Association Between Periodontal Disease and Kidney Function Decline in African Americans: The Jackson Heart Study

Grubbs, Vanessa; Vittinghoff, Eric; Beck, James D.; Kshirsagar, Abhijit V.; Wang, Wei; Griswold, Michael; Powe, Neil R.; Correa, Adolfo; Young, Bessie A.

doi:10.1902/jop.2015.150195

Cited by 36 publications

(54 citation statements)

References 21 publications

(37 reference statements)

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“…Most of the included studies demonstrated an association between CKD and periodontitis, with ORs ranging from 1.39 (1.03–1.89) (Han et al., ) to 4.0 (2.7–5.9) (Sharma et al., ). When considering the type of study, all the cohort studies found an association between CKD and periodontitis (Grubbs et al., ), (Grubbs et al., ) (Iwasaki et al., ), whereas, some cross‐sectional (Messier et al., ) and case–control (Brotto et al., ) studies failed to find it. Interestingly, higher ORs were estimated when severe forms of periodontitis were considered (OR = 2.14; CI: 1.19–3.85) (Kshirsagar et al., ).…”

Section: Resultsmentioning

confidence: 99%

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

et al. 2018

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A systematic review and meta-analysis were conducted to evaluate the association between periodontitis (PD) and chronic kidney disease (CKD) and to explore the potential influence of periodontal treatment in patients with CKD. Databases (PubMed, Web of Science, Science direct, Cochrane Database) were screened for relevant articles, focusing on the periodontal status of patients with CKD, published until December 2017. Five hundred and fifty-three articles were identified, and 37 fulfilled the inclusion criteria and were considered in this systematic review. Seventeen articles were included in the meta-analysis and 7 in the review focusing on the impact of periodontal treatment. Most of the identified studies indicated an increased incidence of PD in patients with CKD. Meta-analysis showed an association between CKD and PD, and strength of this association was increased when severe PD was considered (OR = 2.39 (1.70-3.36)). The association could be observed even after adjustment for major CKD risk factors or use of precise diagnosis criteria (OR = 2.26 for severe PD (1.69-3.01)). Analysis of cohort studies indicated an incident rate ratio (IRR) of 1.73. Periodontitis is associated with CKD after multivariable adjustment. Further studies are necessary to determine whether prevention or treatment of PD can reduce the incidence and/or severity of CKD.

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Section: Resultsmentioning

confidence: 99%

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

et al. 2018

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“…In the present study, we examined several clinical parameters, including the periodontal condition, and also performed analysis after classifying the patients into groups with or without DM. Recently, Grubbs reported a positive association between periodontal disease (classified as severe vs. non‐severe) and kidney dysfunction with or without DM in African American subjects (Grubbs et al, 2015). Prior investigation of Pima Indian adults with DM and an eGFR >60 ml min −1 1.73 m −2 revealed that severe periodontal disease, diagnosed from the number of missing teeth and % alveolar bone loss on panoramic radiographs, was associated with a 3.5‐fold increase in the risk of kidney failure (Shultis et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…There is growing clinical evidence to suggest a direct or indirect association between periodontitis and kidney dysfunction (Macisaac et al, 2014; Grubbs et al, 2015). Furthermore, there is a positive correlation between periodontal disease and obesity, hypertension, hyperlipidemia, or hyperglycemia (Zhou, Zhang, Liu, Zhang, & Li, 2015), although the molecular mechanisms of these relationships are unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Because alteration of endothelial function could lead to reduction of renal blood flow, periodontal infection might consequently worsen kidney function (Tonetti et al, 2007). A recent cohort study showed that severe periodontitis is associated with kidney dysfunction in African Americans (Grubbs et al, 2015). Other clinical studies have also demonstrated a close association between CKD and periodontal disease (Ioannidou & Swede, 2011; Iwasaki et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi

Oishi

Inagaki

et al. 2016

Clinical & Exp Dental Res

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Recent studies have demonstrated that chronic kidney disease (CKD) may be associated with the progression of periodontal disease. Diabetes mellitus (DM) is a major risk factor for CKD. The objective of this study was to clarify the relationship between periodontal condition and kidney dysfunction in patients who had kidney failure with or without DM. One hundred sixty‐four patients with kidney dysfunction were enrolled (male: N = 105; female: N = 59), and the relationship between periodontal condition and kidney dysfunction was analyzed in a cross‐sectional study. The subjects were divided into three groups: (a) patients with DM, (b) dialysis patients with nephropathy due to various kidney diseases, and (c) dialysis patient with nephropathy due to DM (diabetic nephropathy). Then, the effect of DM on the periodontal condition was analyzed. The patients were also stratified by CKD stage (into G1–G5) using the estimated glomerular filtration rate (eGFR), and the G5 group was divided in patients with or without DM. Correlations between eGFR and parameters of periodontal condition were calculated in patients from G1 to G4. The number of missing teeth was significantly higher in dialysis patients with diabetic nephropathy than in patients with DM, whereas alveolar bone loss did not show a significant difference among the three groups. In addition, the G5 patients with DM had a significantly higher number of missing teeth than the other CKD groups, whereas alveolar bone loss did not show a significant difference. In G5 patients with DM, Community Periodontal Index and Oral Hygiene Index scores were significantly higher than in G1‐4 patients with DM. There was a significant negative correlation between eGFR and the number of missing teeth. Patients with diabetic nephropathy have a higher rate of periodontal problems such as missing teeth in Japanese adults.

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“…Systemic illnesses such as respiratory infections, poor glycemic control [6], kidney disease [7], and increased cardiovascular risk [4] have been reported to be associated with the periodontal status.…”

Section: Introductionmentioning

confidence: 99%

Inequalities in Oral Health among Older Brazilians: A Cross-Sectional Analysis of a National Survey

Prado

Garbín²,

Moimaz³

et al. 2018

Pesqui. bras. odontopediatria clín. integr.

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Objective: To investigate the association of tooth loss and periodontal disease with socioeconomic and demographic factors, the need for and use of health services, and the effect of oral health on the daily lives of older Brazilians. Material and Methods: We abstracted data from a nation-wide, representative, cross-sectional survey of 7619 Brazilians aged between 65 to 74 years. Poisson regression models were created to investigate associations between oral diseases and income, education level, gender, ethnicity, region of residence, and use of dental services; statistical significance was set at 5%. Results: The mean age of the 7619 subjects studied was 69 years (95% Confidence Interval, 68.9-69.1); 61.9% were women. Regarding ethnicity, 46.95% were White, 38.90% were Brown, 11.54% were Black and 2.53% belonged to other ethnic groups. Bleeding on probing or dental calculus was present in 26.67% of subjects, whereas LOA was present in 87.27%. The loss of at least one tooth was observed in 48.90% of subjects, while 47.03% were completely edentulous. Low educational status increased the prevalence ratio (PR) of all diseases (loss of attachment, PR=5.54; bleeding on probing, PR=3.93; tooth loss, PR=2.24; edentulousness, PR=3.34). The prevalence of tooth loss was 2.58 times higher in subjects who reported a monthly income of less than 301 USD. The effect on daily life was occasionally a protective factor and occasionally increased the likelihoods of diseases. Conclusion: These findings substantiate the association of socioeconomic conditions, demographic features, and use of dental services with bleeding on probing, presence of dental calculus, loss of periodontal attachment, tooth loss, and edentulousness among older Brazilian subjects.

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Association Between Periodontal Disease and Kidney Function Decline in African Americans: The Jackson Heart Study

Cited by 36 publications

References 21 publications

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Inequalities in Oral Health among Older Brazilians: A Cross-Sectional Analysis of a National Survey

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