Association between periodontitis and blood lipid levels in a Korean population

Lee, Seyoung; Im, Ae-Jung; Burm, Eunae; Ha, Mina

doi:10.1902/jop.2017.170111

Cited by 31 publications

(28 citation statements)

References 30 publications

(31 reference statements)

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“…32 The systemic inflammation produced by chronic periodontitis is also the basis for the association between periodontitis and an increase in plasma levels of LDL-cholesterol and triglycerides as well as reduction in levels of HDL-cholesterol. 33 The significant association with triglycerides and HDL-c was confirmed, but the association with LDL-c was not observed in the present study.…”

Section: Discussioncontrasting

confidence: 56%

Relationship between periodontitis and subclinical risk indicators for chronic non-communicable diseases

et al. 2020

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Section: Discussioncontrasting

confidence: 56%

Relationship between periodontitis and subclinical risk indicators for chronic non-communicable diseases

et al. 2020

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“…These findings were consistent with the results of previous studies. (42)(43)(44) For instance, in another similar cross-sectional study, hyperlipidaemic patients who were not taking ATV, when compared with normolipidemic individuals and the hyperlipidemic group which used a daily dose of 20 mg ATV, had significantly increased gingival bleeding index and probing depth. It was concluded that ATV as a statin has an appreciated effect on periodontal health status.…”

Section: Discussionmentioning

confidence: 99%

Does Atorvastatin Alone Ameliorate Chronic Periodontitis in Hyperlipidemic Patients? (A Cross-Sectional Study)

El-Sharkawy

Felemban

Manjunatha

2018

Egyptian Dental Journal

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The present study was conducted to assess whether atorvastatin (ATV) alone could improve periodontal parameters and reduce inflammation and bone resorption in generalized chronic periodontitis (gCP) patients with hyperlipidemia. One hundred and two subjects were classified into three groups: Group I included 34 gCP patients with hyperlipidemia and maintained on a daily dose of 20 mg atorvastatin at least for 6 months. Group II comprised 34 gCP patients with hyperlipidemia and not taking any hypolipidemic drugs. Group III consisted of 34 normolipidemic individuals with gCP. The periodontal parameters including plaque index (PI), bleeding on probing (BOP), gingival index (GI), probing depth (PD) and clinical attachment loss (CAL) were recorded and compared. Unstimulated whole saliva and blood samples were harvested from all subjects. Salivary levels of interleukin-1beta (IL-1β) and receptor activator of nuclear kappa B ligand (RANKL) were evaluated by enzyme-linked immunosorbent assay (ELISA) technique. The blood samples were used to assess the lipid profile for all patients including total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoproteincholesterol (HDL-C). The results demonstrated significantly greater decrease of periodontal parameters and salivary IL-1β and RANKL levels in group I compared to other groups. BOP, PD and CAL were positively correlated with the levels of salivary IL-1β, TC, TG and LDL-C whereas HDL-C measurements were negatively associated with BOP, PD and CAL. In conclusion, ATV could be a viable therapeutic modality in gCP management, due to its anti-inflammatory and antiosteopathic effects. Salivary IL-1β and RANKL could serve as reliable biomarkers in periodontal disease.

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“…Significant association was found between periodontitis and low HDL and high LDL cholesterol levels in women. [29]…”

Section: Evidence Based Overview Linking Periodontal Infection and Hymentioning

confidence: 99%

Critical appraisal of bidirectional relationship between periodontitis and hyperlipidemia

Abraham¹,

Premnath²,

Arunima³

et al. 2019

J Int Soc Prevent Communit Dent

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Periodontal disease and hyperlipidemia are both multifactorial disease with a high prevalence Worldwide. Cross-sectional and longitudinal prospective clinical studies show some evidence for a bidirectional relationship. Periodontitis and hyperlipidemia share some common risk factors and there exist a mechanistic link between both. Studies have found a positive response to periodontal therapy among hyperlipidemic patients, and statin use by hyperlipidemic patients has shown to influence the periodontal health. However, in spite of the rising prevalence of both diseases, many people remain unaware of their association with each other. Hence, this article summarizes the cyclic relationship between periodontal disease and hyperlipidemia.

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Association between periodontitis and blood lipid levels in a Korean population

Abstract: There was a significant association between periodontitis and low HDL and high LDL cholesterol levels in women.

Cited by 31 publications

References 30 publications

Relationship between periodontitis and subclinical risk indicators for chronic non-communicable diseases

Relationship between periodontitis and subclinical risk indicators for chronic non-communicable diseases

Does Atorvastatin Alone Ameliorate Chronic Periodontitis in Hyperlipidemic Patients? (A Cross-Sectional Study)

Critical appraisal of bidirectional relationship between periodontitis and hyperlipidemia

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