Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis

Abstract

BackgroundInflammation is a common feature of both peripheral arterial disease (PAD) and periodontitis. Some studies have evaluated the association between PAD and periodontitis. However, there is still no specialized meta-analysis that has quantitatively assessed the strength of the association. Thus, we conducted this meta-analysis to critically assess the strength of the association between PAD and periodontitis.MethodsPubMed, Embase, and the Cochrane Library were searched for observational studies of the association between periodontitis and PAD in February 2018. Risk ratios (RRs) and their 95% confidence intervals (CIs) from included studies were pooled to evaluate the strength of the association between periodontitis and PAD. Weighted mean differences (WMDs) and their 95% CIs were pooled to compare the difference in periodontal-related parameters between PAD and non-PAD patients.ResultsSeven studies including a total of 4307 participants were included in the meta-analysis. The pooled analysis showed that there was a significant difference in the risk of periodontitis between PAD patients and non-PAD participants (RR = 1.70, 95% CI = 1.25–2.29, P = 0.01). There was also a significant difference in number of missing teeth between PAD patients and non-PAD participants (WMD = 3.75, 95% CI = 1.31–6.19, P = 0.003). No significant difference was found in clinical attachment loss between PAD patients and non-PAD participants (WMD = − 0.05, 95% CI = − 0.03–0.19, P = 0.686).ConclusionIn conclusion, the results of this meta-analysis revealed a significant relationship between periodontitis and PAD. Moreover, our study indicated that PAD patients had more missing teeth than control subjects did. Further high-quality and well-designed studies with specific inclusion and exclusion criteria are required to strengthen the conclusions of this study.Electronic supplementary materialThe online version of this article (10.1186/s12872-018-0879-0) contains supplementary material, which is available to authorized users.

Periodontitis and cardiovascular diseases: Consensus report

“…There is limited but consistent evidence that individuals with periodontitis have a higher prevalence and incidence of PAD compared to individuals without periodontitis (Yang et al, ). For cross‐sectional data, the most significant evidence comes from two large, population‐based studies in the United States (NHANES 1999–2002) and South Korea (KoGES‐CAVAS).…”

Periodontitis and Cardiovascular Diseases. Consensus Report

“…There is limited but consistent evidence that individuals with periodontitis have a higher prevalence and incidence of PAD compared to individuals without periodontitis [140]. For cross-sectional data, the most significant evidence comes from two large, population-based studies in the USA (NHANES 1999(NHANES -2002 and South Korea (KoGES-CAVAS).…”

Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health

“…Thus, a significant association was seen between incident tooth loss and PAD, particularly in men who had periodontal disease [221]. A recent meta-analysis by Yang et al (2018) [222] found that the risk of periodontitis has been significantly increased in patients with PAD when compared to the participants without PAD (RR: 1.70, 95% CI: 1.25–2.29, p = 0.01), implying that a significant association is there between periodontitis and PAD.…”