Association between periodontitis and preeclampsia in never‐smokers: a prospective study

Ha, Jung-Eun; Jun, Jin Yong; Ko, Hyunjung; Paik, Dai‐Il; Bae, Kwang‐Hak

doi:10.1111/jcpe.12281

Cited by 29 publications

(29 citation statements)

References 41 publications

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“…Xiong et al (2009) found that periodontitis was associated with GDM (77.4% of pregnant women with GDM had periodontis) with an adjusted odds ratio of 2.6 and a confidence interval of 95% in their case-control study of 53 pregnant women with GDM and 106 without GDM. Ha et al (2014) found "a significant relationship between periodontitis and preeclampsia in never smokers" (p. 869) in their prospective cohort study of 283 pregnant women who had never smoked, 67 with periodontitis and 216 without periodontitis.…”

Section: Periodontitismentioning

confidence: 95%

“…Recent studies have shown an association between periodontitis during pregnancy and low birth weight (LBW), very low birth weight (VLBW), preeclampsia, and GDM (Corbella et al, 2016;Guimarã es et al, 2012;Ha, Jun, Ko, Paik, & Bae, 2014;Xiong et al, 2009). Guimarã es et al (2012 showed in their crosssectional study of 1,206 postpartum women that "maternal periodontitis was associated with a decrease in mean birth weight, as well as LBW and VLBW" (p. 1024).…”

Section: Periodontitismentioning

confidence: 98%

See 1 more Smart Citation

Oral Health in Pregnancy

Hartnett¹,

Haber²,

Krainovich-Miller³

et al. 2016

Journal of Obstetric, Gynecologic & Neonatal Nursing

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Oral health is crucial to overall health. Because of normal physiologic changes, pregnancy is a time of particular vulnerability in terms of oral health. Pregnant women and their providers need more knowledge about the many changes that occur in the oral cavity during pregnancy. In this article we describe the importance of the recognition, prevention, and treatment of oral health problems in pregnant women. We offer educational strategies that integrate interprofessional oral health competencies.

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Section: Periodontitismentioning

confidence: 95%

Section: Periodontitismentioning

confidence: 98%

Oral Health in Pregnancy

Hartnett¹,

Haber²,

Krainovich-Miller³

et al. 2016

Journal of Obstetric, Gynecologic & Neonatal Nursing

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show abstract

“…Periodontitis is related to rheumatoid arthritis, and treatment for the former has an effect on both the latter and systemic inflammation (Payne et al, 2015). In addition, preeclampsia (Ha et al, 2014), other complications during pregnancy (Zi et al, 2015), and inflammatory bowel disease (Vavricka et al, 2013), amongst other conditions, have been shown to be associated with chronic periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of CASP gene polymorphisms in periodontal disease

Sw¹,

Kim²,

Chung³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Caspases (CASP) are intracellular proteases that play roles as mediators of apoptosis. Activation of caspase 3 is enhanced in chronic periodontitis. Thus, we hypothesized that single nucleotide polymorphisms (SNPs) of CASP genes might be associated with this condition in the Korean population. To investigate whether such polymorphisms might be involved in the development of periodontal disease, 51 patients and 33 control subjects were assessed. A total of 201 CASP gene SNPs were analyzed with genotypes being determined using and Axiom™ genomewide human assay. SNPStats and SPSS 18.0 were used for the analysis of genetic data and logistic regression models were utilized to evaluate odds ratios, 95% confidence intervals, and P values. Of the 201 SNPs, only three (rs12108497, rs4647602, and rs113420705, all in the CASP3 gene) were significantly associated with chronic periodontitis (P < 0.05). The minor allele frequencies of these SNPs were higher in the patient group than in the control group. In addition, the TC and GT haplotypes 18070 S.W. Kang et al. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18069-18077 (2015) formed by rs4647602 and rs113420705 were found to be associated with chronic this disease (TC haplotype, P = 0.0039; GT haplotype, P = 0.002). These results suggest that CASP3 gene polymorphisms may be associated with susceptibility to periodontal disease in the Korean population.

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“…In a previous study, the authors reported that Pg lipopolysaccharide suppressed trophoblastic invasion in the presence of nicotine, 33 and results are consistent with pregnancy complications that are common among smokers. However, a recent report suggested that periodontitis is an independent risk factor for PE in non‐smoking women 34 . Although early studies suggested the presence of Pg in placental tissues 35,36 and demonstrated in vitro infection in cultured trophoblasts, 37 its pathologic role is not clear.…”

mentioning

confidence: 99%

Porphyromonas gingivalis Suppresses Trophoblast Invasion by Soluble Factors

Hirohata

Komine‐Aizawa

Tamura

et al. 2017

Journal of Periodontology

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PG-sup inhibits trophoblast invasion and affects trophoblast morphology without direct cytotoxicity. These results indicate that Pg produces soluble factor(s) that suppress trophoblast invasion and subsequent vascular remodeling, which affect placental growth and fetal well-being. It is expected that the current findings will explain the increased prevalence of pregnancy complications in patients with periodontitis.

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Association between periodontitis and preeclampsia in never‐smokers: a prospective study

Abstract: There was a significant relationship between periodontitis and the occurrence of preeclampsia among never-smokers.

Cited by 29 publications

References 41 publications

Oral Health in Pregnancy

Oral Health in Pregnancy

Assessment of CASP gene polymorphisms in periodontal disease

Porphyromonas gingivalis Suppresses Trophoblast Invasion by Soluble Factors

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