Association between periodontitis and cardiovascular health in rheumatoid arthritis patients: Prospective effect of periodontal treatment on cardiovascular risk

Salah, Shaimaa; Hammam, Nevin; Razek, Mohamed Raouf Abdel; Ismail, Nadia M.; Fikry, Ahmed Mortada; Ali, Wageeh A.; Abda, Essam A.

doi:10.1016/j.ejr.2023.05.001

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…The common pathogenetic mechanisms underlying the association between cardiovascular diseases, RA, and periodontitis are the following: alteration of cytokine levels by bacterial endotoxins, oxidative stress, cross-reaction between RA-specific autoantibodies and antibodies against Pg on cardiac cells, endothelial dysfunction, and alteration of the lipid balance [145]. Salah S. et al demonstrated that NSPT for 6 months reduced the carotid intimal medial thickness of RA patients and tends to reduce the Framingham risk score, exerting a cardiovascular protective effect [123].…”

Section: The Effect Of Non-surgical Periodontal Treatment (Nspt) On R...mentioning

confidence: 99%

The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review

Inchingolo,

Avantario

et al. 2023

IJMS

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Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that widely spread and share the same patterns of pro-inflammatory cytokines. This systematic review aims to evaluate the effects of non-surgical periodontal treatment (NSPT) on RA and, conversely, the impact of disease-modifying anti-rheumatic drugs (DMARDs) on periodontitis. PubMed, Embase, and Web of Science were searched using the MESH terms “periodontitis” and “rheumatoid arthritis” from January 2012 to September 2023. A total of 49 articles was included in the final analysis, 10 of which were randomized controlled trials. A total of 31 records concerns the effect of NSPT on parameters of RA disease activity, including a 28-joint disease activity score, anti-citrullinated protein antibodies, rheumatoid factor, C reactive protein, erythrocyte sedimentation rate, pro-inflammatory cytokines and acute phase proteins in serum, saliva, gingival crevicular fluid, and synovial fluid. A total of 18 articles investigated the effect of DMARDs on periodontal indexes and on specific cytokine levels. A quality assessment and risk-of-bias of the studies were also performed. Despite some conflicting results, there is evidence that RA patients and periodontitis patients benefit from NSPT and DMARDs, respectively. The limitations of the studies examined are the small samples and the short follow-up (usually 6 months). Further research is mandatory to evaluate if screening and treatment of periodontitis should be performed systematically in RA patients, and if the administration of DMARDs is useful in reducing the production of cytokines in the periodontium.

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Section: The Effect Of Non-surgical Periodontal Treatment (Nspt) On R...mentioning

confidence: 99%

The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review

Inchingolo,

Avantario

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Association between periodontitis and cardiovascular health in rheumatoid arthritis patients: Prospective effect of periodontal treatment on cardiovascular risk

Cited by 1 publication

References 41 publications

The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review

The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review

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