Association between periodontitis and chronic kidney disease by functional atherosclerosis status among older Japanese individuals: A cross‐sectional study

Abstract

Aim This study aimed to clarify the influence of functional atherosclerosis on the association between periodontitis and chronic kidney disease (CKD). Materials and Methods A cross‐sectional study of 998 older Japanese individuals aged 60–99 years who participated in an oral health check‐up was conducted. Early and advanced periodontitis were defined as periodontal pocket depth of 4.0–5.9 mm and ≥6.0 mm, respectively. Functional atherosclerosis was defined as cardio‐ankle vascular index ≥9.0. Results Of the 998 study participants, 238 (23.8%) had CKD. No significant associations between periodontitis and CKD were observed in participants without functional atherosclerosis. After adjusting for known cardiovascular risk factors, the odds ratio (OR) (95% confidence interval [CI]) was 1.31 (0.81–2.11) for early periodontitis and 0.74 (0.41–1.34) for advanced periodontitis. Significant positive associations were observed for participants with functional atherosclerosis; the adjusted ORs (95% CIs) were 1.76 (1.04–3.01) for early periodontitis and 1.95 (1.05–3.63) for advanced periodontitis. Conclusions A significant positive association between periodontitis and CKD was established for older participants with functional atherosclerosis. No significant associations were observed for those without functional atherosclerosis. These results can help clarify the influence of periodontitis on systemic circulation.

Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population

“…However, this concept has not become widespread yet. Evaluating vascular health using a combination of structural atherosclerosis and functional atherosclerosis could be efficient in daily clinical practice [74,75]. Further investigation based on this concept is necessary.…”

Sol–Gel Technologies to Obtain Advanced Bioceramics for Dental Therapeutics

“…In addition, one of the most interesting aspects currently facing dentistry is the possible connection between chronic oral inflammatory processes of infectious origin (chronic apical periodontitis and periodontal disease) and systemic health status [1,3,4]. Several epidemiological studies highlight the connection between chronic oral inflammation and systemic diseases, such as ischemic heart disease [5], hypertension [6], diabetes [7], metabolic syndrome [8], renal disease [9,10], inflammatory bowel disease [11,12], rheumatoid arthritis [13], osteoporosis [14], memory loss [15], adverse pregnancy outcomes [16], cancer [17,18], respiratory diseases [19] and COVID-19 [20].…”

Prevalence of oral infections in chronic kidney disease patients: A cross‐sectional study

“…Regarding CKD, a significant positive association between PD and CKD has been established (Deschamps‐Lenhardt et al, 2019; Nylund et al, 2018; Ruokonen et al, 2019; Shimizu et al, 2023). Moreover, PD is universally present in patients undergoing peritoneal dialysis, and the presentation of periodontitis influences their systemic inflammatory state (Chen et al, 2023).…”

“…Regarding CKD, a significant positive association between PD and CKD has been established (Deschamps-Lenhardt et al, 2019;Nylund et al, 2018;Ruokonen et al, 2019;Shimizu et al, 2023).…”