Association between phthalate exposure and lower lung function in an urban elderly population: A repeated-measures longitudinal study

Kim, Kyoung Nam; Lee, Mee Ri; Choi, Yoon-Hyeong; Lee, Bo Eun; Hong, Yun Chul

doi:10.1016/j.envint.2018.02.004

Cited by 29 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These physical changes to the airways then lead to restrictive and/or obstructive impairments to the lung. Additional emerging evidence indicates that exposures to pesticides, phthalates, and PFCs and per- and polyfluoroalkyl substances (PFAS) may be associated with impaired lung function ( 65 , 106 , 111 ). However, the exact mechanisms through which these chemical exposures may affect lung function are unknown, though some researchers have suggested that exposures act through oxidative stress, which is associated with declining lung function and COPD ( 66 ).…”

Section: Chemical Exposuresmentioning

confidence: 99%

Environmental Factors Influencing COVID-19 Incidence and Severity

Weaver

Head

Gould

et al. 2022

Annu. Rev. Public Health

View full text Add to dashboard Cite

Emerging evidence supports a link between environmental factors—including air pollution and chemical exposures, climate, and the built environment—and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and coronavirus disease 2019 (COVID-19) susceptibility and severity. Climate, air pollution, and the built environment have long been recognized to influence viral respiratory infections, and studies have established similar associations with COVID-19 outcomes. More limited evidence links chemical exposures to COVID-19. Environmental factors were found to influence COVID-19 through four major interlinking mechanisms: increased risk of preexisting conditions associated with disease severity; immune system impairment; viral survival and transport; and behaviors that increase viral exposure. Both data and methodologic issues complicate the investigation of these relationships, including reliance on coarse COVID-19 surveillance data; gaps in mechanistic studies; and the predominance of ecological designs. We evaluate the strength of evidence for environment–COVID-19 relationships and discuss environmental actions that might simultaneously address the COVID-19 pandemic, environmental determinants of health, and health disparities. Expected final online publication date for the Annual Review of Public Health, Volume 43 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

show abstract

Section: Chemical Exposuresmentioning

confidence: 99%

Environmental Factors Influencing COVID-19 Incidence and Severity

Weaver

Head

Gould

et al. 2022

Annu. Rev. Public Health

View full text Add to dashboard Cite

show abstract

“…An inverse correlation between phthalate-metabolite levels and PEF was also reported [127,128]. In addition, the increased urinary phthalate-metabolite concentration was shown to reduce FEV 1 and FVC in adult [127], elderly [129,130] as well as in pediatric population [128,131]. Association was also shown in phthalate-metabolite level and decrease in the FEV 1 /FVC ratio [130,131].…”

Section: Computational Modeling and Micro-dosimetric Studiesmentioning

confidence: 61%

“…As such, the model would also be well suited to study the multiple stressor effects of radon and phthalates in children. Interestingly, the association between phthalate exposure and lower pulmonary function was confirmed with the measurements of forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the peak expiratory flow (PEF) [127][128][129][130][131]. An inverse correlation between phthalate-metabolite levels and PEF was also reported [127,128].…”

Section: Computational Modeling and Micro-dosimetric Studiesmentioning

confidence: 76%

Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research

Kwan

Nikezić

Roy

et al. 2020

IJERPH

View full text Add to dashboard Cite

The present paper reviews available background information for studying multiple stressor effects of radon (222Rn) and phthalates in children and provides insights on future directions. In realistic situations, living organisms are collectively subjected to many environmental stressors, with the resultant effects being referred to as multiple stressor effects. Radon is a naturally occurring radioactive gas that can lead to lung cancers. On the other hand, phthalates are semi-volatile organic compounds widely applied as plasticizers to provide flexibility to plastic in consumer products. Links of phthalates to various health effects have been reported, including allergy and asthma. In the present review, the focus on indoor contaminants was due to their higher concentrations and to the higher indoor occupancy factor, while the focus on the pediatric population was due to their inherent sensitivity and their spending more time close to the floor. Two main future directions in studying multiple stressor effects of radon and phthalates in children were proposed. The first one was on computational modeling and micro-dosimetric studies, and the second one was on biological studies. In particular, dose-response relationship and effect-specific models for combined exposures to radon and phthalates would be necessary. The ideas and methodology behind such proposed research work are also applicable to studies on multiple stressor effects of collective exposures to other significant airborne contaminants, and to population groups other than children.

show abstract

“…Additionally, some literature studies have shown that exposure to DEHP-containing products may be associated with pancreatic cancer, testicular cancer, respiratory cancer, breast cancer, pediatric hepatoblastoma, and multiple myeloma (López-Carrillo et al, 2010;Reynolds et al, 2004). However, it has been reported that phthalate exposure causes increased respiratory and allergic complaints in children (Buckley et al, 2018), decreased lung function and depression in older ages (Kim et al, 2018) and decreased liver function and cardiovascular metabolism disorders in men (Milošević et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Di (2-Ethylhexyl) Phthalate on Lipid Peroxidation and Antioxidant Levels in Rats

KAYMAK

ALTIN>

Ertekin

2022

Van Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

Kağıt, karton, kozmetik, gıda ambalajı, çocuk oyun malzemeleri, deterjan, şampuan, sabun ve boya üretimi gibi çok çeşitli sektörlerde hammadde veya yardımcı kimyasal olarak sıklıkla kullanılan fitalatlar kanserojen ve endokrin bozucu kimyasallar arasında yer almaktadır. Bu çalışmada Di (2-Etilheksil) Fitalat (DEHP) maruziyetinin, ratlardan alınan kan örneklerinde lipid peroksidasyonu ve antioksidan seviyeleri üzerine etkileri incelendi. Materyal ve Metot:Çalışma için 250-300 gr ağırlığında 40 adet dişi Wistar-Albino rat kullanıldı. Ratlar 5 gruba ayrıldı; grup 1: kontrol grubu, grup 2: pozitif kontrol (mısır yağı bazlı diyet), grup 3: 20 mg DEHP/kg canlı ağırlık (c.a.) (test edilen en düşük doz), grup 4: 100 mg DEHP kg/c.a. (orta doz), grup 5: 500 mg DEHP kg/c.a. (test edilen en yüksek doz). Çalışma süresi 14 gün olarak belirlendi. Fitalatratlara mısır yağı içerisinde gastrik gavaj yöntemiyle verildi. Çalışma sonunda alınan kan örneklerinde malondialdehit (MDA), glutatyon (GSH), seruloplazmin, C vitamini ve toplam protein düzeyleri ölçüldü. Bulgular: DEHP verilen tüm gruplarda GSH seviyeleri kontrol grubuna göre azaldı (p <0.05). En düşük GSH düzeyi 100 mg DEHP grubunda gözlendi. MDA, seruloplazmin, C vitamini ve total proteinde gözlenen değişiklikler istatistiksel olarak anlamlı değildi. Sonuç: Fitalat uygulanan gruplarda GSH, MDA, seruloplazmin, C vitamini ve total protein seviyelerinde gözlenen değişiklikler, hücrelerde oksidatif stresle ilgili hasarın oluşmuş olabileceğini göstermektedir.

show abstract

Association between phthalate exposure and lower lung function in an urban elderly population: A repeated-measures longitudinal study

Cited by 29 publications

References 41 publications

Environmental Factors Influencing COVID-19 Incidence and Severity

Environmental Factors Influencing COVID-19 Incidence and Severity

Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research

The Effect of Di (2-Ethylhexyl) Phthalate on Lipid Peroxidation and Antioxidant Levels in Rats

Contact Info

Product

Resources

About