Association between Physical Activity and Kidney Function

Hawkins, Marquis; Sevick, Mary Ann; Richardson, Caroline R.; Fried, Linda F.; Arena, Vincent C.; Kriska, Andrea M.

doi:10.1249/mss.0b013e31820c0130

Cited by 92 publications

(59 citation statements)

References 31 publications

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“…Exercise has a beneficial influence on most disease conditions, including diabetes [12,13,14,15] and CKD [16,17,18,19,20,21,22,23]. Regular physical activity can lead to weight loss, improves blood sugar control, reduces vascular complications, increases well-being and reduces mortality in diabetic patients [12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Regular physical activity can lead to weight loss, improves blood sugar control, reduces vascular complications, increases well-being and reduces mortality in diabetic patients [12,13,14,15]. Exercise has also been reported to benefit CKD patients by preserving the estimated glomerular filtration rate (eGFR), reducing proteinuria, blood pressure and blood lipids, and improving quality of life and survival [16,17,18,19,20,21,22,23]. However, most of the previous studies of the effect of exercise in CKD were of a cross-sectional or observational nature.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Physical Activity in Chronic Kidney Disease in the Presence of Diabetes Mellitus: A Prospective Cohort Study

Wang¹,

Tsai²,

Liang³

et al. 2013

Am J Nephrol

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Background/Aims: Although the effect of exercise on health is well established, nephrologists seldom consider physical activity in the treatment of chronic kidney disease (CKD) or CKD in the presence of diabetes mellitus (DM/CKD). The aim of the present study was to analyze the benefits of leisure-time physical activity (LTPA) in DM/CKD. Methods: A total of 445,075 adult participants who underwent a medical screening program between 1996 and 2008 were prospectively recruited. Of these, 7,863 DM/CKD subjects were identified. Each participant was categorized according to LTPA level (a product of duration and intensity) as inactive, low-active or fully active. Hazard ratios (HRs) for mortality risk were calculated. Results: Fully active LTPA was associated with lower odds of DM/CKD development and lower risk of mortality among patients with DM/CKD in a dose-response relationship. The fully active and low-active DM/CKD groups had a 26% (HR 0.74, 95% CI 0.66-0.85) and 13% (HR 0.87, 95% CI 0.75-1.01) lower risk of all-cause mortality, respectively, in comparison to the inactive group. The association of exercise with mortality rate reduction was more pronounced among DM/CKD subjects (mortality rate reduction of 446.5 per 100,000 person-years) than among subjects with diabetes alone or CKD alone. Conclusion: Exercise, at the recommended level or more, is associated not only with lower odds of DM/CKD but also with a 26% lower mortality risk among DM/CKD patients. Nephrologists should encourage all DM/CKD subjects to be physically active.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Physical Activity in Chronic Kidney Disease in the Presence of Diabetes Mellitus: A Prospective Cohort Study

Wang¹,

Tsai²,

Liang³

et al. 2013

Am J Nephrol

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“…Several potential causes or mechanisms, including anemia, an increase in protein catabolism, an inflammatory state, and a decrease in protein synthesis, have been proposed to contribute to decreased physical function [21]. By contrast, relatively few studies have addressed physical function in the predialysis period among patients with CKD [22].…”

Section: Discussionmentioning

confidence: 99%

“…CKD in the early stages is often asymptomatic, and awareness is low [21]. However, it has been reported that patients with CKD have impaired health-related QOL even in the early stages.…”

Section: Discussionmentioning

confidence: 99%

Influence of Chronic Kidney Disease on Physical Function and Quality of Life in Patients after Coronary Artery Bypass Grafting

et al. 2015

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Aims: The purposes of this study were (1) to compare body composition, physical function, and quality of life (QOL) between patients after coronary artery bypass grafting (CABG) with and without chronic kidney disease (CKD) and (2) to analyze the factors associated with physical function and QOL domains in these patients. Methods: Thirty male post-CABG patients with CKD and 30 matched controls were recruited. All subjects underwent dual-energy X-ray absorptiometry for body composition evaluation. Physical function tests included the grip strength test, 30-second chair stand test (30CST), and 6-min walk test (6MWT). Physical activity and QOL were assessed using the long form of the International Physical Activity Questionnaire and the World Health Organization Quality of Life Instrument (WHOQOL)-BREF, respectively. Results: Post-CABG patients with CKD exhibited a lower arm lean mass and higher percent leg fat mass than those without CKD (p < 0.05). The patients with CKD also had lower 30CST scores, 6MWT distances, and QOL domain of social relationships scores than those without CKD after adjusting for covariates (p < 0.05). If NYHA class was considered in the model, NYHA class became the most important factor associated with 6MWT distances (β = -0.647, p < 0.001) and the QOL domains of psychological health (β = -0.285, p = 0.027) and environment (β = -0.406, p = 0.001). Conclusion: Post-CABG patients with CKD had worse body composition, physical function, and QOL than those without CKD, and this might be associated with a worse NYHA class.

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“…Conversely, an inactive lifestyle promotes vascular inflammation, insulin resistance, obesity and hypertension. [35][36][37][38][39] Data from two independent studies 21,22 have shown that physically active patients have an improved kidney function and a lower risk of kidney function decline than inactive patients. The results of our study showing lower rates of MAU and lower UAE in physically active patients compared to inactive patients are in accordance to these findings and implicate that the vasculo-protective mechanisms mediated by regular physical exercise might translate to a reduction in renal end-organ damage.…”

Section: Discussionmentioning

confidence: 99%

Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH

Pöss

Ukena

Mahfoud

et al. 2011

Eur J Prev Cardiolog

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Association between Physical Activity and Kidney Function

Abstract: When examining the association between physical activity, measured objectively with an accelerometer, and kidney function, total and light physical activities were found to be positively associated with kidney function.

Cited by 92 publications

References 31 publications

The Role of Physical Activity in Chronic Kidney Disease in the Presence of Diabetes Mellitus: A Prospective Cohort Study

The Role of Physical Activity in Chronic Kidney Disease in the Presence of Diabetes Mellitus: A Prospective Cohort Study

Influence of Chronic Kidney Disease on Physical Function and Quality of Life in Patients after Coronary Artery Bypass Grafting

Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH

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