Association between periodontitis and uric acid levels in blood and oral fluids: a systematic review and meta-analysis

Ye, Lu-wen; Zhao, Li; Mei, Zesong; Zhou, Yinghong; Takata, Yasuyuki

doi:10.1186/s12903-023-02900-8

Cited by 5 publications

(1 citation statement)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous observational studies with small sample sizes have noted elevated blood UA levels in individuals with periodontitis compared to those without [16,17]. However, these increases in blood UA levels have often fallen within the normal range, as indicated in the latest systematic review conducted by our research group [7].…”

Section: Discussionmentioning

confidence: 80%

Hyperuricemia and Elevated Uric Acid/Creatinine Ratio are Associated with a Higher Risk of Periodontitis: A Population- based Cross-Sectional Study

Chen,

Lu,

Lin

et al. 2024

Preprint

View full text Add to dashboard Cite

Objectives To explore the relationship between hyperuricemia and the risk of developing periodontitis. Materials and Methods A representative dataset of 10,158 adults was extracted from the National Health and Nutrition Examination Survey (NHANES) 2009–2014. The relationship between hyperuricemia (the primary exposure) and the risk of periodontitis (outcome) were evaluated using weighted logistic regression models. Serum uric acid (UA) levels and the UA to creatinine (UA/Cr) ratio were used as secondary exposures. Their associations with the risk of periodontitis were analyzed using weighted logistic regression or restricted cubic spline regression. Results The prevalence of moderate/severe periodontitis was 56.7% among individuals with hyperuricemia and 44.8% among those without. After adjustment, individuals with hyperuricemia had a 26.9% higher risk of developing moderate/severe periodontitis compared to those without hyperuricemia (adjusted OR = 1.269, 95% CI = 1.080 to 1.492, P = 0.006). This increased risk could be explained by a linear relationship with the serum UA/Cr ratio and a U-shaped relationship with serum UA levels. Each unit increase in the serum UA/Cr ratio was associated with a 4.6% higher risk of developing moderate/severe periodontitis (adjusted OR = 1.046, 95% CI = 1.008 to 1.086, P = 0.021). Additionally, each 1 mg/dL increase in serum UA was associated with a 10.2% higher risk (adjusted OR = 1.102, 95% CI = 1.008 to 1.206, P = 0.035) of developing moderate/severe periodontitis when UA levels were greater than 5.5 mg/dL, but a 10.6% lower risk when UA levels were 5.5 mg/dL or lower (adjusted OR = 0.894, 95% CI = 0.800 to 0.998, P = 0.046). Sensitivity analyses validated the robustness of the findings. Conclusions This study provides the first direct evidence that hyperuricemia is associated with an increased risk of developing periodontitis, especially the moderate and severe forms. Clinical Relevance Individuals with hyperuricemia may represent a subgroup of the population susceptible to periodontitis. It may be prudent to initiate timely systemic and periodontal interventions in patients with hyperuricemia to halt the progression of periodontitis.

show abstract

Section: Discussionmentioning

confidence: 80%