Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study

Abstract

Abstract. Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan-Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C-reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19-9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000-1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15-5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation.

Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation

“…We report here two distinct, though linked mechanisms activated by the oral pathobiont P. gingivalis that may possibly promote oral and other cancers: (a) immunosuppression through induction of MDDSCs, predominantly dependent on the DC-SIGN targeting Mfa1 fimbriae and (b) oncogenic response, predominantly through the CXCR4-targeting FimA fimbriae. Several recent reviews discuss the various cancers associated with CP, including gastrointestinal, pancreatobiliary tract 50 and oral squamous cell carcinoma (OSCC) 4 , 51 , 52 . OSCC represents the sixth most common malignant tumor.…”

A continuous flow PCR array microfluidic chip applied for simultaneous amplification of target genes of periodontal pathogens

“…2 Research also has demonstrated that it is also related with other diseases ( e.g. , cancer, 3 cardiovascular diseases, 4 respiratory tract infection, type 2 diabetes and neurodegenerative diseases 5 ), and thus the study of periodontal pathogens has attracted people's attention in various research fields. 6,7…”

Porphyromonas gingivalis Suppresses Trophoblast Invasion by Soluble Factors

“…Epidemiologic studies have suggested that periodontitis is a serious risk factor for other systemic disorders, including pneumonia, 4,5 diabetes mellitus, 6,7 atherosclerosis 8,9 cardiovascular disease, 10 and cancer 11,12 . Periodontitis is also regarded as a risk factor for pregnancy complications, including preterm‐birth (PTB), 13 fetal growth retardation (FGR), 14,15 and pre‐eclampsia (PE) 16 .…”