Association between pentraxin-3 and the risk of preeclampsia

Xiong, Zhihui; Wang, Xinchen; Jiang, Si‐Cong; Jin, Meiyuan; Chen, Wenzeng

doi:10.1097/md.0000000000020744

Cited by 8 publications

(14 citation statements)

References 22 publications

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“…Even though CRP and PTX3 are indeed structurally and functionally related, their production is additionally triggered by different inflammatory stimuli, which probably reflects potential of also diverging biological functions (1,(11)(12)(13). It has been demonstrated that the expression of PTX3 in the peripheral blood is closely related to preeclampsia (19), but no such pregnancy complications has yet been firmly established for CRP (32,(40)(41)(42).…”

Section: Discussionmentioning

confidence: 99%

“…Deficiency in PTX3 causes reduced fertility in mice and reduced litter size ( 14 – 17 ), aligning with data highlighting the importance of PTX3 for implantation ( 18 ). However, increased levels of PTX3 have also been associated with preeclampsia ( 19 , 20 ). It is believed that there is an exaggerated inflammatory response and endothelial dysfunction in preeclamptic pregnancies, resulting in an increased release of inflammatory mediators such as PTX3 ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

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Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

et al. 2021

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Although several biomarkers are available to monitor the acute phase response, the short pentraxin C-reactive protein (CRP) is dominating in clinical practice. The long pentraxin 3 (PTX3) is structurally and functionally related to CRP, but not liver-derived. In addition, increased levels of PTX3 have been linked to preeclampsia. Reference intervals are usually based on healthy blood donors. Several physiological and immunological alterations occur during normal pregnancy with subsequent potential effects on blood analytes. Hence, this study aims to determine pregnancy-specific reference intervals for CRP and PTX3. Longitudinal clinical data and blood plasma samples from the 1st, 2nd and 3rd trimester of 100 healthy, non-medicating, females aged 18–40 at the time-point of conception were available to us. High‐sensitivity CRP measurements were performed by turbidimetry and enzyme-linked immunosorbent assay (ELISA) was used to quantify PTX3. CRP and PTX3 levels followed each other during the first two trimesters and both increased during the third trimester. CRP showed a median of 4.12 mg/L in the third trimester, and were significantly higher compared to the first (median 2.39 mg/L, p<0.0001) and the second (median 2.44 mg/L, p=0.0006) trimesters. In the third trimester PTX3 levels reached a median of 7.70 µg/L, and were significantly higher compared to the first (median 3.33 µg/L, p<0.0001) and the second (median 3.70 µg/L, p<0.0001) trimesters. Plasma albumin was inversely correlated with CRP (rho=-0.27, p<0.0001), but not with PTX3. In conclusion, it is important to consider pregnancy-specific reference values as elevations of CRP and PTX3 during the later phase may occur in absence of infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

et al. 2021

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“…The involvement of these proteins in PE has been previously described. The decrease in RGS2 expression contributes to PE through its inhibitory function on arterial pressure regulation [ 89 ], and PTX3 is involved in the regulation of inflammation and is upregulated in women with PE [ 86 ]. Variants in MTHFR can induce a decrease in the enzymatic activity that increases folate levels, which contributes to PE [ 87 ].…”

Section: Mirnasmentioning

confidence: 99%

Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Parada-Niño

Castillo-León

Morel

2022

Journal of Pregnancy

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Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies.

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“…Pentraxin 3 (PTX3), a member of the c-reactive protein family, is a long pentraxin protein and a pro-inflammatory marker ( 14 ). Under inflammatory conditions, PTX3 is secreted by vascular endothelial cells and monocytes ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

IL‑1β‑induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL‑1β antagonists

Wang

Zhang

2022

Mol Med Rep

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Pentraxin 3 (PTX3), a member of the c-reactive protein family, is a long pentraxin protein and a pro-inflammatory marker. However, the role of PTX3 in preeclampsia (Pe) remains to be elucidated. Thus, the present study aimed to investigate the biological role and mechanisms underlying PTX3 in Pe. in the present study, PTX3 was overexpressed in trophoblasts and the subsequent changes in cell proliferation, cycle distribution and invasion were observed using cell Counting Kit-8, flow cytometry and Transwell assays, respectively. Moreover, the expression levels of MMP2 and MMP9, proteins associated with the development of Pe, were detected using reverse transcription-quantitative Pcr and western blot analysis. Following treatment with interleukin (il)-1β, the expression levels of PTX3 were measured. Furthermore, subsequent changes in cell proliferation, cycle distribution and invasion were investigated following overexpression of PTX3 and treatment with il-1 receptor antagonist (il-1ra). overexpression of PTX3 inhibited the proliferation, cycle and invasion of HTr-8/SV neo and JeG3 cells. Moreover, treatment with il-1β increased the expression of PTX3 in HTr-8/SV neo and JeG3 cells, which was suppressed following treatment with the il-1β antagonist. Following PTX3 overexpression and treatment with il-1ra, the inhibitory effects of PTX3 overexpression alone on the invasion of HTr-8/SV neo and JeG3 cells were attenuated. in conclusion, these results indicated that il-1β could induce PTX3 upregulation, which led to the inhibition of the proliferation, invasion and cell cycle of trophoblasts, thereby promoting the progression of Pe.

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Association between pentraxin-3 and the risk of preeclampsia

Cited by 8 publications

References 22 publications

Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

Plasma C-Reactive Protein and Pentraxin-3 Reference Intervals During Normal Pregnancy

Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

IL‑1β‑induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL‑1β antagonists

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