Association between pelvic nodal radiotherapy and patient-reported functional outcomes through 5 years among men undergoing external-beam radiotherapy for prostate cancer: An assessment of the comparative effectiveness analysis of surgery and radiation (CEASAR) cohort

A Systematic Review of Population-Based Studies of Chronic Bowel Symptoms in Cancer Survivors following Pelvic Radiotherapy

“…Hand searches identified two additional eligible citations. Therefore, 45 papers from 19 datasets were included [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. Characteristics of individual papers, and associated populations, are presented in Supplementary Tables S2 and S3 , respectively.…”

“…Papers reported on datasets from nine countries: USA ( n = 5 datasets; n = 20 papers) [ 16 , 20 , 21 , 28 , 29 , 30 , 31 , 32 , 33 , 35 , 40 , 43 , 48 , 49 , 50 , 52 , 53 , 56 , 57 , 59 ], Australia ( n = 4 datasets of which n = 1 reported with New Zealand; n = 5 papers) [ 17 , 38 , 44 , 51 , 54 ]; the Netherlands ( n = 2 datasets; n = 2 papers) [ 39 , 58 ], Sweden ( n = 2 datasets; n = 6 papers) [ 15 , 18 , 19 , 24 , 25 , 55 ], the United Kingdom ( n = 2 datasets; n = 6 papers) [ 22 , 37 , 42 , 45 , 46 , 47 ], Denmark ( n = 1 dataset; n = 1 paper) [ 41 ], Ireland and Northern Ireland ( n = 1 dataset reported together; n = 2 papers) [ 23 , 27 ], Finland ( n = 1 dataset; n = 1 paper) [ 36 ], and Norway ( n = 1 dataset; n = 2 papers) [ 26 , 34 ]. A total...…”

“…In total, 22 papers ( n = 12 datasets) reported cross-sectional analyses [ 15 , 18 , 19 , 22 , 23 , 24 , 25 , 26 , 27 , 29 , 30 , 34 , 36 , 39 , 42 , 44 , 45 , 46 , 47 , 51 , 55 , 58 ] and 23 papers ( n = 9 datasets; all prostate) reported longitudinal analyses [ 16 , 17 , 20 , 21 , 28 , 31 , 32 , 33 , 35 , 37 , 38 , 40 , 41 , 43 , 48 , 49 , 50 , 52 , 53 , 54 , 56 , 57 , 59 ]. Seven different previously validated outcome measurement tools were used ( Supplementary Table S4 ): Expanded Prostate Cancer Index Composite (EPIC)-26 ( n = 23 papers) [ 16 , 17 , 21 , 22 , 26 , ...…”

“…The most frequently reported bowel outcome was a bowel function score ( n = 26 papers) [ 16 , 20 , 21 , 22 , 23 , 26 , 28 , 31 , 32 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 51 , 54 , 56 , 57 , 58 , 59 ] followed by bowel function ‘bother’ ( n = 19) [ 15 , 16 , 17 , 19 , 21 , 26 , 27 , 28 , 30 , 31 , 33 , 34 , 35 , 48 , 49 , 51 , 52 , 53 , 54 ], urgency ( n = 16) [ 15 , 16 , 18 , 21 , 22 , 25 , 26 , 28 ,…”

“…All ten papers [ 21 , 28 , 29 , 31 , 33 , 35 , 48 , 53 , 54 , 59 ] which compared bowel symptoms post-radiotherapy to pre-radiotherapy reported a higher prevalence or greater severity post-treatment than beforehand ( Table 2 ).…”