET program was insufficient to affect responsiveness. The decrease in MDA concentration in the ST was consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Combined exercise training improves blood pressure and antioxidant capacity in elderly individuals with hypertension

Ruangthai

Phoemsapthawee

2019

Journal of Exercise Science & Fitness

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“…A free radical is a molecule with an unpaired electron which is involved in lung damage, inflammation, reperfusion injury, cancer, cardiovascular disorders, atherosclerosis, aging and neoplastic diseases 18 They are also involved in autoimmune disorders like rheumatoid arthritis. 19 Many studies have investigated the role of antioxidant drugs and plant-derived compounds in the prevention of oxidative stress. 20 Evidence from our results, has shown that Newbouldia laevis also contains compounds with antioxidant potential.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Free Radical Scavenging Activities of Newbouldia laevis Leaf extracts

Salemcity

Nwaneri-Chidozie

Adameh

et al. 2020

FRA

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Objectives: Oxidative stress is implicated in the etiology of life-threatening disease conditions. Newbouldia laevis (NL) have been used in folk medicine for stress related conditions, however, there is paucity of reports suggesting a connection between its efficacy and a possible antioxidant property. The aim of this study was to evaluate the antioxidant properties of NL leaf extracts. Methods: The methanol extract of NL was partitioned to obtain the chloroform fraction (CFNL) and the aqueous fraction (AFNL). Following standard laboratory procedures, the parameters were measured spectrophotometrically. Results: The MFNL recorded the highest activity for DPPH (76.4%), while all extracts only showed slight hydrogen peroxide scavenging capacity. Total antioxidant capacity at uniform concentration revealed an increasing order of activity from AFNL to MENL, correlating with total phenol contents which is in the same order. Furthermore, the extracts inhibited lipid peroxidation in a concentration dependent manner, with MENL recording the highest inhibition of 19.5%. The MENL however had the highest vitamin C concentration of 165.44mg/100ml. Conclusion: The above results not only demonstrate the antioxidant properties of NL, but suggests this as one of its possible mechanism of action and indicates the presence of potent principles with potential for application in stress related ailments.

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“…On the same research line, in a large study involving 1449 subjects, SOD activity and plasma levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were determined. Results from a subpopulation of elderly subjects with hypertension showed that different types of PA induced an improvement in antioxidant activity and a reduction in MDA levels; however, these results were not always significant for all the types of PA advocated [22]. Other direct markers of inflammation are those related to the activation of the immune system, including the toll-like receptor (TLR) on white blood cells.…”

Section: Effect Of Pa On Inflammatory Markers and Oxidative Stress Mementioning

confidence: 99%

Biohumoral Indicators Influenced by Physical Activity in the Elderly

Fossati

Torre

Borrione

et al. 2020

JCM

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In the scientific landscape, there is a growing interest in defining the role of several biomolecules and humoral indicators of the aging process and in the modifications of these biomarkers induced by physical activity and exercise. The main aim of the present narrative review is to collect the available evidence on the biohumoral indicators that could be modified by physical activity (PA) in the elderly. Online databases including Pubmed, Web of science (Medline), and Scopus were searched for relevant articles published in the last five years in English. Keywords and combination of these used for the search were the following: “biological”, “indicators”, “markers”, “physical”, “activity”, and “elderly”. Thirty-four papers were analyzed for inclusion. Twenty-nine studies were included and divided into four categories: cardiovascular (CV) biomarkers, metabolic biomarkers, inflammatory markers-oxidative stress molecules, and other markers. There are many distinct biomarkers influenced by PA in the elderly, with promising results concerning the metabolic and CV indexes, as a growing number of studies demonstrate the role of PA on improving parameters related to heart function and CV risk like atherogenic lipid profile. Furthermore, it is also a verified hypothesis that PA is able to modify the inflammatory status of the subject by decreasing the levels of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). PA seems also to be able to have a direct effect on the immune system. There is a strong evidence of a positive effect of PA on the health of elderly people that could be evidenced and “quantified” by the modifications of the levels of several biohumoral indicators.

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Association between Physical Exercise and Biomarkers of Oxidative Stress among Middle-Aged and Elderly Community Residents with Essential Hypertension in China

Cited by 23 publications

References 51 publications

Combined exercise training improves blood pressure and antioxidant capacity in elderly individuals with hypertension

Combined exercise training improves blood pressure and antioxidant capacity in elderly individuals with hypertension

Antioxidant and Free Radical Scavenging Activities of Newbouldia laevis Leaf extracts

Biohumoral Indicators Influenced by Physical Activity in the Elderly

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